COPZ2 COPI coat complex subunit zeta 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: COPZ2provided by HGNC
Official Full Name: COPI coat complex subunit zeta 2provided by HGNC
Primary source: HGNC:HGNC:19356
See related: Ensembl:ENSG00000005243 MIM:615526; AllianceGenome:HGNC:19356
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: zeta2-COP
Summary: This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]
Expression: Broad expression in fat (RPKM 13.1), prostate (RPKM 4.4) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (48026167..48048053, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (48887980..48909899, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (46103533..46115159, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The knockdown of COPZ1, but not of COPZ2 encoding isoform coatomer protein complex zeta2, caused Golgi apparatus collapse, blocked autophagy, and induced apoptosis in both proliferating and nondividing tumor cells.
Title: Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.
The solution structure of a truncated form (residues 1-149; zeta-COP149) of human zeta-COP (total 177 residues), is reported.
Title: Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32 EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93052 (e-PCR)
- UniSTS:85000

COPZ2_9687 (e-PCR)
- UniSTS:471398

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	NAS Non-traceable Author Statement more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COPI vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPI vesicle coat	IDA Inferred from Direct Assay more info	PubMed
part_of COPI vesicle coat	NAS Non-traceable Author Statement more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in cis-Golgi network	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in transport vesicle	TAS Traceable Author Statement more info

General protein information

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Preferred Names: coatomer subunit zeta-2

Names: coatomer protein complex subunit zeta 2; nonclathrin coat protein zeta-COP; zeta-2 COP; zeta-2-coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016429.4 → NP_057513.1 coatomer subunit zeta-2

See identical proteins and their annotated locations for NP_057513.1

Status: REVIEWED

Source sequence(s)

BC015924, BQ002984, HY179834

Consensus CDS

CCDS74092.1

UniProtKB/Swiss-Prot

Q9P299

Related

ENSP00000480707.1, ENST00000621465.5

Conserved Domains (1) summary

cd14829
Location:47 → 178

Zeta-COP; zeta subunit of the F-COPI complex

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

48026167..48048053 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011524874.3 → XP_011523176.1 coatomer subunit zeta-2 isoform X4

Conserved Domains (1) summary

cl38905
Location:47 → 152

longin-like; Longin-like domains
XM_047436209.1 → XP_047292165.1 coatomer subunit zeta-2 isoform X5

Related

ENSP00000464484.1, ENST00000584955.5
XM_047436207.1 → XP_047292163.1 coatomer subunit zeta-2 isoform X2
XM_047436208.1 → XP_047292164.1 coatomer subunit zeta-2 isoform X3
XM_047436206.1 → XP_047292162.1 coatomer subunit zeta-2 isoform X1