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    Slc7a11 solute carrier family 7 member 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310392, updated on 2-Nov-2024

    Summary

    Official Symbol
    Slc7a11provided by RGD
    Official Full Name
    solute carrier family 7 member 11provided by RGD
    Primary source
    RGD:1309275
    See related
    EnsemblRapid:ENSRNOG00000010210 AllianceGenome:RGD:1309275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable L-kynurenine transmembrane transporter activity and cystine:glutamate antiporter activity. Involved in lens fiber cell differentiation; response to nicotine; and response to oxidative stress. Predicted to be located in several cellular components, including astrocyte projection; brush border membrane; and cell surface. Orthologous to human SLC7A11 (solute carrier family 7 member 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 682.1), Brain (RPKM 145.8) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Slc7a11 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (136532912..136668560, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (134382002..134517622, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (139453774..139528479, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18A, pseudogene 6 Neighboring gene ADRM1 26S proteasome ubiquitin receptor, pseudogene 1 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120100816

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-kynurenine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cystine:glutamate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-cystine transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within L-glutamate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-kynurenine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dipeptide import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glutathione transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular glutamate homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lens fiber cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within limb development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ferroptosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of AMPA glutamate receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of glutathione biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of melanin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to redox state ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within striatum development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in astrocyte projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cystine/glutamate transporter
    Names
    solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107673.3NP_001101143.2  cystine/glutamate transporter

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AB70, D4ADU2
      Related
      ENSRNOP00000091221.2, ENSRNOT00000114420.3
      Conserved Domains (2) summary
      TIGR00911
      Location:1498
      2A0308; L-type amino acid transporter
      cl00456
      Location:42291
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      136532912..136668560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102260.2XP_038958188.1  cystine/glutamate transporter isoform X3

      UniProtKB/TrEMBL
      D4ADU2
      Conserved Domains (1) summary
      TIGR00911
      Location:1440
      2A0308; L-type amino acid transporter
    2. XM_039102258.2XP_038958186.1  cystine/glutamate transporter isoform X1

      UniProtKB/TrEMBL
      D4ADU2
      Related
      ENSRNOP00000098235.1, ENSRNOT00000120596.2
      Conserved Domains (1) summary
      TIGR00911
      Location:1482
      2A0308; L-type amino acid transporter
    3. XM_063281786.1XP_063137856.1  cystine/glutamate transporter isoform X4

    4. XM_039102259.2XP_038958187.1  cystine/glutamate transporter isoform X2

      UniProtKB/TrEMBL
      D4ADU2
      Conserved Domains (1) summary
      TIGR00911
      Location:1483
      2A0308; L-type amino acid transporter