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    Prune2 prune homolog 2 [ Mus musculus (house mouse) ]

    Gene ID: 353211, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prune2provided by MGI
    Official Full Name
    prune homolog 2provided by MGI
    Primary source
    MGI:MGI:1925004
    See related
    Ensembl:ENSMUSG00000039126 AllianceGenome:MGI:1925004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bmcc1; Olfaxin; mKIAA0367; 6330414G02Rik; A230083H22Rik; A330102H22Rik
    Summary
    Predicted to enable pyrophosphatase activity. Predicted to be involved in apoptotic process. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urinary system. Orthologous to human PRUNE2 (prune homolog 2 with BCH domain). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 10.0), frontal lobe adult (RPKM 5.5) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prune2 in Genome Data Viewer
    Location:
    19 B; 19 12.34 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (16933033..17201322)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (16955668..17223963)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene forkhead box B2 Neighboring gene predicted gene, 32341 Neighboring gene STARR-seq mESC enhancer starr_45670 Neighboring gene STARR-seq mESC enhancer starr_45671 Neighboring gene STARR-seq mESC enhancer starr_45673 Neighboring gene STARR-seq mESC enhancer starr_45676 Neighboring gene STARR-positive B cell enhancer ABC_E4271 Neighboring gene STARR-seq mESC enhancer starr_45678 Neighboring gene STARR-seq mESC enhancer starr_45679 Neighboring gene glucosaminyl (N-acetyl) transferase 1, core 2 Neighboring gene STARR-seq mESC enhancer starr_45680 Neighboring gene STARR-positive B cell enhancer ABC_E3246 Neighboring gene riboflavin kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Odor preference and olfactory memory are impaired in Olfaxin-deficient mice. Islam S, et al. Brain Res, 2018 Jun 1. PMID 29571668
    2. The expression and localization of Prune2 mRNA in the central nervous system. Li S, et al. Neurosci Lett, 2011 Oct 10. PMID 21893162
    3. Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system. Li S, et al. Brain Res, 2012 Dec 7. PMID 23059019
    4. Bmcc1s, a novel brain-isoform of Bmcc1, affects cell morphology by regulating MAP6/STOP functions. Arama J, et al. PLoS One, 2012. PMID 22523599, Free PMC Article
    5. Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas. Machida T, et al. Oncogene, 2006 Mar 23. PMID 16288218

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that odor preference and olfactory memory are impaired in Prune 2deficient mice. Knockout of Prune2 leads to a decrease in the Prune2 protein isoform Olfaxin. Levels of Olfaxin mRNA were decreased.
      Title: Odor preference and olfactory memory are impaired in Olfaxin-deficient mice.
    2. kidney-type glutaminase (KGA) as a novel partner of Bmcc1s
      Title: Bmcc1s interacts with the phosphate-activated glutaminase in the brain.
    3. We showed that Olfaxin, a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex.
      Title: Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system.
    4. This study identifies Bmcc1s as a new MAP6 interacting protein able to modulate MAP6-induced microtubule cold stability.
      Title: Bmcc1s, a novel brain-isoform of Bmcc1, affects cell morphology by regulating MAP6/STOP functions.
    5. Prune2 mRNA is predominantly expressed in the neurons of the cranial nerve motor nuclei and the motor neurons of the spinal cord
      Title: The expression and localization of Prune2 mRNA in the central nervous system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0367

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein prune homolog 2
    Names
    BNIP2 motif-containing molecule at the C-terminal region 1
    neuronal protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181348.4 → NP_851993.3  protein prune homolog 2

      See identical proteins and their annotated locations for NP_851993.3

      Status: VALIDATED

      Source sequence(s)
      AC126674, AC147026, AK039241, BC094224
      Consensus CDS
      CCDS50400.1
      UniProtKB/Swiss-Prot
      Q501M3, Q52KR3, Q6A079, Q8BW65, Q8BYM6, Q9D217
      Related
      ENSMUSP00000084977.5, ENSMUST00000087689.5
      Conserved Domains (4) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:220 → 313
      DHHA2; DHHA2 domain
      pfam12496
      Location:2782 → 2899
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2901 → 3022
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      16933033..17201322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527145.3 → XP_006527208.1  protein prune homolog 2 isoform X2

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2891
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2903 → 3040
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    2. XM_006527149.4 → XP_006527212.1  protein prune homolog 2 isoform X10

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2892
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2904 → 3041
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    3. XM_006527147.4 → XP_006527210.1  protein prune homolog 2 isoform X5

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2892
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2904 → 3041
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    4. XM_006527152.4 → XP_006527215.1  protein prune homolog 2 isoform X14

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2892
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2904 → 3041
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    5. XM_006527151.4 → XP_006527214.1  protein prune homolog 2 isoform X13

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2892
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2904 → 3041
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    6. XM_036161615.1 → XP_036017508.1  protein prune homolog 2 isoform X11

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2892
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2904 → 3035
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    7. XM_006527153.4 → XP_006527216.1  protein prune homolog 2 isoform X16

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2892
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2904 → 3035
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    8. XM_017318226.3 → XP_017173715.1  protein prune homolog 2 isoform X3

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2898
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2900 → 3037
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    9. XM_017318229.3 → XP_017173718.1  protein prune homolog 2 isoform X9

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2898
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2900 → 3037
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    10. XM_036161614.1 → XP_036017507.1  protein prune homolog 2 isoform X6

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2892
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2904 → 3041
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    11. XM_036161616.1 → XP_036017509.1  protein prune homolog 2 isoform X12

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2892
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2904 → 3035
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    12. XM_006527144.4 → XP_006527207.1  protein prune homolog 2 isoform X1

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2892
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2904 → 3041
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    13. XM_006527146.3 → XP_006527209.1  protein prune homolog 2 isoform X4

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2892
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2904 → 3041
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    14. XM_017318228.3 → XP_017173717.1  protein prune homolog 2 isoform X8

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2899
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2901 → 3038
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    15. XM_017318230.3 → XP_017173719.1  protein prune homolog 2 isoform X15

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2899
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2901 → 3038
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    16. XM_017318227.3 → XP_017173716.1  protein prune homolog 2 isoform X7

      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2899
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2901 → 3038
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    17. XM_006527154.4 → XP_006527217.1  protein prune homolog 2 isoform X17

      UniProtKB/Swiss-Prot
      Q52KR3
      Conserved Domains (3) summary
      COG1227
      Location:24 → 284
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2782 → 2899
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2901 → 3032
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    RNA

    1. XR_004940154.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q52KR3.2 GenPept UniProtKB/Swiss-Prot:Q52KR3

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