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    MATK megakaryocyte-associated tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 4145, updated on 14-Nov-2024

    Summary

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    Official Symbol
    MATKprovided by HGNC
    Official Full Name
    megakaryocyte-associated tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:6906
    See related
    Ensembl:ENSG00000007264 MIM:600038; AllianceGenome:HGNC:6906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHK; CTK; HYL; Lsk; HYLTK; HHYLTK
    Summary
    The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 4.5), bone marrow (RPKM 3.5) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MATK in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (3777973..3801799, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (3757233..3781064, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3777971..3801797, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3770519-3771018 Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene retina and anterior neural fold homeobox 2 Neighboring gene MPRA-validated peak3254 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3784812-3785807 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3787338-3787536 Neighboring gene MPRA-validated peak3255 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3809153-3809388 Neighboring gene zinc finger RNA binding protein 2 Neighboring gene Sharpr-MPRA regulatory region 15218 Neighboring gene MPRA-validated peak3257 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3831251-3831840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3843229-3843728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3849523-3850024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3871123-3871622 Neighboring gene ferritin light chain pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation.
      Title: CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation.
    2. After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1.
      Title: IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells.
    3. CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma.
      Title: Csk homologous kinase inhibits CXCL12-CXCR4 signaling in neuroblastoma.
    4. These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells.
      Title: Decreased CHK protein levels are associated with Src activation in colon cancer cells.
    5. Progesterone increases MATK in mast cells and reducs cell proliferation.
      Title: Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation.
    6. Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms
      Title: Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells.
    7. CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase
      Title: Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK.
    8. Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation.
      Title: Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus.
    9. Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation.
      Title: Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase.
    10. ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines
      Title: Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC1708, MGC2101, DKFZp434N1212

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    megakaryocyte-associated tyrosine-protein kinase
    Names
    CSK homologous kinase
    Csk-homologous kinase
    Csk-type protein tyrosine kinase
    HYL tyrosine kinase
    hematopoietic consensus tyrosine-lacking kinase
    hydroxyaryl-protein kinase
    leukocyte carboxyl-terminal src kinase related
    protein kinase HYL
    tyrosine kinase MATK
    tyrosine-protein kinase CTK
    tyrosylprotein kinase
    NP_002369.2
    NP_647611.1
    NP_647612.1
    XP_011526320.1
    XP_047294798.1
    XP_047294799.1
    XP_054177010.1
    XP_054177011.1
    XP_054177012.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002378.4 → NP_002369.2  megakaryocyte-associated tyrosine-protein kinase isoform b

      See identical proteins and their annotated locations for NP_002369.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate region at the 5' end of the coding region and lacks two exons in the coding region, as compared to variant 1. The encoded isoform b has a slightly longer and unique N-terminus compared to isoform a.
      Source sequence(s)
      AK055395, BC000114, DA592994
      Consensus CDS
      CCDS12113.1
      UniProtKB/TrEMBL
      B2RDR6, K7EQY5
      Related
      ENSP00000378485.1, ENST00000395045.6
      Conserved Domains (4) summary
      cd09937
      Location:119 → 216
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd11811
      Location:51 → 109
      SH3_CHK; Src Homology 3 domain of CSK homologous kinase
      smart00221
      Location:236 → 479
      STYKc; Protein kinase; unclassified specificity
      cd05083
      Location:229 → 482
      PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase

    2. NM_139354.3 → NP_647611.1  megakaryocyte-associated tyrosine-protein kinase isoform c

      See identical proteins and their annotated locations for NP_647611.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, and utilizes a downstream in-frame start codon, compared to variant 1. Isoform c has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AL137754, BG396388, BQ109562, X77278
      Consensus CDS
      CCDS42468.1
      UniProtKB/TrEMBL
      Q16176
      Related
      ENSP00000378481.1, ENST00000395040.6
      Conserved Domains (3) summary
      cd09937
      Location:77 → 174
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd11811
      Location:9 → 67
      SH3_CHK; Src Homology 3 domain of CSK homologous kinase
      cd05083
      Location:187 → 440
      PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase

    3. NM_139355.3 → NP_647612.1  megakaryocyte-associated tyrosine-protein kinase isoform a

      See identical proteins and their annotated locations for NP_647612.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform a.
      Source sequence(s)
      BC000114, BG396388, BM925586
      Consensus CDS
      CCDS12114.1
      UniProtKB/Swiss-Prot
      B3KNZ9, P42679, Q9NST8
      UniProtKB/TrEMBL
      B2RDR6, F1T0G6, K7EQY5
      Related
      ENSP00000308734.5, ENST00000310132.11
      Conserved Domains (3) summary
      cd09937
      Location:118 → 215
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd11811
      Location:50 → 108
      SH3_CHK; Src Homology 3 domain of CSK homologous kinase
      cd05083
      Location:228 → 481
      PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      3777973..3801799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438843.1 → XP_047294799.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

    2. XM_047438842.1 → XP_047294798.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

    3. XM_011528018.2 → XP_011526320.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_011526320.1

      UniProtKB/Swiss-Prot
      B3KNZ9, P42679, Q9NST8
      UniProtKB/TrEMBL
      B2RDR6, F1T0G6, K7EQY5
      Conserved Domains (3) summary
      cd09937
      Location:118 → 215
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd11811
      Location:50 → 108
      SH3_CHK; Src Homology 3 domain of CSK homologous kinase
      cd05083
      Location:228 → 481
      PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      3757233..3781064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321037.1 → XP_054177012.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

    2. XM_054321036.1 → XP_054177011.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

    3. XM_054321035.1 → XP_054177010.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      B3KNZ9, P42679, Q9NST8
      UniProtKB/TrEMBL
      F1T0G6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42679.1 GenPept UniProtKB/Swiss-Prot:P42679

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