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    Gna14 guanine nucleotide binding protein, alpha 14 [ Mus musculus (house mouse) ]

    Gene ID: 14675, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gna14provided by MGI
    Official Full Name
    guanine nucleotide binding protein, alpha 14provided by MGI
    Primary source
    MGI:MGI:95769
    See related
    Ensembl:ENSMUSG00000024697 AllianceGenome:MGI:95769
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg1i
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and phospholipase C-activating dopamine receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including axial skeleton; gut; metanephros; oocyte; and respiratory system. Orthologous to human GNA14 (G protein subunit alpha 14). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in colon adult (RPKM 20.8), adrenal adult (RPKM 12.1) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gna14 in Genome Data Viewer
    Location:
    19 A; 19 11.29 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (16413031..16590706)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (16435667..16610818)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein, alpha q polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E4270 Neighboring gene microRNA 496b Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:16447604-16447805 Neighboring gene STARR-seq mESC enhancer starr_45659 Neighboring gene STARR-seq mESC enhancer starr_45660 Neighboring gene STARR-seq mESC enhancer starr_45662 Neighboring gene predicted gene, 19312 Neighboring gene STARR-seq mESC enhancer starr_45663 Neighboring gene nuclear import 7 pseudogene Neighboring gene predicted gene, 41811 Neighboring gene STARR-seq mESC enhancer starr_45666 Neighboring gene vacuolar protein sorting 13A Neighboring gene predicted gene, 32256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:16855612-16855721 Neighboring gene STARR-seq mESC enhancer starr_45668 Neighboring gene forkhead box B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. G alpha14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue. Shindo Y, et al. Biochem Biophys Res Commun, 2008 Nov 21. PMID 18801333
    2. Tumor-Promoting Role of GNA14 in Colon Cancer Development. Park R, et al. Cancers (Basel), 2023 Sep 15. PMID 37760541, Free PMC Article
    3. Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. Wilkie TM, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1946421, Free PMC Article
    4. Promiscuous coupling of receptors to Gq class alpha subunits and effector proteins in pancreatic and submandibular gland cells. Xu X, et al. J Biol Chem, 1998 Oct 16. PMID 9765251
    5. Loss of gq/11 genes does not abolish melanopsin phototransduction. Chew KS, et al. PLoS One, 2014. PMID 24870805, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest the important roles of G alpha14 in sweet/umami taste signal transduction in the posterior region of the tongue.
      Title: G alpha14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein subunit alpha-14
    Names
    G-protein subunit alpha-14
    g alpha-14
    heterotrimeric guanine nucleotide-binding protein 1i

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008137.4 → NP_032163.3  guanine nucleotide-binding protein subunit alpha-14

      See identical proteins and their annotated locations for NP_032163.3

      Status: VALIDATED

      Source sequence(s)
      AK035320, AK085444, BY034514, CK128401
      Consensus CDS
      CCDS29685.1
      UniProtKB/Swiss-Prot
      P30677, Q8R2X9
      UniProtKB/TrEMBL
      Q8C3M7
      Related
      ENSMUSP00000025602.3, ENSMUST00000025602.4
      Conserved Domains (2) summary
      cd00066
      Location:36 → 349
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:16 → 353
      G_alpha; G protein alpha subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      16413031..16590706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161435.1 → XP_036017328.1  guanine nucleotide-binding protein subunit alpha-14 isoform X1

      Conserved Domains (1) summary
      cd00066
      Location:2 → 185
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30677.2 GenPept UniProtKB/Swiss-Prot:P30677

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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