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    Mepce methylphosphate capping enzyme [ Mus musculus (house mouse) ]

    Gene ID: 231803, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mepceprovided by MGI
    Official Full Name
    methylphosphate capping enzymeprovided by MGI
    Primary source
    MGI:MGI:106477
    See related
    Ensembl:ENSMUSG00000029726 AllianceGenome:MGI:106477
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bcdin3; D5Wsu46e
    Summary
    Predicted to enable 7SK snRNA binding activity and RNA 5'-gamma-phosphate methyltransferase activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in nucleus. Predicted to be part of 7SK snRNP. Is expressed in several structures, including adrenal gland; alimentary system; brain; early conceptus; and genitourinary system. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.4), thymus adult (RPKM 24.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mepce in Genome Data Viewer
    Location:
    5 G2; 5 76.7 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137780168..137785915, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137781906..137786701, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57848 Neighboring gene sperm acrosome developmental regulator Neighboring gene STARR-positive B cell enhancer ABC_E4797 Neighboring gene STARR-positive B cell enhancer ABC_E857 Neighboring gene STARR-positive B cell enhancer ABC_E1312 Neighboring gene protein phosphatase 1, regulatory subunit 35 Neighboring gene STARR-positive B cell enhancer ABC_E4798 Neighboring gene zinc finger, CW type with PWWP domain 1 Neighboring gene STARR-seq mESC enhancer starr_14656 Neighboring gene paired immunoglobin-like type 2 receptor alpha Neighboring gene paired immunoglobin-like type 2 receptor beta 1 Neighboring gene predicted gene, 36551

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Okamura D, et al. Genes Dev, 2012 Nov 15. PMID 23154982, Free PMC Article
    2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28888, MGC30590

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 7SK snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 7SK snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA 5'-gamma-phosphate methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA 5'-gamma-phosphate methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of chromatin binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of snRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in snRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in snRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of 7SK snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of 7SK snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    7SK snRNA methylphosphate capping enzyme
    Names
    bin3, bicoid-interacting 3, homolog
    NP_001411556.1
    NP_659162.3
    XP_017176362.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424627.1 → NP_001411556.1  7SK snRNA methylphosphate capping enzyme isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125063

    2. NM_144913.4 → NP_659162.3  7SK snRNA methylphosphate capping enzyme isoform 1

      See identical proteins and their annotated locations for NP_659162.3

      Status: VALIDATED

      Source sequence(s)
      AC125063
      Consensus CDS
      CCDS39337.1
      UniProtKB/Swiss-Prot
      Q2YFS5, Q3U465, Q3UT64, Q8K3A9, Q91W35
      Related
      ENSMUSP00000031740.10, ENSMUST00000031740.16
      Conserved Domains (2) summary
      cd02440
      Location:423 → 593
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam06859
      Location:552 → 660
      Bin3; Bicoid-interacting protein 3 (Bin3)

    RNA

    1. NR_188806.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125063

    2. NR_188808.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125063

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137780168..137785915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320873.1 → XP_017176362.1  7SK snRNA methylphosphate capping enzyme isoform X1

      Conserved Domains (2) summary
      cd02440
      Location:423 → 593
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam06859
      Location:552 → 650
      Bin3; Bicoid-interacting protein 3 (Bin3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3A9.2 GenPept UniProtKB/Swiss-Prot:Q8K3A9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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