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    Mroh2b maestro heat-like repeat family member 2B [ Mus musculus (house mouse) ]

    Gene ID: 223825, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mroh2bprovided by MGI
    Official Full Name
    maestro heat-like repeat family member 2Bprovided by MGI
    Primary source
    MGI:MGI:1921905
    See related
    Ensembl:ENSMUSG00000022155 AllianceGenome:MGI:1921905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPIF; Heatr7b2; 4930455B06Rik
    Summary
    Involved in protein kinase A signaling. Located in acrosomal vesicle and sperm midpiece. Orthologous to human MROH2B (maestro heat like repeat family member 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 78.8) See more
    Orthologs
    human all
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    Genomic context

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    See Mroh2b in Genome Data Viewer
    Location:
    15 A1; 15 1.98 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (4927697..4991689)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (4898215..4962207)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37833 Neighboring gene complement component 6 Neighboring gene STARR-seq mESC enhancer starr_37834 Neighboring gene STARR-seq mESC enhancer starr_37835 Neighboring gene STARR-seq mESC enhancer starr_37836 Neighboring gene STARR-seq mESC enhancer starr_37837 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_37838 Neighboring gene STARR-seq mESC enhancer starr_37841 Neighboring gene complement component 7 Neighboring gene predicted gene, 25652 Neighboring gene caspase recruitment domain family, member 6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation. Stanger SJ, et al. FASEB J, 2016 Aug. PMID 27105888
    2. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. Oduru S, et al. BMC Genomics, 2003 Jun 3. PMID 12783626, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • FLJ40243

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein kinase A signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    maestro heat-like repeat-containing protein family member 2B
    Names
    HEAT repeat-containing protein 7B2
    XVHEAT repeat family member 7B2
    sperm PKA interacting factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166066.1 → NP_001159538.1  maestro heat-like repeat-containing protein family member 2B

      See identical proteins and their annotated locations for NP_001159538.1

      Status: VALIDATED

      Source sequence(s)
      AC115877, AC117588
      Consensus CDS
      CCDS49572.1
      UniProtKB/Swiss-Prot
      A0A096XFP7, A0A096XFP8, Q7M6Y6
      Related
      ENSMUSP00000036148.8, ENSMUST00000045736.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      4927697..4991689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248514.1 → XP_030104374.1  maestro heat-like repeat-containing protein family member 2B isoform X1

      UniProtKB/Swiss-Prot
      A0A096XFP7, A0A096XFP8, Q7M6Y6

    2. XM_006519981.5 → XP_006520044.1  maestro heat-like repeat-containing protein family member 2B isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M6Y6.2 GenPept UniProtKB/Swiss-Prot:Q7M6Y6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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