ZDHHC14 zinc finger DHHC-type palmitoyltransferase 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZDHHC14provided by HGNC
Official Full Name: zinc finger DHHC-type palmitoyltransferase 14provided by HGNC
Primary source: HGNC:HGNC:20341
See related: Ensembl:ENSG00000175048 MIM:619295; AllianceGenome:HGNC:20341
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NEW1CP
Summary: Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in brain (RPKM 2.5), endometrium (RPKM 2.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q25.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (157381190..157678157)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (158623184..158923532)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (157802222..158099189)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
Title: The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
Results indicate that ZDHHC14 is involved in tumor progression in patients with scirrhous type gastric cancer.
Title: Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer.
Identify ZDHHC14 as a novel tumour suppressor gene that is commonly down-regulated in testicular germ cell tumours and prostate cancer.
Title: Identification of ZDHHC14 as a novel human tumour suppressor gene.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-153308 (e-PCR)
- UniSTS:177667

D6S1983 (e-PCR)
- UniSTS:33284

RH70412 (e-PCR)
- UniSTS:33031

RH69780 (e-PCR)
- UniSTS:50440

WI-14340 (e-PCR)
- UniSTS:60432

D6S415 (e-PCR), detects polymorphism
- UniSTS:65054

D6S415 (e-PCR), detects polymorphism
- UniSTS:92194

SHGC-34875 (e-PCR)
- UniSTS:56404

D6S2433 (e-PCR), detects polymorphism
- UniSTS:5990

SHGC-145220 (e-PCR)
- UniSTS:174452

D6S1007 (e-PCR)
- UniSTS:58499

SHGC-147341 (e-PCR)
- UniSTS:175753

RH36302 (e-PCR)
- UniSTS:52367

SHGC-58189 (e-PCR)
- UniSTS:29869

D6S415 (e-PCR), detects polymorphism
- UniSTS:23767

RH46611 (e-PCR)
- UniSTS:4850

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in peptidyl-L-cysteine S-palmitoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC14

Names: DHHC domain-containing cysteine-rich protein 14; DHHC-14; NEW1 domain-containing protein; probable palmitoyltransferase ZDHHC14; zinc finger DHHC domain-containing protein 14; zinc finger DHHC-type containing 14; zinc finger, DHHC domain containing 14

NP_078906.2

EC 2.3.1.225

NP_714968.1

EC 2.3.1.225

XP_016866797.1

EC 2.3.1.225

XP_016866798.1

EC 2.3.1.225

XP_016866799.1

EC 2.3.1.225

XP_047275322.1

EC 2.3.1.225

XP_047275324.1

EC 2.3.1.225

XP_054212412.1

EC 2.3.1.225

XP_054212413.1

EC 2.3.1.225

XP_054212414.1

EC 2.3.1.225

XP_054212415.1

EC 2.3.1.225

XP_054212416.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024630.3 → NP_078906.2 palmitoyltransferase ZDHHC14 isoform 1

See identical proteins and their annotated locations for NP_078906.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF542388, AL117344, AL133510

Consensus CDS

CCDS5252.1

UniProtKB/Swiss-Prot

A6NDB7, Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q8IZN3, Q9H7F1

UniProtKB/TrEMBL

A4FVA9

Related

ENSP00000352821.5, ENST00000359775.10

Conserved Domains (2) summary

PHA03247
Location:314 → 485

PHA03247; large tegument protein UL36; Provisional

pfam01529
Location:164 → 287

DHHC; DHHC palmitoyltransferase
NM_153746.2 → NP_714968.1 palmitoyltransferase ZDHHC14 isoform 2

See identical proteins and their annotated locations for NP_714968.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AF542389, AL117344

Consensus CDS

CCDS47510.1

UniProtKB/TrEMBL

A4FVA9

Related

ENSP00000410713.2, ENST00000414563.6

Conserved Domains (2) summary

PHA03247
Location:314 → 470

PHA03247; large tegument protein UL36; Provisional

pfam01529
Location:164 → 287

DHHC; DHHC palmitoyltransferase