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    TFAP2A transcription factor AP-2 alpha [ Gallus gallus (chicken) ]

    Gene ID: 395982, updated on 10-Oct-2024

    Summary

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    Symbol
    TFAP2Aprovided by CGNC
    Full Name
    transcription factor AP-2 alphaprovided by CGNC
    Primary source
    CGNC:9685
    See related
    Ensembl:ENSGALG00010009668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    TFAP2
    Orthologs
    human mouse all
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    Genomic context

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    See TFAP2A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (63017677..63033999)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (62966466..62982767)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene male germ cell associated kinase Neighboring gene transmembrane protein 14C-like Neighboring gene glucosaminyl (N-acetyl) transferase 2 Neighboring gene uncharacterized LOC101749691 Neighboring gene uncharacterized LOC121109794 Neighboring gene heat shock transcription factor X1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chicken transcription factor AP-2: cloning, expression and its role in outgrowth of facial prominences and limb buds. Shen H, et al. Dev Biol, 1997 Aug 15. PMID 9268573
    2. AP-2 alpha suppresses skeletal myoblast proliferation and represses fibroblast growth factor receptor 1 promoter activity. Mitchell DL, et al. Exp Cell Res, 2010 Jan 15. PMID 19699737
    3. AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord. Xu X, et al. Neuroscience, 2017 Jan 6. PMID 27984181
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chicken TFAP2 expression was mapped from neural crest cell migration until E5.5. Transcripts were high in the migratory cranial neural crest cells, in facial and limb bud mesenchyme. Negative regulation of TFAP2 by all-trans-retinoic acid and positive regulation by FGF4 was shown in this study.
      Title: Chicken transcription factor AP-2: cloning, expression and its role in outgrowth of facial prominences and limb buds.
    2. Study systematically examined the expression profile of AP-2 family in the developing mouse and chick spinal cord and found that AP-2alpha and AP-2beta are specifically expressed in post-mitotic dorsal interneurons. Subsequent functional assessment in chick embryos demonstrated that AP-2alpha and AP-2beta have distinct functions in dorsal interneuron specification and differentiation.
      Title: AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord.
    3. Results indicate that AP-2 alpha is a transcriptional repressor of FGFR1 gene expression during skeletal myogenesis.
      Title: AP-2 alpha suppresses skeletal myoblast proliferation and represses fibroblast growth factor receptor 1 promoter activity.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor AP-2-alpha
    Names
    AP-2 transcription factor
    transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
    transcription factor AP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205094.2 → NP_990425.2  transcription factor AP-2-alpha

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000040
      UniProtKB/TrEMBL
      A0A8V0YBP0, O13111
      Related
      ENSGALP00010013358.1, ENSGALT00010023083.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      63017677..63033999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015275845.4 → XP_015131331.1  transcription factor AP-2-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y715, O13111
      Related
      ENSGALP00010013360.1, ENSGALT00010023085.1
      Conserved Domains (1) summary
      pfam03299
      Location:205 → 405
      TF_AP-2; Transcription factor AP-2

    2. XM_046918962.1 → XP_046774918.1  transcription factor AP-2-alpha isoform X4

    3. XM_015275844.4 → XP_015131330.1  transcription factor AP-2-alpha isoform X5

      UniProtKB/TrEMBL
      A0A8V0Y4R4
      Related
      ENSGALP00010013354.1, ENSGALT00010023078.1
      Conserved Domains (1) summary
      pfam03299
      Location:273 → 473
      TF_AP-2; Transcription factor AP-2

    4. XM_046918955.1 → XP_046774911.1  transcription factor AP-2-alpha isoform X6

    5. XM_046918956.1 → XP_046774912.1  transcription factor AP-2-alpha isoform X2

      UniProtKB/TrEMBL
      A0A8V0XYI6

    6. XM_015275847.4 → XP_015131333.1  transcription factor AP-2-alpha isoform X2

      UniProtKB/TrEMBL
      A0A8V0XYI6, O13111
      Related
      ENSGALP00010013352.1, ENSGALT00010023074.1
      Conserved Domains (1) summary
      pfam03299
      Location:203 → 403
      TF_AP-2; Transcription factor AP-2

    7. XM_015275848.3 → XP_015131334.1  transcription factor AP-2-alpha isoform X3

      UniProtKB/TrEMBL
      O13111
      Conserved Domains (1) summary
      pfam03299
      Location:203 → 403
      TF_AP-2; Transcription factor AP-2

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      62966466..62982767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910409.1 → XP_046766365.1  transcription factor AP-2-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y715

    2. XM_046910413.1 → XP_046766369.1  transcription factor AP-2-alpha isoform X4

    3. XM_046910408.1 → XP_046766364.1  transcription factor AP-2-alpha isoform X8

    4. XM_046910407.1 → XP_046766363.1  transcription factor AP-2-alpha isoform X7

    5. XM_046910410.1 → XP_046766366.1  transcription factor AP-2-alpha isoform X2

      UniProtKB/TrEMBL
      A0A8V0XYI6

    6. XM_046910411.1 → XP_046766367.1  transcription factor AP-2-alpha isoform X2

      UniProtKB/TrEMBL
      A0A8V0XYI6

    7. XM_046910412.1 → XP_046766368.1  transcription factor AP-2-alpha isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials