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    Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C [ Mus musculus (house mouse) ]

    Gene ID: 394432, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ugt1a7cprovided by MGI
    Official Full Name
    UDP glucuronosyltransferase 1 family, polypeptide A7Cprovided by MGI
    Primary source
    MGI:MGI:3032636
    See related
    Ensembl:ENSMUSG00000090124 AllianceGenome:MGI:3032636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A13; A10'; UGT1A7; Ugt1a10
    Summary
    Predicted to enable several functions, including monocarboxylic acid binding activity; protein dimerization activity; and protein kinase C binding activity. Predicted to be involved in several processes, including cellular glucuronidation; coumarin catabolic process; and estrogen catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in nervous system; stomach; and urinary system. Human ortholog(s) of this gene implicated in alcoholic pancreatitis and pancreatic cancer. Orthologous to several human genes including UGT1A10 (UDP glucuronosyltransferase family 1 member A10); UGT1A7 (UDP glucuronosyltransferase family 1 member A7); and UGT1A8 (UDP glucuronosyltransferase family 1 member A8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 238.8), liver adult (RPKM 142.7) and 10 other tissues See more
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    Genomic context

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    See Ugt1a7c in Genome Data Viewer
    Location:
    1 D; 1 44.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88022723..88147724)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88095001..88220002)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene predicted gene, 38421 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene STARR-seq mESC enhancer starr_01626 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene STARR-seq mESC enhancer starr_01627 Neighboring gene STARR-seq mESC enhancer starr_01628 Neighboring gene predicted gene 15372 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6A Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene predicted gene 15371 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene predicted gene 15368 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90112870-90113171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90113610-90113910 Neighboring gene predicted gene 15376 Neighboring gene STARR-seq mESC enhancer starr_01629 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90118277-90118578 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene Holliday junction recognition protein Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene transient receptor potential cation channel, subfamily M, member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article
    2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular glucuronidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in coumarin catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrogen metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in liver development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase 1A7
    Names
    UDP glucuronosyltransferase 1 family, polypeptide A10
    UDP glycosyltransferase 1 family, polypeptide A10
    UDP-glucuronosyltransferase 1-7C
    UDP-glucuronosyltransferase 1A7C
    UDPGT 1-7C
    UGT1*7C
    UGT1-07C
    UGT1.7C
    NP_964004.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201642.4 → NP_964004.1  UDP-glucuronosyltransferase 1A7 precursor

      See identical proteins and their annotated locations for NP_964004.1

      Status: VALIDATED

      Source sequence(s)
      AC087801, AK159496, AK165465
      Consensus CDS
      CCDS15139.1
      UniProtKB/Swiss-Prot
      B2RUL6, Q6XL45, Q6ZQM8
      Related
      ENSMUSP00000058683.8, ENSMUST00000058237.14
      Conserved Domains (2) summary
      PHA03392
      Location:225 → 503
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:26 → 522
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      88022723..88147724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQM8.1 GenPept UniProtKB/Swiss-Prot:Q6ZQM8

    Gene LinkOut

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