CREB1 cAMP responsive element binding protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CREB1provided by HGNC
Official Full Name: cAMP responsive element binding protein 1provided by HGNC
Primary source: HGNC:HGNC:2345
See related: Ensembl:ENSG00000118260 MIM:123810; AllianceGenome:HGNC:2345
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CREB; CREB-1
Summary: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Expression: Ubiquitous expression in lymph node (RPKM 5.0), thyroid (RPKM 4.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q33.3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (207529962..207605988)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (208003958..208080006)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (208394686..208470712)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CREB activates the MafA promoter through proximal E-boxes and a CCAAT motif in pancreatic beta-cells.
Title: CREB activates the MafA promoter through proximal E-boxes and a CCAAT motif in pancreatic β-cells.
Dual-Specificity Phosphatase 4 Promotes Malignant Features in Colorectal Cancer Through Cyclic-AMP Response Element Binding Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta Activation.
Title: Dual-Specificity Phosphatase 4 Promotes Malignant Features in Colorectal Cancer Through Cyclic-AMP Response Element Binding Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta Activation.
CREB1 promotes expression of immune checkpoint HLA-E leading to immune escape in multiple myeloma.
Title: CREB1 promotes expression of immune checkpoint HLA-E leading to immune escape in multiple myeloma.
Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
Title: Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
Aberrant CREB1 activation in prostate cancer disrupts normal prostate luminal cell differentiation.
Title: Aberrant CREB1 activation in prostate cancer disrupts normal prostate luminal cell differentiation.
Silencing of CircTRIM25/miR-138-5p/CREB1 axis promotes chondrogenesis in osteoarthritis.
Title: Silencing of CircTRIM25/miR-138-5p/CREB1 axis promotes chondrogenesis in osteoarthritis.
Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.
Title: Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.
The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1.
Title: The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1.
The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association.
Title: The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association.
[MiR-26-3p regulates proliferation, migration, invasion and apoptosis of glioma cells by targeting CREB1].
Title: [MiR-26-3p regulates proliferation, migration, invasion and apoptosis of glioma cells by targeting CREB1].

Submit: New GeneRIF Correction See all GeneRIFs (549)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Angiomatoid fibrous histiocytoma MedGen: C1266127 OMIM: 612160 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways	PubMed
Tat	tat	HIV-1 Tat induces upregulation of HDAC2 expression and downregulation of CREB and CaMKIIa expression in human neuroblastoma SK-N-MC cells	PubMed
	tat	The function and activity of CREB is required for both Tat-induced Rho signaling and nuclear targeting of ZO-1	PubMed
	tat	HIV-1 Tat increases both CREB phosphorylation and DNA binding by 7- to 10-fold within 2 hours after stimulation in hematopoietic progenitor cells	PubMed
	tat	Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors	PubMed
	tat	The CKLF-like MARVEL transmembrane domain-containing family 2 (CMTM2) blocks HIV-1 Tat-induced AP-1 and CREB activation, which leads to suppress HIV-1 provirus transcription	PubMed
	tat	HIV-1 Tat upregulates IL-10 synthesis by ERK MAPK-dependent CREB-1 transcription factor activation through Ser(133) phosphorylation	PubMed
	tat	HIV-1 Tat protein downregulates the Ser-133 phosphorylation, activation, and expression of CREB transcription factor in PC12 neuronal cells through sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases	PubMed
	tat	Extracellular HIV-1 Tat protein induces the rapid Ser-133 phosphorylation and activation of CREB transcription factor in lymphoid cells through a signal cascade involving the MAPK pathway	PubMed
Vpr	vpr	The RNA and protein levels of cAMP responsive element binding protein (CREB) decreases in Vpr-treated human neurons compared to the untreated control	PubMed
matrix	gag	HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC35219 (e-PCR)
- UniSTS:61462

RH67919 (e-PCR)
- UniSTS:28279

CREB1_1411 (e-PCR)
- UniSTS:277126

CREB1_v456 (e-PCR)
- UniSTS:277126

D2S2634 (e-PCR)
- UniSTS:947

Creb1 (e-PCR), detects polymorphism
- UniSTS:527295

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cAMP response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in cAMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to forskolin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hepatocyte growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to zinc ion	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in lung saccule development	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by competitive promoter binding	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in pituitary gland development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell size	IEA Inferred from Electronic Annotation more info
involved_in regulation of testosterone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in response to glucagon	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to purine-containing compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in secretory granule organization	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in type I pneumocyte differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ATF4-CREB1 transcription factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ATF4-CREB1 transcription factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cyclic AMP-responsive element-binding protein 1

Names: active transcription factor CREB; cAMP-response element-binding protein-1; cyclic adenosine 3',5'-monophosphate response element binding protein; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; transactivator protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023299.1 RefSeqGene

Range

5071..81097

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001320793.2 → NP_001307722.1 cyclic AMP-responsive element-binding protein 1 isoform C

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (C) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform B.

Source sequence(s)

AC009298, AK298740, DC366797

UniProtKB/TrEMBL

B7Z5C6

Conserved Domains (1) summary

pfam02173
Location:99 → 137

pKID; pKID domain
NM_001371426.1 → NP_001358355.1 cyclic AMP-responsive element-binding protein 1 isoform B

Status: REVIEWED

Source sequence(s)

AC009298, AC079767

Consensus CDS

CCDS2375.1

UniProtKB/TrEMBL

A0A024R401, Q4ZG78, Q5U0J5

Conserved Domains (2) summary

cd14690
Location:285 → 339

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:113 → 151

pKID; pKID domain
NM_001371427.1 → NP_001358356.1 cyclic AMP-responsive element-binding protein 1 isoform A

Status: REVIEWED

Source sequence(s)

AC009298, AC079767

Consensus CDS

CCDS2374.1

UniProtKB/Swiss-Prot

P16220, P21934, Q6V963, Q9UMA7

UniProtKB/TrEMBL

A0A024R437, Q4ZG78, Q53X93

Related

ENSP00000405539.1, ENST00000430624.5

Conserved Domains (2) summary

cd14690
Location:271 → 325

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:99 → 137

pKID; pKID domain
NM_001371428.1 → NP_001358357.1 cyclic AMP-responsive element-binding protein 1 isoform D

Status: REVIEWED

Source sequence(s)

AC009298, AC079767

UniProtKB/TrEMBL

C9J896

Related

ENSP00000405711.1, ENST00000448277.5

Conserved Domains (2) summary

cd14690
Location:231 → 285

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:59 → 97

pKID; pKID domain
NM_004379.5 → NP_004370.1 cyclic AMP-responsive element-binding protein 1 isoform A

See identical proteins and their annotated locations for NP_004370.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as A) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (A) has the same N- and C-termini but is shorter compared to isoform B.

Source sequence(s)

AC079767, BC095407, BU154326

Consensus CDS

CCDS2374.1

UniProtKB/Swiss-Prot

P16220, P21934, Q6V963, Q9UMA7

UniProtKB/TrEMBL

A0A024R437, Q4ZG78, Q53X93

Related

ENSP00000236995.3, ENST00000353267.8

Conserved Domains (2) summary

cd14690
Location:271 → 325

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:99 → 137

pKID; pKID domain
NM_134442.5 → NP_604391.1 cyclic AMP-responsive element-binding protein 1 isoform B

See identical proteins and their annotated locations for NP_604391.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as B) represents the longest transcript and encodes the longest isoform (B).

Source sequence(s)

AC079767, BC010636, BU154326, DC366797

Consensus CDS

CCDS2375.1

UniProtKB/TrEMBL

A0A024R401, Q4ZG78, Q5U0J5

Related

ENSP00000387699.2, ENST00000432329.6

Conserved Domains (2) summary

cd14690
Location:285 → 339

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:113 → 151

pKID; pKID domain

RNA

NR_135473.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate segment in the 3' end compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC079767, BC010636, BU154326, DC366797, HY204508
NR_163946.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC009298, AC079767
NR_163947.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC009298, AC079767

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

207529962..207605988

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011510646.4 → XP_011508948.1 cyclic AMP-responsive element-binding protein 1 isoform X2

UniProtKB/TrEMBL

Q4ZG78

Conserved Domains (1) summary

pfam02173
Location:113 → 151

pKID; pKID domain
XM_047443437.1 → XP_047299393.1 cyclic AMP-responsive element-binding protein 1 isoform X3
XM_047443436.1 → XP_047299392.1 cyclic AMP-responsive element-binding protein 1 isoform X3
XM_011510648.4 → XP_011508950.1 cyclic AMP-responsive element-binding protein 1 isoform X4

UniProtKB/TrEMBL

Q4ZG78

Conserved Domains (1) summary

pfam02173
Location:113 → 151

pKID; pKID domain
XM_017003399.3 → XP_016858888.1 cyclic AMP-responsive element-binding protein 1 isoform X6

UniProtKB/TrEMBL

Q4ZG78
XM_047443438.1 → XP_047299394.1 cyclic AMP-responsive element-binding protein 1 isoform X4
XM_047443440.1 → XP_047299396.1 cyclic AMP-responsive element-binding protein 1 isoform X7
XM_047443439.1 → XP_047299395.1 cyclic AMP-responsive element-binding protein 1 isoform X7
XM_047443441.1 → XP_047299397.1 cyclic AMP-responsive element-binding protein 1 isoform X8
XM_047443442.1 → XP_047299398.1 cyclic AMP-responsive element-binding protein 1 isoform X9

Related

ENSP00000407227.1, ENST00000445803.5
XM_047443443.1 → XP_047299399.1 cyclic AMP-responsive element-binding protein 1 isoform X10
XM_047443435.1 → XP_047299391.1 cyclic AMP-responsive element-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A024R401, Q5U0J5
XM_011510650.4 → XP_011508952.1 cyclic AMP-responsive element-binding protein 1 isoform X5

See identical proteins and their annotated locations for XP_011508952.1

UniProtKB/TrEMBL

C9J896

Conserved Domains (2) summary

cd14690
Location:245 → 299

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:73 → 111

pKID; pKID domain
XM_047443444.1 → XP_047299400.1 cyclic AMP-responsive element-binding protein 1 isoform X11
XM_017003401.3 → XP_016858890.1 cyclic AMP-responsive element-binding protein 1 isoform X12

Conserved Domains (1) summary

cd14690
Location:55 → 109

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

208003958..208080006

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054340614.1 → XP_054196589.1 cyclic AMP-responsive element-binding protein 1 isoform X2
XM_054340616.1 → XP_054196591.1 cyclic AMP-responsive element-binding protein 1 isoform X3
XM_054340615.1 → XP_054196590.1 cyclic AMP-responsive element-binding protein 1 isoform X3
XM_054340617.1 → XP_054196592.1 cyclic AMP-responsive element-binding protein 1 isoform X4
XM_054340620.1 → XP_054196595.1 cyclic AMP-responsive element-binding protein 1 isoform X6
XM_054340618.1 → XP_054196593.1 cyclic AMP-responsive element-binding protein 1 isoform X4
XM_054340622.1 → XP_054196597.1 cyclic AMP-responsive element-binding protein 1 isoform X7
XM_054340621.1 → XP_054196596.1 cyclic AMP-responsive element-binding protein 1 isoform X7
XM_054340623.1 → XP_054196598.1 cyclic AMP-responsive element-binding protein 1 isoform X8
XM_054340624.1 → XP_054196599.1 cyclic AMP-responsive element-binding protein 1 isoform X9
XM_054340625.1 → XP_054196600.1 cyclic AMP-responsive element-binding protein 1 isoform X10
XM_054340613.1 → XP_054196588.1 cyclic AMP-responsive element-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A024R401, Q5U0J5
XM_054340619.1 → XP_054196594.1 cyclic AMP-responsive element-binding protein 1 isoform X5
XM_054340626.1 → XP_054196601.1 cyclic AMP-responsive element-binding protein 1 isoform X11
XM_054340627.1 → XP_054196602.1 cyclic AMP-responsive element-binding protein 1 isoform X12