U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rps5 ribosomal protein S5 [ Mus musculus (house mouse) ]

    Gene ID: 20103, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rps5provided by MGI
    Official Full Name
    ribosomal protein S5provided by MGI
    Primary source
    MGI:MGI:1097682
    See related
    Ensembl:ENSMUSG00000012848 AllianceGenome:MGI:1097682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    A structural constituent of ribosome. Predicted to be involved in regulation of translational fidelity; ribosomal small subunit assembly; and translation. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in several structures, including brain; embryo ectoderm; genitourinary system; gut; and sensory organ. Orthologous to human RPS5 (ribosomal protein S5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 1722.8), large intestine adult (RPKM 951.0) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rps5 in Genome Data Viewer
    Location:
    7 A1; 7 7.69 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12656223..12660613)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12922311..12926686)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6510 Neighboring gene zinc finger protein 128 Neighboring gene STARR-positive B cell enhancer mm9_chr7:13482923-13483223 Neighboring gene zinc finger and SCAN domain containing 22 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13495643-13495826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13507414-13507597 Neighboring gene ring finger protein 225 Neighboring gene predicted gene, 26325 Neighboring gene RIKEN cDNA 1810019N24 gene Neighboring gene STARR-seq mESC enhancer starr_18063 Neighboring gene predicted gene 29638

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cloning, sequencing and expression in MEL cells of a cDNA encoding the mouse ribosomal protein S5. Vanegas N, et al. Biochim Biophys Acta, 1997 Jun 5. PMID 9202169
    2. The potential role of ribosomal protein S5 on cell cycle arrest and initiation of murine erythroleukemia cell differentiation. Matragkou CN, et al. J Cell Biochem, 2008 Jul 1. PMID 18288641
    3. Exosomes from adipose-derived stem cells regulate macrophage polarization and accelerate diabetic wound healing via the circ-Rps5/miR-124-3p axis. Yin D, et al. Immun Inflamm Dis, 2024 Jun. PMID 38888351, Free PMC Article
    4. On the intracellular trafficking of mouse S5 ribosomal protein from cytoplasm to nucleoli. Matragkou Ch, et al. J Mol Biol, 2009 Oct 9. PMID 19631221
    5. Genetic manipulation of RPS5 gene expression modulates the initiation of commitment of MEL cells to erythroid maturation: Implications in understanding ribosomopathies. Vizirianakis IS, et al. Int J Oncol, 2015 Jul. PMID 25998414

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomes from adipose-derived stem cells regulate macrophage polarization and accelerate diabetic wound healing via the circ-Rps5/miR-124-3p axis.
      Title: Exosomes from adipose-derived stem cells regulate macrophage polarization and accelerate diabetic wound healing via the circ-Rps5/miR-124-3p axis.
    2. Findings support the concept that genetic manipulation of RPS5 gene expression level (up- and/or downregulation) critically affects the potential of murine erythroleukemia cells to fully complete their erythroid maturation program in vitro.
      Title: Genetic manipulation of RPS5 gene expression modulates the initiation of commitment of MEL cells to erythroid maturation: Implications in understanding ribosomopathies.
    3. The results indicate that rpS5 protein enters the nucleus via the region 38-50 aa that forms a random coil as revealed by molecular dynamic simulation.
      Title: On the intracellular trafficking of mouse S5 ribosomal protein from cytoplasm to nucleoli.
    4. deregulation of RPS5 gene expression (constitutive expression) affects RPS5 protein level and delays both the onset of initiation of erythroid maturation and entrance in cell cycle arrest in inducer-treated MEL cells.
      Title: The potential role of ribosomal protein S5 on cell cycle arrest and initiation of murine erythroleukemia cell differentiation.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational fidelity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    small ribosomal subunit protein uS7
    Names
    40S ribosomal protein S5
    S5 ribosomal protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417226.1 → NP_001404155.1  small ribosomal subunit protein uS7

      Status: VALIDATED

      Source sequence(s)
      AC107704
      UniProtKB/Swiss-Prot
      O08607, P97461, Q91V55
      Related
      ENSMUSP00000121961.3, ENSMUST00000137329.4

    2. NM_009095.3 → NP_033121.2  small ribosomal subunit protein uS7

      See identical proteins and their annotated locations for NP_033121.2

      Status: VALIDATED

      Source sequence(s)
      AC107704
      Consensus CDS
      CCDS20817.1
      UniProtKB/Swiss-Prot
      O08607, P97461, Q91V55
      UniProtKB/TrEMBL
      D3Z1S8
      Related
      ENSMUSP00000004554.8, ENSMUST00000004554.14
      Conserved Domains (1) summary
      cd14867
      Location:18 → 204
      uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12656223..12660613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152810.1 → XP_036008703.1  small ribosomal subunit protein uS7 isoform X1

      UniProtKB/Swiss-Prot
      O08607, P97461, Q91V55
      UniProtKB/TrEMBL
      D3Z1S8
      Related
      ENSMUSP00000104179.2, ENSMUST00000108539.8
      Conserved Domains (1) summary
      cd14867
      Location:18 → 204
      uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97461.4 GenPept UniProtKB/Swiss-Prot:P97461

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous