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Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 [ Mus musculus (house mouse) ]

Gene ID: 18605, updated on 2-Nov-2024

Summary

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Official Symbol: Enpp1provided by MGI
Official Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 1provided by MGI
Primary source: MGI:MGI:97370
See related: Ensembl:ENSMUSG00000037370 AllianceGenome:MGI:97370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pca; ttw; twy; M6S1; NPP1; Npps; PC-1; Ly-41; Pca-1; Pdnp1; CD203c; E-NPP1; E-NPP 1; 4833416E15Rik
Summary: This gene encodes a member of the nucleoside pyrophosphatase/phosphodiesterase family of enzymes that catalyzes the hydrolysis of pyrophosphate and phosphodiester bonds in nucleotide triphosphates and oligonucleotides, respectively, to generate nucleoside 5'-monophosphates. The encoded protein is a type II transmembrane glycoprotein that negatively regulates bone mineralization. Mice harboring a nonsense mutation in this gene, termed tiptoe walking (ttw), exhibit ectopic ossification of the spinal ligaments. The encoded protein binds to the insulin receptor, inhibits downstream signaling events and induces insulin resistance and glucose tolerance. This gene is located adjacent to a paralog on chromosome 10. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression: Biased expression in genital fat pad adult (RPKM 21.6), bladder adult (RPKM 3.9) and 5 other tissues See more
Orthologs: human all
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Genomic context

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See Enpp1 in Genome Data Viewer

Location:: 10 A4; 10 12.26 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (24513812..24588057, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (24637914..24712159, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation.
Title: TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation.
Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase 1 in mice.
Title: Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase 1 in mice.
HER2Delta16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer.
Title: HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer.
Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway.
Title: Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway.
ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway.
Title: ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway.
Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass.
Title: Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass.
ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling.
Title: ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling.
Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.
Title: Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.
Response of the ENPP1-Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice.
Title: Response of the ENPP1-Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice.
Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency.
Title: Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (7)
Spontaneous (5) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Enpp1 (e-PCR), detects polymorphism
- UniSTS:144156

C76301 (e-PCR)
- UniSTS:180016

AI428932 (e-PCR)
- UniSTS:180018

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

J02700 (e-PCR)
- UniSTS:159961

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables GTP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables UTP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables coenzyme A diphosphatase activity	TAS Traceable Author Statement more info	PubMed
enables cyclic-GMP-AMP hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclic-GMP-AMP hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cyclic-GMP-AMP hydrolase activity	ISO Inferred from Sequence Orthology more info
enables dinucleotide phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dinucleotide phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables dinucleotide phosphatase activity	ISO Inferred from Sequence Orthology more info
enables exonuclease activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside triphosphate diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside triphosphate diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables phosphodiesterase I activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphodiesterase I activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphodiesterase I activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphodiesterase I activity	ISO Inferred from Sequence Orthology more info
enables phosphoric diester hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables polysaccharide binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyrophosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in B-1 B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in artery development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in articular cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biomineral tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in bone mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in bone mineralization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in bone mineralization involved in bone maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_positive_effect cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sodium phosphate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cementum mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in cementum mineralization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cementum mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coenzyme A catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in coenzyme A catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in collagen-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diphosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endochondral bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat pad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	ISO Inferred from Sequence Orthology more info	PubMed
involved_in generation of precursor metabolites and energy	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell migration to bone marrow	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inhibition of non-skeletal tissue mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in inhibition of non-skeletal tissue mineralization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inhibition of non-skeletal tissue mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inhibition of non-skeletal tissue mineralization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in inorganic diphosphate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in inorganic diphosphate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in inorganic diphosphate transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inorganic diphosphate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inorganic diphosphate transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte activation involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ligamentous ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in magnesium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglia differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in middle ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucus secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hh target transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside triphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleoside triphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organic phosphonate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphate ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphate ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphate ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in phosphate-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in plasma cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect protein poly-ADP-ribosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to magnesium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to magnesium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to platelet-derived growth factor	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to sodium phosphate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to sodium phosphate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to vitamin B6	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
involved_in skin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tooth mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vitamin D3 metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
located_in basal dendrite	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Names: NPPase; alkaline phosphodiesterase I; lymphocyte antigen 41; nucleotide diphosphatase; nucleotide pyrophosphatase; phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein PC-1; tiptoe walking

NP_001295256.1

EC 3.1.4.1

EC 3.6.1.9

NP_001295258.1

EC 3.1.4.1

EC 3.6.1.9

NP_032839.3

EC 3.1.4.1

EC 3.6.1.9

XP_006512661.1

EC 3.1.4.1

EC 3.6.1.9

XP_006512662.1

EC 3.1.4.1

EC 3.6.1.9

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308327.1 → NP_001295256.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 1

See identical proteins and their annotated locations for NP_001295256.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC099695, AC158616, AF339910, AI428932

Consensus CDS

CCDS78802.1

UniProtKB/Swiss-Prot

P06802, Q542E9, Q924C4

UniProtKB/TrEMBL

A0A0R4J1Q7

Related

ENSMUSP00000114273.2, ENSMUST00000135846.2

Conserved Domains (4) summary

smart00201
Location:86 → 126

SO; Somatomedin B -like domains

smart00477
Location:657 → 888

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:194 → 520

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:192 → 560

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
NM_001308329.1 → NP_001295258.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses alternate splice sites in two exons in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC099695, AC158616, AI428932, AK164619

Conserved Domains (3) summary

smart00477
Location:304 → 535

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:3 → 168

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cl23718
Location:3 → 208

ALP_like; alkaline phosphatases and sulfatases
NM_008813.4 → NP_032839.3 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 2

See identical proteins and their annotated locations for NP_032839.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC099695, AC158616, AI428932, AK029600, AK164619

Consensus CDS

CCDS35870.1

UniProtKB/Swiss-Prot

P06802, Q542E9, Q924C4

UniProtKB/TrEMBL

G3X9S2

Related

ENSMUSP00000101159.2, ENSMUST00000105520.8

Conserved Domains (4) summary

smart00201
Location:86 → 126

SO; Somatomedin B -like domains

smart00477
Location:656 → 887

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:194 → 520

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:192 → 560

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

24513812..24588057 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512598.5 → XP_006512661.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1

UniProtKB/Swiss-Prot

P06802, Q542E9, Q924C4

Conserved Domains (3) summary

smart00201
Location:52 → 92

SO; Somatomedin B -like domains

smart00477
Location:623 → 854

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:160 → 486

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
XM_006512599.2 → XP_006512662.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X2

Conserved Domains (2) summary

smart00477
Location:305 → 536

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:3 → 168

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase