Mcrs1 microspherule protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mcrs1provided by MGI
Official Full Name: microspherule protein 1provided by MGI
Primary source: MGI:MGI:1858420
See related: Ensembl:ENSMUSG00000037570 AllianceGenome:MGI:1858420
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P78; MSP58; ICP22BP
Summary: Predicted to enable RNA binding activity and telomerase inhibitor activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in several cellular components, including dendrite; nuclear lumen; and perikaryon. Predicted to be part of Ino80 complex; MLL1 complex; and NSL complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human MCRS1 (microspherule protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 38.4), testis adult (RPKM 37.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.09 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (99140698..99149838, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (99242817..99251961, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.
Title: Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.
Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis.
Title: Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis.
MCRS1 is essential for epiblast development during early mouse embryogenesis.
Title: MCRS1 is essential for epiblast development during early mouse embryogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126595 (e-PCR)
- UniSTS:209153

RH136487 (e-PCR)
- UniSTS:210471

NoName (e-PCR)
- UniSTS:488683

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-quadruplex RNA binding	ISO Inferred from Sequence Orthology more info
enables G-quadruplex RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables poly(G) binding	ISO Inferred from Sequence Orthology more info
enables poly(G) binding	ISS Inferred from Sequence or Structural Similarity more info
enables poly(U) RNA binding	ISO Inferred from Sequence Orthology more info
enables poly(U) RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables telomerase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of protein localization to nucleolus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleolus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of telomere maintenance in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA strand elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ino80 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NSL complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NSL complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: microspherule protein 1

Names: 58 kDa microspherule protein; nucleolar protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164156.2 → NP_001157628.1 microspherule protein 1 isoform 2

See identical proteins and their annotated locations for NP_001157628.1

Status: VALIDATED

Source sequence(s)

AC161198

Consensus CDS

CCDS49728.1

UniProtKB/TrEMBL

Q3TJY1, Q3TYU7

Related

ENSMUSP00000131407.2, ENSMUST00000163506.3

Conserved Domains (2) summary

cd00060
Location:332 → 432

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam13325
Location:121 → 318

MCRS_N; N-terminal region of micro-spherule protein
NM_001411911.1 → NP_001398840.1 microspherule protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC161198

UniProtKB/Swiss-Prot

O35255, Q32P11, Q99L90
NM_016766.4 → NP_058046.2 microspherule protein 1 isoform 1

See identical proteins and their annotated locations for NP_058046.2

Status: VALIDATED

Source sequence(s)

AC161198

Consensus CDS

CCDS37199.1

UniProtKB/Swiss-Prot

O35255, Q32P11, Q99L90

UniProtKB/TrEMBL

Q3TYU7

Related

ENSMUSP00000043901.10, ENSMUST00000041190.17

Conserved Domains (2) summary

cd00060
Location:345 → 445

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam13325
Location:134 → 331

MCRS_N; N-terminal region of micro-spherule protein