TF transferrin (ovotransferrin) [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: TFprovided by CGNC
Official Full Name: transferrin (ovotransferrin)provided by CGNC
Primary source: CGNC:49715
See related: Ensembl:ENSGALG00010024717
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: LTF; TFEW; conalbumin
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	9	NC_052540.1 (4254973..4265744, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	9	NC_052581.1 (4087532..4098298, complement)

Chromosome 9 - NC_052540.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

unfolding pathway and conformational stability of conalbumin
Title: pH-dependent conformational transitions in conalbumin (ovotransferrin), a metalloproteinase from hen egg white.
glycosylation of fetal & hen ovotransferrin differs; hypothesized to alter ovotransferrin recognition by carbohydrate binding lectins
Title: Change in glycosylation of chicken transferrin glycans biosynthesized during embryogenesis and primary culture of embryo hepatocytes.
The structure of ovotransferrin shows that the iron-binding site is located in the interdomain cleft in each lobe; differences in ovotransferrin structure cause changes to iron binding & uptake/release compared to lactotransferrin & transferrin.
Title: Crystal structure of diferric hen ovotransferrin at 2.4 A resolution.
At a pH where the protein net charge is negative (pH 8.0), the behavior of ovotransferrin at the air-water interface is more influenced by charge effects rather than bulk concentration effects.
Title: Unexpected differences in the behavior of ovotransferrin at the air-water interface at pH 6.5 and 8.0.
show both lobes are required for efficient iron binding and calculate binding kinetics.
Title: Physiological levels of binding and iron donation by complementary half-molecules of ovotransferrin to transferrin receptors of chick reticulocytes.
The exon structure of the ovotransferrin gene confirms the duplication event to produce two homologous domains that make up ovotransferrin
Title: Sequence of the chicken ovotransferrin gene.
ovotransferrin folds into two compact, iron-binding domains; the authors demonstrate that the duplicated domain structure is necessary to retain ovotransferrin in plasma and stop immediate loss via kidney filtration
Title: Evolutionary significance of the renal excretion of transferrin half-molecule fragments.
studied the carbohydrate and amino acid compositions of the ovotransferrin glycopeptides
Title: Investigation by 360-MHz 1H-nuclear-magnetic-resonance spectroscopy and methylation analysis of the single glycan chain of chicken ovotransferrin.
evidence suggests that conalbumin (ovotransferrin) and transferrin are products of the same gene, differing only in carbohydrate content
Title: The amino acid sequences of cysteic acid-containing peptides from performic acid-oxidized ovotransferrin.
Trp-Asn-Ile-Pro and Gly-Trp-Asn-Ile peptides of ovotransferrin showed the highest antioxidant activity.
Title: Identification of novel antioxidative peptides derived from a thermolytic hydrolysate of ovotransferrin by LC-MS/MS.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ovotransferrin

Names: allergen Gal d III; lactotransferrin; ovotransferrin BB type; ovotransferrin BC type; ovotransferrin CC type; serum transferrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205304.2 → NP_990635.2 ovotransferrin precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000240

UniProtKB/TrEMBL

Q4ADJ7

Related

ENSGALP00010037107.1, ENSGALT00010060348.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

4254973..4265744 complement

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GenBank, FASTA, Sequence Viewer (Graphics)