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    LENG9 leukocyte receptor cluster member 9 [ Homo sapiens (human) ]

    Gene ID: 94059, updated on 3-Nov-2024

    Summary

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    Official Symbol
    LENG9provided by HGNC
    Official Full Name
    leukocyte receptor cluster member 9provided by HGNC
    Primary source
    HGNC:HGNC:16306
    See related
    Ensembl:ENSG00000275183 AllianceGenome:HGNC:16306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    mouse all
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    Genomic context

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    See LENG9 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54461732..54463778, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57555012..57557061, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54972912..54974961, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LIM domain-containing protein A-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54933359-54934162 Neighboring gene tweety family member 1 Neighboring gene Sharpr-MPRA regulatory region 3780 Neighboring gene LENG8 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54960127-54961034 Neighboring gene leukocyte receptor cluster member 8 Neighboring gene CDC42 effector protein 5 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55018677-55019177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55020667-55021482 Neighboring gene leukocyte associated immunoglobulin like receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. Wende H, et al. Immunogenetics, 2000 Jul. PMID 10941842
    2. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article
    3. High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA. Jiang L, et al. mSystems, 2023 Aug 31. PMID 37314180, Free PMC Article
    4. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. Llères D, et al. EMBO Rep, 2010 Jun. PMID 20467437, Free PMC Article
    5. Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis. Li H, et al. Cell Rep, 2022 Dec 20. PMID 36543142

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte receptor cluster member 9
    Names
    leukocyte receptor cluster (LRC) member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301782.2 → NP_001288711.1  leukocyte receptor cluster member 9

      Status: VALIDATED

      Source sequence(s)
      AC245884, CA450132
      Consensus CDS
      CCDS77358.1
      UniProtKB/TrEMBL
      A0A087WVD1
      Related
      ENSP00000479355.1, ENST00000611161.2
      Conserved Domains (3) summary
      smart00356
      Location:24 → 39
      ZnF_C3H1; zinc finger
      pfam10469
      Location:297 → 477
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
      cl00661
      Location:87 → 138
      DUF504; Protein of unknown function (DUF504)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54461732..54463778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      368246..370292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      366320..368654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045181401.2 → XP_045037336.1  leukocyte receptor cluster member 9 isoform X1

      UniProtKB/Swiss-Prot
      B2VAM3, Q96B70
      Conserved Domains (3) summary
      pfam04457
      Location:87 → 160
      DUF504; Protein of unknown function (DUF504)
      pfam18345
      Location:46 → 61
      zf_CCCH_4; Zinc finger domain
      cl26521
      Location:320 → 500
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      443926..446260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045181402.2 → XP_045037337.1  leukocyte receptor cluster member 9 isoform X2

      UniProtKB/Swiss-Prot
      B2VAM3, Q96B70
      Conserved Domains (3) summary
      pfam04457
      Location:87 → 160
      DUF504; Protein of unknown function (DUF504)
      pfam18345
      Location:46 → 61
      zf_CCCH_4; Zinc finger domain
      cl26521
      Location:320 → 500
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57555012..57557061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198988.2: Suppressed sequence

      Description
      NM_198988.2: This RefSeq was removed because there were mismatches and indels compared to available sequence data. One of the mismatches resulted in the use of an upstream start codon, which is not supported by available homology data.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96B70.2 GenPept UniProtKB/Swiss-Prot:Q96B70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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