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    gja8.S gap junction protein alpha 8 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 100381091, updated on 4-Nov-2024

    Summary

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    Official Symbol
    gja8.S
    Official Full Name
    gap junction protein alpha 8 S homeolog
    Primary source
    Xenbase:XB-GENE-866236
    Locus tag
    XELAEV_18014382mg
    See related
    EnsemblRapid:ENSXLAG00005032572 AllianceGenome:Xenbase:XB-GENE-866236
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    cx50; gja8; mp70; connexin50
    Summary
    Predicted to enable gap junction channel activity. Predicted to act upstream of or within cell-cell signaling and gap junction-mediated intercellular transport. Predicted to be located in gap junction and plasma membrane. Predicted to be part of connexin complex. Human ortholog(s) of this gene implicated in cataract and cataract 1 multiple types. Orthologous to human GJA8 (gap junction protein alpha 8). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See gja8.S in Genome Data Viewer
    Location:
    chromosome: 2S
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (24223056..24233687)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (24132536..24140290)

    Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108709261 Neighboring gene small nucleolar RNA SNORA13 Neighboring gene small nucleolar RNA SNORA13 Neighboring gene PDZ domain containing 1 S homeolog Neighboring gene B- and T-lymphocyte attenuator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of Connexin50 and Connexin46 by PI3K signaling. Martinez JM, et al. FEBS Lett, 2015 May 22. PMID 25935417, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables gap junction channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gap junction-mediated intercellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of connexin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gap junction alpha-8 protein
    Names
    alpha8 connexin
    connexin 50
    gap junction protein, alpha 8, 50kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      24223056..24233687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018248948.2 → XP_018104437.1  gap junction alpha-8 protein

      UniProtKB/TrEMBL
      A0A8J0UJE6
      Related
      ENSXLAP00005097579.1, ENSXLAT00005099371.1
    Nucleotide Protein Strain
    Heading Accession and Version

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