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    HYAL4 hyaluronidase 4 [ Homo sapiens (human) ]

    Gene ID: 23553, updated on 2-Nov-2024

    Summary

    Official Symbol
    HYAL4provided by HGNC
    Official Full Name
    hyaluronidase 4provided by HGNC
    Primary source
    HGNC:HGNC:5323
    See related
    Ensembl:ENSG00000106302 MIM:604510; AllianceGenome:HGNC:5323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSHY; HYAL-4
    Summary
    This gene encodes a protein which is similar in structure to hyaluronidases but lacks hyaluronidase activity. The encoded protein acts as a chondroitin-sulfate-specific endo-beta-N-acetylgalactosaminidase; that is, it exhibits hydrolytic activity toward chondroitin sulfate chains and degrades them into oligosaccharides. Proteoglycans are formed by the covalent linkage of chondroitin sulfate chains to protein. Proteoglycans are ubiquitous components of the extracellular matrix of connective tissues and are also found at the surface of many cell types where they participate in a variety of cellular processes such as cell proliferation, differentiation, migration, cell-cell recognition, extracellular matrix deposition, and tissue morphogenesis. The expression of this gene is highest in testes and placenta. [provided by RefSeq, Apr 2019]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HYAL4 in Genome Data Viewer
    Location:
    7q31.32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (123763708..123877481)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (125161887..125194214)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (123485223..123517535)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:123332146-123332646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:123332647-123333147 Neighboring gene WASP like actin nucleation promoting factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18587 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:123388787-123389441 Neighboring gene WASL divergent transcript Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:123438019-123438540 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:123438541-123439062 Neighboring gene RNA, U6 small nuclear 11, pseudogene Neighboring gene hyaluronidase 6, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:123534015-123535214 Neighboring gene COX6A1 pseudogene 6 Neighboring gene sperm adhesion molecule 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:123634231-123635109 Neighboring gene uncharacterized LOC105375483

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hyalurononglucosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondroitin sulfate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycosaminoglycan catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hyaluronan catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    hyaluronidase-4
    Names
    chondroitin sulfate endo-beta-N-acetylgalactosaminidase
    chondroitin sulfate hydrolase
    hyaluronoglucosaminidase 4
    NP_036401.2
    XP_011514292.1
    XP_024302471.1
    XP_047276049.1
    XP_047276050.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012269.3NP_036401.2  hyaluronidase-4

      See identical proteins and their annotated locations for NP_036401.2

      Status: REVIEWED

      Source sequence(s)
      AC006029, AF009010, BC104788, BF085228, BG013757
      Consensus CDS
      CCDS5789.1
      UniProtKB/Swiss-Prot
      D0VXG1, Q2M3T9, Q9UL99, Q9Y6T9
      Related
      ENSP00000223026.4, ENST00000223026.9
      Conserved Domains (1) summary
      pfam01630
      Location:41369
      Glyco_hydro_56; Hyaluronidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      123763708..123877481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420093.1XP_047276049.1  hyaluronidase-4 isoform X1

      UniProtKB/Swiss-Prot
      D0VXG1, Q2M3T9, Q9UL99, Q9Y6T9
    2. XM_011515990.2XP_011514292.1  hyaluronidase-4 isoform X1

      See identical proteins and their annotated locations for XP_011514292.1

      UniProtKB/Swiss-Prot
      D0VXG1, Q2M3T9, Q9UL99, Q9Y6T9
      Conserved Domains (1) summary
      pfam01630
      Location:41369
      Glyco_hydro_56; Hyaluronidase
    3. XM_047420094.1XP_047276050.1  hyaluronidase-4 isoform X1

      UniProtKB/Swiss-Prot
      D0VXG1, Q2M3T9, Q9UL99, Q9Y6T9
      Related
      ENSP00000417186.1, ENST00000476325.5
    4. XM_024446703.1XP_024302471.1  hyaluronidase-4 isoform X2

      Conserved Domains (1) summary
      pfam01630
      Location:41339
      Glyco_hydro_56; Hyaluronidase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      125161887..125194214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)