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    Adat2 adenosine deaminase, tRNA-specific 2 [ Mus musculus (house mouse) ]

    Gene ID: 66757, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Adat2provided by MGI
    Official Full Name
    adenosine deaminase, tRNA-specific 2provided by MGI
    Primary source
    MGI:MGI:1914007
    See related
    Ensembl:ENSMUSG00000019808 AllianceGenome:MGI:1914007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Deadc1; 4933426M09Rik
    Summary
    Predicted to enable tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Orthologous to human ADAT2 (adenosine deaminase tRNA specific 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.0), CNS E11.5 (RPKM 4.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adat2 in Genome Data Viewer
    Location:
    10 A2; 10 4.94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (13428651..13439120)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13552907..13563376)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phosphatase and actin regulator 2 Neighboring gene predicted gene, 46211 Neighboring gene STARR-seq mESC enhancer starr_25813 Neighboring gene STARR-seq mESC enhancer starr_25814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13220839-13220948 Neighboring gene STARR-seq mESC enhancer starr_25815 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13272745-13273072 Neighboring gene fucosidase, alpha-L- 2, plasma Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene RIKEN cDNA A730010A20 gene Neighboring gene STARR-seq mESC enhancer starr_25816 Neighboring gene androgen-induced 1 Neighboring gene predicted gene, 53613

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination. Ramos-Morales E, et al. Nucleic Acids Res, 2021 Jun 21. PMID 34057470, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.
      Title: The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tRNA-specific adenosine-34 deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine-34 deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA wobble adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble adenosine to inosine editing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-specific adenosine deaminase 2
    Names
    adenosine deaminase, tRNA-specific 2, TAD2 homolog
    deaminase domain containing 1
    deaminase domain-containing protein 1
    tRNA-specific adenosine-34 deaminase subunit ADAT2
    NP_080024.3
    XP_011241502.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025748.4 → NP_080024.3  tRNA-specific adenosine deaminase 2

      See identical proteins and their annotated locations for NP_080024.3

      Status: VALIDATED

      Source sequence(s)
      AC153979, AK016938, AK021291
      Consensus CDS
      CCDS35847.1
      UniProtKB/Swiss-Prot
      Q6P6J0, Q9CX14
      Related
      ENSMUSP00000019944.9, ENSMUST00000019944.9
      Conserved Domains (1) summary
      COG0590
      Location:23 → 173
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      13428651..13439120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243200.3 → XP_011241502.1  tRNA-specific adenosine deaminase 2 isoform X1

      Conserved Domains (1) summary
      cd01285
      Location:26 → 116
      nucleoside_deaminase; Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6J0.1 GenPept UniProtKB/Swiss-Prot:Q6P6J0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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