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    ZFHX4 zinc finger homeobox 4 [ Gallus gallus (chicken) ]

    Gene ID: 395904, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ZFHX4provided by CGNC
    Official Full Name
    zinc finger homeobox 4provided by CGNC
    Primary source
    CGNC:11690
    See related
    Ensembl:ENSGALG00010003742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ZAX; ZFH-4
    Orthologs
    human mouse all
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    Genomic context

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    See ZFHX4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (119015780..119168424)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (119019681..119172329)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417686 Neighboring gene uncharacterized LOC124417687 Neighboring gene uncharacterized LOC124417688 Neighboring gene uncharacterized LOC112531870 Neighboring gene peroxisomal biogenesis factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiplex display polymerase chain reaction amplifies and resolves related sequences sharing a single moderately conserved domain. Peale FV Jr, et al. Anal Biochem, 1998 Feb 15. PMID 9473273
    2. Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. International Chicken Genome Sequencing Consortium. Nature, 2004 Dec 9. PMID 15592404
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger homeobox protein 4
    Names
    zinc finger homeodomain protein 4
    zinc-finger/apterous-related homeobox protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396678.1 → NP_001383607.1  zinc finger homeobox protein 4

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000043
      UniProtKB/Swiss-Prot
      O73590
      UniProtKB/TrEMBL
      A0A8V0XH71
      Related
      ENSGALP00010005063.1, ENSGALT00010008648.1
      Conserved Domains (4) summary
      smart00389
      Location:2195 → 2251
      HOX; Homeodomain
      PRK10263
      Location:2226 → 2530
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1520 → 1544
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1376 → 1396
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      119015780..119168424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_425925.8 → XP_425925.5  zinc finger homeobox protein 4 isoform X3

      UniProtKB/Swiss-Prot
      O73590
      Conserved Domains (4) summary
      smart00389
      Location:2191 → 2247
      HOX; Homeodomain
      PRK10263
      Location:2222 → 2526
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1516 → 1540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1372 → 1392
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_015282869.4 → XP_015138355.2  zinc finger homeobox protein 4 isoform X2

      UniProtKB/Swiss-Prot
      O73590
      Conserved Domains (4) summary
      smart00389
      Location:2194 → 2250
      HOX; Homeodomain
      PRK10263
      Location:2225 → 2529
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1519 → 1543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1375 → 1395
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_004939919.5 → XP_004939976.2  zinc finger homeobox protein 4 isoform X4

      UniProtKB/Swiss-Prot
      O73590
      Conserved Domains (4) summary
      smart00389
      Location:2169 → 2225
      HOX; Homeodomain
      PRK10263
      Location:2200 → 2504
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1494 → 1518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1350 → 1370
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_015282868.4 → XP_015138354.2  zinc finger homeobox protein 4 isoform X1

      UniProtKB/Swiss-Prot
      O73590
      UniProtKB/TrEMBL
      A0A8V0XH71
      Conserved Domains (4) summary
      smart00389
      Location:2195 → 2251
      HOX; Homeodomain
      PRK10263
      Location:2226 → 2530
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1520 → 1544
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1376 → 1396
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_004939918.5 → XP_004939975.2  zinc finger homeobox protein 4 isoform X1

      UniProtKB/Swiss-Prot
      O73590
      UniProtKB/TrEMBL
      A0A8V0XH71
      Conserved Domains (4) summary
      smart00389
      Location:2195 → 2251
      HOX; Homeodomain
      PRK10263
      Location:2226 → 2530
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1520 → 1544
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1376 → 1396
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      119019681..119172329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040665917.2 → XP_040521851.1  zinc finger homeobox protein 4 isoform X3

      UniProtKB/Swiss-Prot
      O73590
      Conserved Domains (4) summary
      smart00389
      Location:2191 → 2247
      HOX; Homeodomain
      PRK10263
      Location:2222 → 2526
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1516 → 1540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1372 → 1392
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_040665916.2 → XP_040521850.1  zinc finger homeobox protein 4 isoform X2

      UniProtKB/Swiss-Prot
      O73590
      Conserved Domains (4) summary
      smart00389
      Location:2194 → 2250
      HOX; Homeodomain
      PRK10263
      Location:2225 → 2529
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1519 → 1543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1375 → 1395
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_040665918.2 → XP_040521852.1  zinc finger homeobox protein 4 isoform X4

      UniProtKB/Swiss-Prot
      O73590
      Conserved Domains (4) summary
      smart00389
      Location:2169 → 2225
      HOX; Homeodomain
      PRK10263
      Location:2200 → 2504
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1494 → 1518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1350 → 1370
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_040665914.2 → XP_040521848.1  zinc finger homeobox protein 4 isoform X1

      UniProtKB/Swiss-Prot
      O73590
      UniProtKB/TrEMBL
      A0A8V0XH71
      Conserved Domains (4) summary
      smart00389
      Location:2195 → 2251
      HOX; Homeodomain
      PRK10263
      Location:2226 → 2530
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1520 → 1544
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1376 → 1396
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_040665915.2 → XP_040521849.1  zinc finger homeobox protein 4 isoform X1

      UniProtKB/Swiss-Prot
      O73590
      UniProtKB/TrEMBL
      A0A8V0XH71
      Conserved Domains (4) summary
      smart00389
      Location:2195 → 2251
      HOX; Homeodomain
      PRK10263
      Location:2226 → 2530
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:1520 → 1544
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1376 → 1396
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O73590.2 GenPept UniProtKB/Swiss-Prot:O73590

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