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    Osbp2 oxysterol binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 74309, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Osbp2provided by MGI
    Official Full Name
    oxysterol binding protein 2provided by MGI
    Primary source
    MGI:MGI:1921559
    See related
    Ensembl:ENSMUSG00000020435 AllianceGenome:MGI:1921559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm244; ORP-4; OSBPL1; 1700095P05Rik; C630001G20Rik
    Summary
    The protein encoded by this gene belongs to the oxysterol-binding protein-related family of proteins, which are defined by a C-terminal sterol domain with a highly conserved EQVSHHPP motif. Oxysterols are oxygenated derivatives of cholesterol that are involved in mechanisms that include apoptosis, cholesterol homeostasis, lipid trafficking and cell differentiation. This protein is selectively expressed at high levels in the brain and testis. Within the testis, the mRNA is localized to postmeiotic germ cells, including spermatids and spermatozoa, but is not detectable in somatic cells. Mice homozygous mutant for a targeted deletion in this gene do not exhibit overt developmental phenotypes but are male sterile. Females display normal fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in testis adult (RPKM 125.0), cortex adult (RPKM 12.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osbp2 in Genome Data Viewer
    Location:
    11 A1; 11 2.6 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3653731..3814000, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3703731..3863999, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6944 Neighboring gene STARR-seq mESC enhancer starr_28362 Neighboring gene microrchidia 2A Neighboring gene STARR-seq mESC enhancer starr_28363 Neighboring gene nucleolar and spindle associated protein 1 pseudogene Neighboring gene predicted gene, 51881 Neighboring gene predicted gene, 51882 Neighboring gene predicted gene, 24013 Neighboring gene STARR-seq mESC enhancer starr_28364 Neighboring gene predicted gene, 51880 Neighboring gene STARR-seq mESC enhancer starr_28365 Neighboring gene STARR-positive B cell enhancer ABC_E8382 Neighboring gene RIKEN cDNA 4921536K21 gene Neighboring gene nucleolar protein 8 pseudogene Neighboring gene dual specificity phosphatase 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family. Udagawa O, et al. Genes Cells, 2014 Jan. PMID 24245814
    2. Coiled-coil domain containing 159 is required for spermatid head and tail assembly in mice†. Ge T, et al. Biol Reprod, 2024 May 9. PMID 38236177
    3. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ORP4 is essential for the postmeiotic differentiation of germ cells
      Title: Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302630.2 → NP_001289559.1  oxysterol-binding protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001289559.1

      Status: VALIDATED

      Source sequence(s)
      BC058356, BC058602, CV784397
      Consensus CDS
      CCDS78912.1
      UniProtKB/TrEMBL
      Q5QNQ4, Q8K0C7
      Related
      ENSMUSP00000100015.4, ENSMUST00000102950.10
      Conserved Domains (1) summary
      pfam01237
      Location:66 → 435
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001302631.2 → NP_001289560.1  oxysterol-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK044598, AL731853, BC058356, CV784397
      UniProtKB/TrEMBL
      Q5QNQ4
      Related
      ENSMUSP00000099156.4, ENSMUST00000101632.4
      Conserved Domains (1) summary
      pfam01237
      Location:108 → 478
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_001363163.1 → NP_001350092.1  oxysterol-binding protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL691413, AL731853
      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:522 → 891
      Oxysterol_BP; Oxysterol-binding protein

    4. NM_001363164.1 → NP_001350093.1  oxysterol-binding protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL691413, AL731853
      UniProtKB/TrEMBL
      Q5QNQ4, Q6PE09
      Conserved Domains (1) summary
      pfam01237
      Location:155 → 530
      Oxysterol_BP; Oxysterol-binding protein

    5. NM_152818.3 → NP_690031.2  oxysterol-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_690031.2

      Status: VALIDATED

      Source sequence(s)
      AK049816, BC058356
      Consensus CDS
      CCDS24367.1
      UniProtKB/Swiss-Prot
      Q5QNQ6, Q8CF21
      Related
      ENSMUSP00000068652.8, ENSMUST00000070552.14
      Conserved Domains (3) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam00169
      Location:182 → 271
      PH; PH domain
      pfam01237
      Location:519 → 888
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3653731..3814000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514851.5 → XP_006514914.1  oxysterol-binding protein 2 isoform X11

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:519 → 895
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_011243765.3 → XP_011242067.1  oxysterol-binding protein 2 isoform X9

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:519 → 900
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_006514849.5 → XP_006514912.1  oxysterol-binding protein 2 isoform X10

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:522 → 898
      Oxysterol_BP; Oxysterol-binding protein

    4. XM_011243763.3 → XP_011242065.1  oxysterol-binding protein 2 isoform X6

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:522 → 903
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_036157045.1 → XP_036012938.1  oxysterol-binding protein 2 isoform X8

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 901
      Oxysterol_BP; Oxysterol-binding protein

    6. XM_036157044.1 → XP_036012937.1  oxysterol-binding protein 2 isoform X7

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 902
      Oxysterol_BP; Oxysterol-binding protein

    7. XM_036157041.1 → XP_036012934.1  oxysterol-binding protein 2 isoform X3

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 907
      Oxysterol_BP; Oxysterol-binding protein

    8. XM_036157043.1 → XP_036012936.1  oxysterol-binding protein 2 isoform X5

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:529 → 904
      Oxysterol_BP; Oxysterol-binding protein

    9. XM_036157042.1 → XP_036012935.1  oxysterol-binding protein 2 isoform X4

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:529 → 905
      Oxysterol_BP; Oxysterol-binding protein

    10. XM_036157040.1 → XP_036012933.1  oxysterol-binding protein 2 isoform X2

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:529 → 909
      Oxysterol_BP; Oxysterol-binding protein

    11. XM_036157039.1 → XP_036012932.1  oxysterol-binding protein 2 isoform X1

      Conserved Domains (2) summary
      cd13284
      Location:182 → 278
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam01237
      Location:529 → 910
      Oxysterol_BP; Oxysterol-binding protein

    12. XM_030246382.1 → XP_030102242.1  oxysterol-binding protein 2 isoform X12

      Conserved Domains (2) summary
      pfam01237
      Location:323 → 704
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:13 → 79
      PH-like; Pleckstrin homology-like domain

    13. XM_011243769.3 → XP_011242071.1  oxysterol-binding protein 2 isoform X24

      See identical proteins and their annotated locations for XP_011242071.1

      UniProtKB/TrEMBL
      Q5QNQ4
      Conserved Domains (1) summary
      pfam01237
      Location:158 → 539
      Oxysterol_BP; Oxysterol-binding protein

    14. XM_030246389.2 → XP_030102249.1  oxysterol-binding protein 2 isoform X25

      UniProtKB/TrEMBL
      Q5QNQ4
      Conserved Domains (1) summary
      pfam01237
      Location:155 → 536
      Oxysterol_BP; Oxysterol-binding protein

    15. XM_030246391.1 → XP_030102251.1  oxysterol-binding protein 2 isoform X27

      UniProtKB/TrEMBL
      Q5QNQ4, Q6PE09
      Conserved Domains (1) summary
      pfam01237
      Location:155 → 530
      Oxysterol_BP; Oxysterol-binding protein

    16. XM_011243771.2 → XP_011242073.1  oxysterol-binding protein 2 isoform X24

      See identical proteins and their annotated locations for XP_011242073.1

      UniProtKB/TrEMBL
      Q5QNQ4
      Conserved Domains (1) summary
      pfam01237
      Location:158 → 539
      Oxysterol_BP; Oxysterol-binding protein

    17. XM_030246390.1 → XP_030102250.1  oxysterol-binding protein 2 isoform X26

      UniProtKB/TrEMBL
      Q5QNQ4
      Conserved Domains (1) summary
      pfam01237
      Location:155 → 531
      Oxysterol_BP; Oxysterol-binding protein

    18. XM_011243770.3 → XP_011242072.1  oxysterol-binding protein 2 isoform X24

      See identical proteins and their annotated locations for XP_011242072.1

      UniProtKB/TrEMBL
      Q5QNQ4
      Conserved Domains (1) summary
      pfam01237
      Location:158 → 539
      Oxysterol_BP; Oxysterol-binding protein

    19. XM_030246388.1 → XP_030102248.1  oxysterol-binding protein 2 isoform X23

      Conserved Domains (1) summary
      pfam01237
      Location:263 → 638
      Oxysterol_BP; Oxysterol-binding protein

    20. XM_030246387.1 → XP_030102247.1  oxysterol-binding protein 2 isoform X22

      Conserved Domains (1) summary
      pfam01237
      Location:263 → 639
      Oxysterol_BP; Oxysterol-binding protein

    21. XM_011243768.4 → XP_011242070.1  oxysterol-binding protein 2 isoform X15

      Conserved Domains (1) summary
      pfam01237
      Location:266 → 647
      Oxysterol_BP; Oxysterol-binding protein

    22. XM_011243766.4 → XP_011242068.1  oxysterol-binding protein 2 isoform X13

      Conserved Domains (1) summary
      pfam01237
      Location:270 → 651
      Oxysterol_BP; Oxysterol-binding protein

    23. XM_017314809.1 → XP_017170298.1  oxysterol-binding protein 2 isoform X21

      Conserved Domains (1) summary
      pfam01237
      Location:255 → 636
      Oxysterol_BP; Oxysterol-binding protein

    24. XM_030246384.1 → XP_030102244.1  oxysterol-binding protein 2 isoform X17

      Conserved Domains (1) summary
      pfam01237
      Location:264 → 644
      Oxysterol_BP; Oxysterol-binding protein

    25. XM_030246385.1 → XP_030102245.1  oxysterol-binding protein 2 isoform X18

      Conserved Domains (1) summary
      pfam01237
      Location:267 → 642
      Oxysterol_BP; Oxysterol-binding protein

    26. XM_030246386.1 → XP_030102246.1  oxysterol-binding protein 2 isoform X20

      Conserved Domains (1) summary
      pfam01237
      Location:264 → 639
      Oxysterol_BP; Oxysterol-binding protein

    27. XM_006514860.4 → XP_006514923.1  oxysterol-binding protein 2 isoform X19

      Conserved Domains (1) summary
      pfam01237
      Location:264 → 640
      Oxysterol_BP; Oxysterol-binding protein

    28. XM_030246383.1 → XP_030102243.1  oxysterol-binding protein 2 isoform X16

      Conserved Domains (1) summary
      pfam01237
      Location:264 → 645
      Oxysterol_BP; Oxysterol-binding protein

    29. XM_011243767.3 → XP_011242069.1  oxysterol-binding protein 2 isoform X14

      Conserved Domains (1) summary
      pfam01237
      Location:267 → 648
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5QNQ6.1 GenPept UniProtKB/Swiss-Prot:Q5QNQ6

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