CDC25A cell division cycle 25A [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDC25Aprovided by HGNC
Official Full Name: cell division cycle 25Aprovided by HGNC
Primary source: HGNC:HGNC:1725
See related: Ensembl:ENSG00000164045 MIM:116947; AllianceGenome:HGNC:1725
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDC25A2
Summary: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 7.4), bone marrow (RPKM 4.6) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p21.31

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (48157146..48188417, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (48184306..48215830, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (48198636..48229907, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory mechanism of interaction between Y-box-binding protein 1 and heterogenous nuclear ribonucleoprotein K in cell division cycle 25a signal pathway and lung cancer metastasis.
Title: Regulatory mechanism of interaction between Y-box-binding protein 1 and heterogenous nuclear ribonucleoprotein K in cell division cycle 25a signal pathway and lung cancer metastasis.
Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition.
Title: Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition.
Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells.
Title: Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells.
miR-199a-5p inhibits the proliferation of hepatocellular carcinoma cells by regulating CDC25A to induce cell cycle arrest.
Title: miR-199a-5p inhibits the proliferation of hepatocellular carcinoma cells by regulating CDC25A to induce cell cycle arrest.
Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer.
Title: Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer.
FBXW8 regulates G1 and S phases of cell cycle progression by restricting beta-TrCP1 function.
Title: FBXW8 regulates G1 and S phases of cell cycle progression by restricting β-TrCP1 function.
Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
Title: Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
LINC00662 contributes to the progression and the radioresistance of cervical cancer by regulating miR-497-5p and CDC25A.
Title: LINC00662 contributes to the progression and the radioresistance of cervical cancer by regulating miR-497-5p and CDC25A.
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
Title: TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damage response.
Title: HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damage response.

Submit: New GeneRIF Correction See all GeneRIFs (123)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	Kinase Srk1 is required for the Vpr-mediated nuclear export of Cdc25	PubMed
	vpr	HIV-1 Vpr induces subcellular relocalization of Cdc25 from nuclear to cytoplasm and Vpr-induced nuclear exclusion of Cdc25 depends on the serine/threonine phosphorylation of Cdc25 and the presence of Rad24/14-3-3 protein	PubMed
Vpu	vpu	HIV-1 Vpu stabilizes cellular Cdc25A and differentially affects betaTrCP-mediated degradation events at different phases of the cell cycle	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH11459 (e-PCR)
- UniSTS:27146

RH80886 (e-PCR)
- UniSTS:91182

D3S4246 (e-PCR)
- UniSTS:9297

CDC25A_518.2 (e-PCR)
- UniSTS:280487

GDB:252110 (e-PCR)
- UniSTS:156331

D3S4167 (e-PCR)
- UniSTS:35769

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	TAS Traceable Author Statement more info
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	TAS Traceable Author Statement more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in response to radiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: M-phase inducer phosphatase 1

Names: CDC25 homolog A; dual specificity phosphatase CDC25A

NP_001780.2

EC 3.1.3.48

NP_963861.1

EC 3.1.3.48

XP_047305319.1

EC 3.1.3.48

XP_047305320.1

EC 3.1.3.48

XP_047305321.1

EC 3.1.3.48

XP_047305322.1

EC 3.1.3.48

XP_047305323.1

EC 3.1.3.48

XP_054204613.1

EC 3.1.3.48

XP_054204614.1

EC 3.1.3.48

XP_054204615.1

EC 3.1.3.48

XP_054204616.1

EC 3.1.3.48

XP_054204617.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001789.3 → NP_001780.2 M-phase inducer phosphatase 1 isoform a

See identical proteins and their annotated locations for NP_001780.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC104190, AC124916, AI917350, BC007401, BQ065803, BX392016

Consensus CDS

CCDS2760.1

UniProtKB/Swiss-Prot

P30304, Q8IZH5, Q96IL3, Q9H2F2

UniProtKB/TrEMBL

A8K3D9

Related

ENSP00000303706.3, ENST00000302506.8

Conserved Domains (2) summary

cd01530
Location:357 → 475

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:86 → 328

M-inducer_phosp; M-phase inducer phosphatase
NM_201567.2 → NP_963861.1 M-phase inducer phosphatase 1 isoform b

See identical proteins and their annotated locations for NP_963861.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC104190, AC124916, AI917350, AY137580, BC007401, BQ065803, BX392016

Consensus CDS

CCDS2761.1

UniProtKB/TrEMBL

A8K3D9

Related

ENSP00000343166.3, ENST00000351231.7

Conserved Domains (2) summary

cd01530
Location:317 → 435

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:86 → 288

M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

48157146..48188417 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047449366.1 → XP_047305322.1 M-phase inducer phosphatase 1 isoform X4

UniProtKB/TrEMBL

D8KXX0
XM_047449364.1 → XP_047305320.1 M-phase inducer phosphatase 1 isoform X2

UniProtKB/TrEMBL

K7N7S0
XM_047449365.1 → XP_047305321.1 M-phase inducer phosphatase 1 isoform X3
XM_047449363.1 → XP_047305319.1 M-phase inducer phosphatase 1 isoform X1

UniProtKB/Swiss-Prot

P30304, Q8IZH5, Q96IL3, Q9H2F2
XM_047449367.1 → XP_047305323.1 M-phase inducer phosphatase 1 isoform X5

Related

ENSP00000416483.1, ENST00000443342.5

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

48184306..48215830 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054348641.1 → XP_054204616.1 M-phase inducer phosphatase 1 isoform X4

UniProtKB/TrEMBL

D8KXX0
XM_054348639.1 → XP_054204614.1 M-phase inducer phosphatase 1 isoform X2

UniProtKB/TrEMBL

K7N7S0
XM_054348640.1 → XP_054204615.1 M-phase inducer phosphatase 1 isoform X3
XM_054348638.1 → XP_054204613.1 M-phase inducer phosphatase 1 isoform X1

UniProtKB/Swiss-Prot

P30304, Q8IZH5, Q96IL3, Q9H2F2
XM_054348642.1 → XP_054204617.1 M-phase inducer phosphatase 1 isoform X5