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    PKIB cAMP-dependent protein kinase inhibitor beta [ Homo sapiens (human) ]

    Gene ID: 5570, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PKIBprovided by HGNC
    Official Full Name
    cAMP-dependent protein kinase inhibitor betaprovided by HGNC
    Primary source
    HGNC:HGNC:9018
    See related
    Ensembl:ENSG00000135549 MIM:606914; AllianceGenome:HGNC:9018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRKACN2
    Summary
    This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in colon (RPKM 18.8), placenta (RPKM 15.5) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PKIB in Genome Data Viewer
    Location:
    6q22.31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (122471921..122726373)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (123660238..123914654)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (122793066..123047518)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:122721093-122721592 Neighboring gene heat shock transcription factor 2 Neighboring gene serine incorporator 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25021 Neighboring gene uncharacterized LOC124901391 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:122884938-122885474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:122884400-122884937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:122932197-122932842 Neighboring gene MPRA-validated peak6076 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:123017072-123018271 Neighboring gene MPRA-validated peak6077 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:123076853-123077432 Neighboring gene RNA, 7SL, cytoplasmic 564, pseudogene Neighboring gene fatty acid binding protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt.
      Title: Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt.
    2. results indicate that PKIB promotes cell proliferation and tumorigenesis by activating the PI3K/Akt pathway in non-small cell lung cancer (NSCLC), implying that this is an important underlying mechanism that affects the progression of NSCLC
      Title: PKIB promotes cell proliferation and the invasion-metastasis cascade through the PI3K/Akt pathway in NSCLC cells.
    3. mutation of the pseudosubstrate domain abolished the inhibitory activity of PKIB on protein kinase A activity, but had no effect on the interaction with GPR39, cell protection and induction of SRE-dependent transcription
      Title: Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.
    4. PKIB overexpression was strongly correlated with pAkt expression and triple-negative breast cancer, suggesting that PKIB overexpression might contribute to the tumor behavior and development of breast cancers.
      Title: PKIB expression strongly correlated with phosphorylated Akt expression in breast cancers and also with triple-negative breast cancer subtype.
    5. Findings show that PKIB and PKA-C kinase can have critical functions of aggressive phenotype of PCs through Akt phosphorylation and that they should be a promising molecular target for PC treatment.
      Title: Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.
    6. PKIbeta may be a novel full-length gene related to human glioma and may provide a new way to gene therapy of glioma.
      Title: [Expression and characterizations of a novel full-length gene PKIbeta related to human glioma].
    7. human PKIbeta gene (clone 436F11, GenBank with accession number: AF225513) was over-expressed in normal brain tissues
      Title: Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes.
    8. Functional studies of the rat homolog
      Title: Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase.
    9. Functional studies of the mouse homolog
      Title: Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of protein kinase (cAMP-dependent, catalytic) inhibitor beta (PKIB) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23817, DKFZp781K1114

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of positive regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase inhibitor beta
    Names
    PKI-beta
    cAMP-dependent protein kinase inhibitor 2
    protein kinase (cAMP-dependent, catalytic) inhibitor beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270393.2 → NP_001257322.1  cAMP-dependent protein kinase inhibitor beta isoform 1

      See identical proteins and their annotated locations for NP_001257322.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AL512283, BG507119, BM802552, BM969901, BU753807
      Consensus CDS
      CCDS5126.1
      UniProtKB/Swiss-Prot
      B2RCK2, Q567T9, Q5T0Z7, Q9C010
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    2. NM_001270394.2 → NP_001257323.1  cAMP-dependent protein kinase inhibitor beta isoform 2

      See identical proteins and their annotated locations for NP_001257323.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (2), which is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL512283, BC036011, BG507119, BM802552, BU753807
      Consensus CDS
      CCDS59033.1
      Related
      ENSP00000480824.1, ENST00000615438.4
      Conserved Domains (1) summary
      pfam02827
      Location:16 → 84
      PKI; cAMP-dependent protein kinase inhibitor

    3. NM_001270395.2 → NP_001257324.1  cAMP-dependent protein kinase inhibitor beta isoform 2

      See identical proteins and their annotated locations for NP_001257324.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (2), which is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL512283, BC036011, BP262756, BU753807
      Consensus CDS
      CCDS59033.1
      Related
      ENSP00000258014.3, ENST00000258014.3
      Conserved Domains (1) summary
      pfam02827
      Location:16 → 84
      PKI; cAMP-dependent protein kinase inhibitor

    4. NM_032471.6 → NP_115860.1  cAMP-dependent protein kinase inhibitor beta isoform 1

      See identical proteins and their annotated locations for NP_115860.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AL512283, BC036011, BU753807
      Consensus CDS
      CCDS5126.1
      UniProtKB/Swiss-Prot
      B2RCK2, Q567T9, Q5T0Z7, Q9C010
      Related
      ENSP00000376280.1, ENST00000392490.5
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    5. NM_181794.3 → NP_861459.1  cAMP-dependent protein kinase inhibitor beta isoform 1

      See identical proteins and their annotated locations for NP_861459.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AJ420562, AL512283, BG507119, BU753807
      Consensus CDS
      CCDS5126.1
      UniProtKB/Swiss-Prot
      B2RCK2, Q567T9, Q5T0Z7, Q9C010
      Related
      ENSP00000376281.1, ENST00000392491.6
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    6. NM_181795.3 → NP_861460.1  cAMP-dependent protein kinase inhibitor beta isoform 1

      See identical proteins and their annotated locations for NP_861460.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AK315151, AL512283, BP260889, BU753807
      Consensus CDS
      CCDS5126.1
      UniProtKB/Swiss-Prot
      B2RCK2, Q567T9, Q5T0Z7, Q9C010
      Related
      ENSP00000357437.2, ENST00000368452.7
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      122471921..122726373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419002.1 → XP_047274958.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    2. XM_011535933.4 → XP_011534235.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      See identical proteins and their annotated locations for XP_011534235.1

      Conserved Domains (1) summary
      pfam02827
      Location:16 → 84
      PKI; cAMP-dependent protein kinase inhibitor

    3. XM_047419003.1 → XP_047274959.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    4. XM_047419005.1 → XP_047274961.1  cAMP-dependent protein kinase inhibitor beta isoform X2

      UniProtKB/Swiss-Prot
      B2RCK2, Q567T9, Q5T0Z7, Q9C010

    5. XM_047419006.1 → XP_047274962.1  cAMP-dependent protein kinase inhibitor beta isoform X2

      UniProtKB/Swiss-Prot
      B2RCK2, Q567T9, Q5T0Z7, Q9C010

    6. XM_011535930.4 → XP_011534232.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      See identical proteins and their annotated locations for XP_011534232.1

      Conserved Domains (1) summary
      pfam02827
      Location:16 → 84
      PKI; cAMP-dependent protein kinase inhibitor

    7. XM_011535932.4 → XP_011534234.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      See identical proteins and their annotated locations for XP_011534234.1

      Conserved Domains (1) summary
      pfam02827
      Location:16 → 84
      PKI; cAMP-dependent protein kinase inhibitor

    8. XM_047419004.1 → XP_047274960.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    9. XM_011535937.3 → XP_011534239.1  cAMP-dependent protein kinase inhibitor beta isoform X2

      See identical proteins and their annotated locations for XP_011534239.1

      UniProtKB/Swiss-Prot
      B2RCK2, Q567T9, Q5T0Z7, Q9C010
      Related
      ENSP00000346227.2, ENST00000354275.2
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      123660238..123914654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355842.1 → XP_054211817.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    2. XM_054355841.1 → XP_054211816.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    3. XM_054355844.1 → XP_054211819.1  cAMP-dependent protein kinase inhibitor beta isoform X2

      UniProtKB/Swiss-Prot
      B2RCK2, Q567T9, Q5T0Z7, Q9C010

    4. XM_054355839.1 → XP_054211814.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    5. XM_054355840.1 → XP_054211815.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    6. XM_054355843.1 → XP_054211818.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    7. XM_054355845.1 → XP_054211820.1  cAMP-dependent protein kinase inhibitor beta isoform X2

      UniProtKB/Swiss-Prot
      B2RCK2, Q567T9, Q5T0Z7, Q9C010
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C010.1 GenPept UniProtKB/Swiss-Prot:Q9C010

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