Tmem11 transmembrane protein 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem11provided by MGI
Official Full Name: transmembrane protein 11provided by MGI
Primary source: MGI:MGI:2144726
See related: Ensembl:ENSMUSG00000043284 AllianceGenome:MGI:2144726
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730466P16Rik
Summary: Predicted to be involved in inner mitochondrial membrane organization. Located in mitochondrion. Is expressed in cap mesenchyme and renal interstitium. Orthologous to human TMEM11 (transmembrane protein 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 40.7), adrenal adult (RPKM 32.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.9 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (60755278..60769864, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (60864452..60879038, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m[7]G methylation of ATF5 mRNA.
Title: TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m(7)G methylation of ATF5 mRNA.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in inner mitochondrial membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 11, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168507.1 → NP_001161979.1 transmembrane protein 11, mitochondrial isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AL596215, CX211768

Consensus CDS

CCDS48815.1

UniProtKB/TrEMBL

E9Q933

Related

ENSMUSP00000128654.2, ENSMUST00000168218.8

Conserved Domains (1) summary

pfam14972
Location:12 → 174

Mito_morph_reg; Mitochondrial morphogenesis regulator
NM_173453.3 → NP_775655.1 transmembrane protein 11, mitochondrial isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AI835409, AK077600, AL596215

Consensus CDS

CCDS24801.1

UniProtKB/Swiss-Prot

Q5NCT6, Q8BK08

Related

ENSMUSP00000059494.6, ENSMUST00000062677.12

Conserved Domains (1) summary

pfam14972
Location:26 → 188

Mito_morph_reg; Mitochondrial morphogenesis regulator