SCARB1 scavenger receptor class B member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SCARB1provided by HGNC
Official Full Name: scavenger receptor class B member 1provided by HGNC
Primary source: HGNC:HGNC:1664
See related: Ensembl:ENSG00000073060 MIM:601040; AllianceGenome:HGNC:1664
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLCQ6; HDLQTL6
Summary: The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression: Biased expression in adrenal (RPKM 333.6), placenta (RPKM 91.6) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (124776856..124863864, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (124782134..124869001, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (125261402..125348410, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PON1 has palmitoyl-protein thioesterase (PPT) activity, and can affect the presence of SR-B1 on the endothelial cell membrane.
Title: PON1 has palmitoyl-protein thioesterase (PPT) activity, and can affect the presence of SR-B1 on the endothelial cell membrane.
SR-BI regulates the synergistic mast cell response by modulating the plasma membrane-associated cholesterol pool.
Title: SR-BI regulates the synergistic mast cell response by modulating the plasma membrane-associated cholesterol pool.
Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions.
Title: Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions.
An innovative viewpoint on the existing and prospectiveness of SR-B1.
Title: An innovative viewpoint on the existing and prospectiveness of SR-B1.
Bridging the gap between clear cell renal cell carcinoma and cutaneous melanoma: the role of SCARB1 in dysregulated cholesterol metabolism.
Title: Bridging the gap between clear cell renal cell carcinoma and cutaneous melanoma: the role of SCARB1 in dysregulated cholesterol metabolism.
H19 recruited N 6 -methyladenosine (m 6 A) reader YTHDF1 to promote SCARB1 translation and facilitate angiogenesis in gastric cancer.
Title: H19 recruited N 6 -methyladenosine (m 6 A) reader YTHDF1 to promote SCARB1 translation and facilitate angiogenesis in gastric cancer.
[Association Analysis Between Methylation of SCARB1 Gene Promoter and Coronary Heart Disease].
Title: [Association Analysis Between Methylation of SCARB1 Gene Promoter and Coronary Heart Disease].
The potential role of scavenger receptor B type I (SR-BI) in SARS-CoV-2 infection.
Title: The potential role of scavenger receptor B type I (SR-BI) in SARS-CoV-2 infection.
Mechanism for the selective uptake of macular carotenoids mediated by the HDL cholesterol receptor SR-BI.
Title: Mechanism for the selective uptake of macular carotenoids mediated by the HDL cholesterol receptor SR-BI.
Twins' Macular Pigment Optical Density Assessment and Relation with SCARB1 Gene Polymorphism.
Title: Twins' Macular Pigment Optical Density Assessment and Relation with SCARB1 Gene Polymorphism.

Submit: New GeneRIF Correction See all GeneRIFs (286)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
High density lipoprotein cholesterol level quantitative trait locus 6 MedGen: C1853096 OMIM: 610762 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies common variants associated with circulating vitamin E levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SCARB1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A009B29 (e-PCR)
- UniSTS:32776

RH46525 (e-PCR)
- UniSTS:56628

RH11185 (e-PCR)
- UniSTS:1600

G59354 (e-PCR)
- UniSTS:136519

GDB:228077 (e-PCR)
- UniSTS:156253

NoName (e-PCR)
- UniSTS:66150

SHGC-111902 (e-PCR)
- UniSTS:168814

SCARB1_2043 (e-PCR)
- UniSTS:280979

SHGC-84469 (e-PCR)
- UniSTS:102822

NoName (e-PCR)
- UniSTS:483502

fe49f02.x1 (e-PCR)
- UniSTS:196554

G64578 (e-PCR)
- UniSTS:163807

RH64878 (e-PCR)
- UniSTS:31209

D11S3316 (e-PCR)
- UniSTS:152558

G32387 (e-PCR)
- UniSTS:116975

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol binding	TAS Traceable Author Statement more info	PubMed
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein A-I binding	IPI Inferred from Physical Interaction more info	PubMed
enables apolipoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables high-density lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables high-density lipoprotein particle receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables high-density lipoprotein particle receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables lipopolysaccharide immune receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables low-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables scavenger receptor activity	TAS Traceable Author Statement more info	PubMed
enables virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adhesion of symbiont to host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in cholesterol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol import	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol import	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in detection of lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in high-density lipoprotein particle remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in intestinal lipid absorption	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide transport	IDA Inferred from Direct Assay more info	PubMed
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cholesterol storage	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell migration	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of nitric-oxide synthase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in recognition of apoptotic cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in recognition of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of phagocytosis	IC Inferred by Curator more info	PubMed
involved_in regulation of phosphatidylcholine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in reverse cholesterol transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in vitamin transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	TAS Traceable Author Statement more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in lysosomal membrane	HDA more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: scavenger receptor class B member 1

Names: CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; scavenger receptor class B type III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028199.1 RefSeqGene

Range

5110..92118

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001082959.2 → NP_001076428.1 scavenger receptor class B member 1 isoform 2

See identical proteins and their annotated locations for NP_001076428.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC073593, AC126309

Consensus CDS

CCDS45008.1

UniProtKB/TrEMBL

A0A7P0T9I2

Related

ENSP00000343795.4, ENST00000339570.9

Conserved Domains (1) summary

pfam01130
Location:16 → 446

CD36; CD36 family
NM_001367981.1 → NP_001354910.1 scavenger receptor class B member 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AC073593, AC126309, BC022087

Consensus CDS

CCDS91769.1

UniProtKB/Swiss-Prot

F8W8N0, Q14016, Q52LZ5, Q6KFX4, Q8WTV0

UniProtKB/TrEMBL

A0A0S2Z3N2

Related

ENSP00000414979.2, ENST00000415380.6
NM_001367982.1 → NP_001354911.1 scavenger receptor class B member 1 isoform 4

Status: REVIEWED

Source sequence(s)

AC073593, AC126309, AK124112

UniProtKB/TrEMBL

B3KW46, B4DZ71

Related

ENSP00000444851.1, ENST00000544327.1
NM_001367983.1 → NP_001354912.1 scavenger receptor class B member 1 isoform 5

Status: REVIEWED

Source sequence(s)

AC073593, AC126309

UniProtKB/TrEMBL

A0A7P0T9I2
NM_001367984.1 → NP_001354913.1 scavenger receptor class B member 1 isoform 6

Status: REVIEWED

Source sequence(s)

AC073593, AC126309

UniProtKB/TrEMBL

A0A7P0T9I2
NM_001367985.1 → NP_001354914.1 scavenger receptor class B member 1 isoform 7

Status: REVIEWED

Source sequence(s)

AC073593, AC126309

UniProtKB/TrEMBL

A0A7P0T9I2
NM_001367986.1 → NP_001354915.1 scavenger receptor class B member 1 isoform 8

Status: REVIEWED

Source sequence(s)

AC073593, AC126309, BC143319

Consensus CDS

CCDS91770.1

UniProtKB/TrEMBL

A0A7P0T913, B7ZKQ9

Related

ENSP00000442862.1, ENST00000546215.5
NM_001367987.1 → NP_001354916.1 scavenger receptor class B member 1 isoform 9

Status: REVIEWED

Source sequence(s)

AC073593, AC126309

Consensus CDS

CCDS91771.1

UniProtKB/TrEMBL

A0A7P0T9I2, A0A7P0Z4E3

Related

ENSP00000505757.1, ENST00000680556.1
NM_001367988.1 → NP_001354917.1 scavenger receptor class B member 1 isoform 10

Status: REVIEWED

Source sequence(s)

AC073593, AC126309
NM_001367989.1 → NP_001354918.1 scavenger receptor class B member 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variant 1, encodes isoform 1.

Source sequence(s)

AC073593, AC126309

Consensus CDS

CCDS9259.1

UniProtKB/TrEMBL

A0A7P0T9I2

Conserved Domains (1) summary

pfam01130
Location:16 → 446

CD36; CD36 family
NM_005505.5 → NP_005496.4 scavenger receptor class B member 1 isoform 1

See identical proteins and their annotated locations for NP_005496.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 13 both encode the same isoform (1).

Source sequence(s)

AC073593, BC080647, BG770204, CA428516

Consensus CDS

CCDS9259.1

UniProtKB/TrEMBL

A0A7P0T9I2

Related

ENSP00000261693.6, ENST00000261693.11

Conserved Domains (1) summary

pfam01130
Location:16 → 446

CD36; CD36 family

RNA

NR_160416.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC073593, AC126309
NR_160417.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC073593, AC126309
NR_160418.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC073593, AC126309

Related

ENST00000679605.1
NR_160419.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC073593, AC126309
NR_160420.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC073593, AC126309
NR_160421.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC073593, AC126309
NR_160422.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC073593, AC126309
NR_160423.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC073593, AC126309
NR_160424.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC073593, AC126309

Related

ENST00000680926.1