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    Slc25a28 solute carrier family 25, member 28 [ Mus musculus (house mouse) ]

    Gene ID: 246696, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc25a28provided by MGI
    Official Full Name
    solute carrier family 25, member 28provided by MGI
    Primary source
    MGI:MGI:2180509
    See related
    Ensembl:ENSMUSG00000040414 AllianceGenome:MGI:2180509
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mfrn2; Mrs3/4
    Summary
    Enables ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Located in mitochondrion. Is expressed in several structures, including genitourinary system; gut; immune system; liver; and lung. Orthologous to human SLC25A28 (solute carrier family 25 member 28). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 37.3), adrenal adult (RPKM 28.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a28 in Genome Data Viewer
    Location:
    19 C3; 19 36.67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43652240..43663320, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43663801..43675006, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene NK2 homeobox 3 Neighboring gene predicted gene, 34922 Neighboring gene STARR-seq mESC enhancer starr_46201 Neighboring gene predicted gene 4311 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:43749453-43749636 Neighboring gene cDNA sequence BC037704 Neighboring gene STARR-positive B cell enhancer ABC_E7661 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene cytochrome c oxidase assembly protein 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2.
      Title: Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2.
    2. SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL.
      Title: SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL.
    3. Microglial SLC25A28 Deficiency Ameliorates the Brain Injury After Intracerebral Hemorrhage in Mice by Restricting Aerobic Glycolysis.
      Title: Microglial SLC25A28 Deficiency Ameliorates the Brain Injury After Intracerebral Hemorrhage in Mice by Restricting Aerobic Glycolysis.
    4. Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis.
      Title: Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis.
    5. The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice.
      Title: The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice.
    6. The cis-regulatory modules (CRMs) that control expression of the Mfrn genes, were mapped.
      Title: Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis.
    7. Mitoferrin 1 and mitoferrin 2 contribute to mitochondrial iron delivery in a variety of cells.
      Title: Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • 2210403D18Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ferrous iron transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitoferrin-2
    Names
    mitochondrial RNA-splicing protein 3/4 homolog
    mitochondrial iron transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356944.1 → NP_001343873.1  mitoferrin-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1 The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC138790, AF377993, BE849400
      Conserved Domains (1) summary
      pfam00153
      Location:1 → 66
      Mito_carr; Mitochondrial carrier protein

    2. NM_145156.1 → NP_660138.1  mitoferrin-2 isoform 1

      See identical proteins and their annotated locations for NP_660138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC138790, AF377994, BE849400
      Consensus CDS
      CCDS29834.1
      UniProtKB/Swiss-Prot
      Q8K4J8, Q8K4J9, Q8R0Z5, Q8R578
      Related
      ENSMUSP00000036913.8, ENSMUST00000046038.9
      Conserved Domains (1) summary
      pfam00153
      Location:71 → 161
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      43652240..43663320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318202.3 → XP_017173691.1  mitoferrin-2 isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:76 → 160
      Mito_carr; Mitochondrial carrier protein

    2. XM_006527097.3 → XP_006527160.1  mitoferrin-2 isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:4 → 82
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0Z5.1 GenPept UniProtKB/Swiss-Prot:Q8R0Z5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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