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    PLEKHA5 pleckstrin homology domain containing A5 [ Homo sapiens (human) ]

    Gene ID: 54477, updated on 3-Nov-2024

    Summary

    Official Symbol
    PLEKHA5provided by HGNC
    Official Full Name
    pleckstrin homology domain containing A5provided by HGNC
    Primary source
    HGNC:HGNC:30036
    See related
    Ensembl:ENSG00000052126 MIM:607770; AllianceGenome:HGNC:30036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PEPP2; PEPP-2
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to act upstream of or within reproductive system development. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 6.7), ovary (RPKM 5.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PLEKHA5 in Genome Data Viewer
    Location:
    12p12.3
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (19129733..19376400)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (19006407..19253173)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (19282667..19529334)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak1590 silencer Neighboring gene ribosomal protein L7 pseudogene 6 Neighboring gene BORCS8 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 459, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:19350483-19350983 Neighboring gene uncharacterized LOC124902892 Neighboring gene RNA, 7SL, cytoplasmic 67, pseudogene Neighboring gene serine and arginine rich splicing factor 11 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6074 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:19560966-19561466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:19563503-19564395 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:19584202-19585401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6079 Neighboring gene programmed cell death 5 pseudogene 1 Neighboring gene AE binding protein 2 Neighboring gene RNA, U6 small nuclear 254, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10667, FLJ26734, FLJ31492, KIAA1686

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-5-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in reproductive system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pleckstrin homology domain-containing family A member 5
    Names
    PH domain-containing family A member 5
    phosphoinositol 3-phosphate-binding protein-2
    pleckstrin homology domain containing, family A member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143821.3NP_001137293.2  pleckstrin homology domain-containing family A member 5 isoform 2

      See identical proteins and their annotated locations for NP_001137293.2

      Status: VALIDATED

      Source sequence(s)
      AB051473, AC087314, AC091805, AC092828
      Consensus CDS
      CCDS44840.2
      UniProtKB/TrEMBL
      B4DHK5
      Related
      ENSP00000439673.1, ENST00000538714.5
      Conserved Domains (3) summary
      COG1196
      Location:617836
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    2. NM_001190860.3NP_001177789.2  pleckstrin homology domain-containing family A member 5 isoform 3

      See identical proteins and their annotated locations for NP_001177789.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, lacks several 3' coding exons and differs in the 3' UTR, compared to variant 5. This results in a shorter protein (isoform 3), compared to isoform 4.
      Source sequence(s)
      AC024902, AC092828, BC044245
      Consensus CDS
      CCDS55809.1
      UniProtKB/Swiss-Prot
      Q9HAU0
      Related
      ENSP00000439396.1, ENST00000540972.5
      Conserved Domains (1) summary
      pfam00397
      Location:1241
      WW; WW domain
    3. NM_001256470.2NP_001243399.1  pleckstrin homology domain-containing family A member 5 isoform 4

      See identical proteins and their annotated locations for NP_001243399.1

      Status: VALIDATED

      Source sequence(s)
      AB642244, AC091805, AC092828, AL834259
      Consensus CDS
      CCDS58213.1
      UniProtKB/TrEMBL
      B4DHK5
      Related
      ENSP00000404296.2, ENST00000429027.7
      Conserved Domains (3) summary
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:170266
      PH; PH domain
      pfam00397
      Location:5887
      WW; WW domain
    4. NM_001256787.2NP_001243716.1  pleckstrin homology domain-containing family A member 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      Consensus CDS
      CCDS58214.1
      UniProtKB/TrEMBL
      B4DJX4
      Related
      ENSP00000400411.2, ENST00000424268.5
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:62158
      PH; PH domain
    5. NM_001385923.1NP_001372852.1  pleckstrin homology domain-containing family A member 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG1196
      Location:610875
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    6. NM_001385924.1NP_001372853.1  pleckstrin homology domain-containing family A member 5 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG1196
      Location:616869
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    7. NM_001385925.1NP_001372854.1  pleckstrin homology domain-containing family A member 5 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG1196
      Location:610863
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    8. NM_001385926.1NP_001372855.1  pleckstrin homology domain-containing family A member 5 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG1196
      Location:616881
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    9. NM_001385927.1NP_001372856.1  pleckstrin homology domain-containing family A member 5 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG1196
      Location:601841
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    10. NM_001385928.1NP_001372857.1  pleckstrin homology domain-containing family A member 5 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (2) summary
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    11. NM_001385929.1NP_001372858.1  pleckstrin homology domain-containing family A member 5 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG1196
      Location:616881
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    12. NM_001385930.1NP_001372859.1  pleckstrin homology domain-containing family A member 5 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG1196
      Location:610875
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    13. NM_001385931.1NP_001372860.1  pleckstrin homology domain-containing family A member 5 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG1196
      Location:616869
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    14. NM_001385932.1NP_001372861.1  pleckstrin homology domain-containing family A member 5 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG4372
      Location:609759
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    15. NM_001385933.1NP_001372862.1  pleckstrin homology domain-containing family A member 5 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (2) summary
      COG1196
      Location:508773
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    16. NM_001385934.1NP_001372863.1  pleckstrin homology domain-containing family A member 5 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG4372
      Location:613804
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    17. NM_001385935.1NP_001372864.1  pleckstrin homology domain-containing family A member 5 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      Consensus CDS
      CCDS91659.1
      UniProtKB/TrEMBL
      A0A8V8TQJ8, B4DJX4
      Related
      ENSP00000515145.1, ENST00000700688.1
      Conserved Domains (2) summary
      COG1196
      Location:502755
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    18. NM_001385936.1NP_001372865.1  pleckstrin homology domain-containing family A member 5 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG4372
      Location:607798
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    19. NM_001385937.1NP_001372866.1  pleckstrin homology domain-containing family A member 5 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (2) summary
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    20. NM_001385938.1NP_001372867.1  pleckstrin homology domain-containing family A member 5 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (3) summary
      COG4372
      Location:609759
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    21. NM_001385939.1NP_001372868.1  pleckstrin homology domain-containing family A member 5 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG1196
      Location:508773
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    22. NM_001385940.1NP_001372869.1  pleckstrin homology domain-containing family A member 5 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      Consensus CDS
      CCDS91660.1
      UniProtKB/TrEMBL
      A0A8V8TQ09, B4DJX4
      Related
      ENSP00000515143.1, ENST00000700686.1
      Conserved Domains (2) summary
      COG4372
      Location:499690
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    23. NM_001385941.1NP_001372870.1  pleckstrin homology domain-containing family A member 5 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG1196
      Location:502767
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    24. NM_001385942.1NP_001372871.1  pleckstrin homology domain-containing family A member 5 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG1196
      Location:508761
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    25. NM_001385943.1NP_001372872.1  pleckstrin homology domain-containing family A member 5 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (3) summary
      COG4372
      Location:609759
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    26. NM_001385944.1NP_001372873.1  pleckstrin homology domain-containing family A member 5 isoform 27

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG1196
      Location:502755
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    27. NM_001385945.1NP_001372874.1  pleckstrin homology domain-containing family A member 5 isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DJX4
      Conserved Domains (2) summary
      COG4372
      Location:501669
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    28. NM_001385946.1NP_001372875.1  pleckstrin homology domain-containing family A member 5 isoform 29

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (3) summary
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:607807
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00397
      Location:5887
      WW; WW domain
    29. NM_001385947.1NP_001372876.1  pleckstrin homology domain-containing family A member 5 isoform 30

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG1196
      Location:502767
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    30. NM_001385948.1NP_001372877.1  pleckstrin homology domain-containing family A member 5 isoform 31

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (3) summary
      COG4372
      Location:589731
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    31. NM_001385949.1NP_001372878.1  pleckstrin homology domain-containing family A member 5 isoform 32

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    32. NM_001385950.1NP_001372879.1  pleckstrin homology domain-containing family A member 5 isoform 33

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DJX4
      Related
      ENSP00000440371.1, ENST00000536974.5
      Conserved Domains (2) summary
      COG4372
      Location:501651
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    33. NM_001385951.1NP_001372880.1  pleckstrin homology domain-containing family A member 5 isoform 34

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG4372
      Location:514691
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    34. NM_001385952.1NP_001372881.1  pleckstrin homology domain-containing family A member 5 isoform 35

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG4372
      Location:514691
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    35. NM_001385953.1NP_001372882.1  pleckstrin homology domain-containing family A member 5 isoform 36

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG4372
      Location:499690
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    36. NM_001385954.1NP_001372883.1  pleckstrin homology domain-containing family A member 5 isoform 37

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:493745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    37. NM_001385955.1NP_001372884.1  pleckstrin homology domain-containing family A member 5 isoform 38

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:527727
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    38. NM_001385956.1NP_001372885.1  pleckstrin homology domain-containing family A member 5 isoform 38

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:527727
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    39. NM_001385957.1NP_001372886.1  pleckstrin homology domain-containing family A member 5 isoform 38

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:527727
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    40. NM_001385958.1NP_001372887.1  pleckstrin homology domain-containing family A member 5 isoform 39

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG4372
      Location:501651
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    41. NM_001385959.1NP_001372888.1  pleckstrin homology domain-containing family A member 5 isoform 40

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:527727
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    42. NM_001385960.1NP_001372889.1  pleckstrin homology domain-containing family A member 5 isoform 41

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:499699
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    43. NM_001385961.1NP_001372890.1  pleckstrin homology domain-containing family A member 5 isoform 41

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:499699
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    44. NM_001385962.1NP_001372891.1  pleckstrin homology domain-containing family A member 5 isoform 43

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (1) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    45. NM_001385963.1NP_001372892.1  pleckstrin homology domain-containing family A member 5 isoform 44

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      A0JP02
      Conserved Domains (2) summary
      COG4372
      Location:466616
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:37124
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    46. NM_001385964.1NP_001372893.1  pleckstrin homology domain-containing family A member 5 isoform 45

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:499699
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    47. NM_001385965.1NP_001372894.1  pleckstrin homology domain-containing family A member 5 isoform 46

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      A0JP02
      Conserved Domains (2) summary
      TIGR02168
      Location:478678
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:56110
      PH-like; Pleckstrin homology-like domain
    48. NM_001385966.1NP_001372895.1  pleckstrin homology domain-containing family A member 5 isoform 47

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (1) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    49. NM_001385967.1NP_001372896.1  pleckstrin homology domain-containing family A member 5 isoform 48

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG4372
      Location:444594
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    50. NM_001385968.1NP_001372897.1  pleckstrin homology domain-containing family A member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      Consensus CDS
      CCDS44840.2
      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      COG1196
      Location:617836
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:5887
      WW; WW domain
    51. NM_001385969.1NP_001372898.1  pleckstrin homology domain-containing family A member 5 isoform 38

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:527727
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    52. NM_001385970.1NP_001372899.1  pleckstrin homology domain-containing family A member 5 isoform 38

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:527727
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    53. NM_001385971.1NP_001372900.1  pleckstrin homology domain-containing family A member 5 isoform 38

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:527727
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    54. NM_001385972.1NP_001372901.1  pleckstrin homology domain-containing family A member 5 isoform 38

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR02168
      Location:527727
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    55. NM_001385973.1NP_001372902.1  pleckstrin homology domain-containing family A member 5 isoform 39

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805
      UniProtKB/TrEMBL
      B4DMB9
      Conserved Domains (2) summary
      COG4372
      Location:501651
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd13248
      Location:56159
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    56. NM_019012.6NP_061885.2  pleckstrin homology domain-containing family A member 5 isoform 1

      See identical proteins and their annotated locations for NP_061885.2

      Status: VALIDATED

      Source sequence(s)
      AC091805, AC092828, AF302150
      Consensus CDS
      CCDS8682.1
      UniProtKB/Swiss-Prot
      A0JP03, B4DGS1, E9PHQ3, F5H0I0, Q6NSF8, Q86ST7, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9HAU0, Q9NVK8
      UniProtKB/TrEMBL
      B4DMB9
      Related
      ENSP00000299275.6, ENST00000299275.10
      Conserved Domains (3) summary
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:170266
      PH; PH domain
      pfam00397
      Location:5887
      WW; WW domain

    RNA

    1. NR_169816.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
    2. NR_169817.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
    3. NR_169818.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
    4. NR_169819.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
      Related
      ENST00000700689.1
    5. NR_169820.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828
    6. NR_169821.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC024902, AC087314, AC091805, AC092828

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      19129733..19376400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019495.2XP_016874984.1  pleckstrin homology domain-containing family A member 5 isoform X1

      UniProtKB/TrEMBL
      B4DHK5
    2. XM_017019496.2XP_016874985.1  pleckstrin homology domain-containing family A member 5 isoform X3

      UniProtKB/TrEMBL
      B4DHK5
    3. XM_047429027.1XP_047284983.1  pleckstrin homology domain-containing family A member 5 isoform X4

    4. XM_011520715.2XP_011519017.1  pleckstrin homology domain-containing family A member 5 isoform X2

      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:170266
      PH; PH domain
      pfam00397
      Location:5887
      WW; WW domain
    5. XM_006719091.2XP_006719154.1  pleckstrin homology domain-containing family A member 5 isoform X5

      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:170266
      PH; PH domain
      pfam00397
      Location:5887
      WW; WW domain
    6. XM_047429030.1XP_047284986.1  pleckstrin homology domain-containing family A member 5 isoform X9

    7. XM_047429028.1XP_047284984.1  pleckstrin homology domain-containing family A member 5 isoform X6

    8. XM_006719093.2XP_006719156.1  pleckstrin homology domain-containing family A member 5 isoform X8

      UniProtKB/TrEMBL
      B4DHK5
      Conserved Domains (3) summary
      cd13248
      Location:164267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:170266
      PH; PH domain
      pfam00397
      Location:5887
      WW; WW domain
    9. XM_017019500.2XP_016874989.1  pleckstrin homology domain-containing family A member 5 isoform X11

      UniProtKB/TrEMBL
      A0A8V8TRE5, A0A9L9PX43
      Related
      ENSP00000516470.1, ENST00000706615.1
    10. XM_017019501.2XP_016874990.1  pleckstrin homology domain-containing family A member 5 isoform X12

      UniProtKB/TrEMBL
      A0A8V8TRE5
      Related
      ENST00000706619.1
    11. XM_017019502.2XP_016874991.1  pleckstrin homology domain-containing family A member 5 isoform X13

      Conserved Domains (1) summary
      pfam00397
      Location:1241
      WW; WW domain
    12. XM_017019503.2XP_016874992.1  pleckstrin homology domain-containing family A member 5 isoform X14

      UniProtKB/Swiss-Prot
      Q9HAU0
      Conserved Domains (1) summary
      pfam00397
      Location:1241
      WW; WW domain
    13. XM_047429029.1XP_047284985.1  pleckstrin homology domain-containing family A member 5 isoform X7

    14. XM_017019497.2XP_016874986.1  pleckstrin homology domain-containing family A member 5 isoform X7

      UniProtKB/TrEMBL
      B4DJX4
    15. XM_047429031.1XP_047284987.1  pleckstrin homology domain-containing family A member 5 isoform X10

    RNA

    1. XR_001748773.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      19006407..19253173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372330.1XP_054228305.1  pleckstrin homology domain-containing family A member 5 isoform X1

    2. XM_054372332.1XP_054228307.1  pleckstrin homology domain-containing family A member 5 isoform X3

    3. XM_054372333.1XP_054228308.1  pleckstrin homology domain-containing family A member 5 isoform X4

    4. XM_054372331.1XP_054228306.1  pleckstrin homology domain-containing family A member 5 isoform X2

    5. XM_054372334.1XP_054228309.1  pleckstrin homology domain-containing family A member 5 isoform X5

    6. XM_054372339.1XP_054228314.1  pleckstrin homology domain-containing family A member 5 isoform X9

    7. XM_054372335.1XP_054228310.1  pleckstrin homology domain-containing family A member 5 isoform X6

    8. XM_054372338.1XP_054228313.1  pleckstrin homology domain-containing family A member 5 isoform X8

    9. XM_054372341.1XP_054228316.1  pleckstrin homology domain-containing family A member 5 isoform X11

      UniProtKB/TrEMBL
      A0A9L9PX43
    10. XM_054372342.1XP_054228317.1  pleckstrin homology domain-containing family A member 5 isoform X12

    11. XM_054372343.1XP_054228318.1  pleckstrin homology domain-containing family A member 5 isoform X13

    12. XM_054372344.1XP_054228319.1  pleckstrin homology domain-containing family A member 5 isoform X14

    13. XM_054372337.1XP_054228312.1  pleckstrin homology domain-containing family A member 5 isoform X7

    14. XM_054372336.1XP_054228311.1  pleckstrin homology domain-containing family A member 5 isoform X7

    15. XM_054372340.1XP_054228315.1  pleckstrin homology domain-containing family A member 5 isoform X10

    RNA

    1. XR_008488622.1 RNA Sequence