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    SLC16A5 solute carrier family 16 member 5 [ Homo sapiens (human) ]

    Gene ID: 9121, updated on 11-Apr-2024

    Summary

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    Official Symbol
    SLC16A5provided by HGNC
    Official Full Name
    solute carrier family 16 member 5provided by HGNC
    Primary source
    HGNC:HGNC:10926
    See related
    Ensembl:ENSG00000170190 MIM:603879; AllianceGenome:HGNC:10926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT5; MCT6
    Summary
    This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
    Expression
    Broad expression in lung (RPKM 9.8), duodenum (RPKM 9.3) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC16A5 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75087385..75110149)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75978846..76001616)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73083860..73102257)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73037362-73037932 Neighboring gene potassium channel tetramerization domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 3986 Neighboring gene RNA, 7SL, cytoplasmic 573, pseudogene Neighboring gene ATP synthase peripheral stalk subunit d Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12732 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73074528-73075727 Neighboring gene tripartite motif containing 80, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73089299-73089872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73089873-73090445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73100784-73101284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73101285-73101785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73110035-73110574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12735 Neighboring gene armadillo repeat containing 7 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:73120068-73121267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12736 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73126856-73127060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8956 Neighboring gene uncharacterized LOC107985034 Neighboring gene 5', 3'-nucleotidase, cytosolic Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73143638-73144837 Neighboring gene Jupiter microtubule associated homolog 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Solute carrier family 16 member 5 downregulation and its methylation might serve as a prognostic indicator of prostate cancer. Meng X, et al. IUBMB Life, 2021 Nov. PMID 34549875
    2. Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer. Drögemöller BI, et al. JAMA Oncol, 2017 Nov 1. PMID 28448657, Free PMC Article
    3. Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions. Sugito K, et al. Pediatr Blood Cancer, 2013 Mar. PMID 22911660
    4. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). Murakami Y, et al. Drug Metab Dispos, 2005 Dec. PMID 16174808
    5. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Price NT, et al. Biochem J, 1998 Jan 15. PMID 9425115, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Solute carrier family 16 member 5 downregulation and its methylation might serve as a prognostic indicator of prostate cancer.
      Title: Solute carrier family 16 member 5 downregulation and its methylation might serve as a prognostic indicator of prostate cancer.
    2. Identify a novel association between protein-coding variation in SLC16A5 and cisplatin-induced ototoxic effects in testicular cancer patients.
      Title: Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer.
    3. We demonstrated that SLC16A5 and ZNF206 displayed altered methylation patterns in the neuroblastoma genome
      Title: Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 6
    Names
    monocarboxylate transporter 5
    solute carrier family 16 (monocarboxylate transporter), member 5
    solute carrier family 16 (monocarboxylic acid transporters), member 5
    solute carrier family 16, member 5 (monocarboxylic acid transporter 6)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271765.2 → NP_001258694.1  monocarboxylate transporter 6

      See identical proteins and their annotated locations for NP_001258694.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK000416, AW452009
      Consensus CDS
      CCDS11713.1
      UniProtKB/Swiss-Prot
      B4E288, O15375
      UniProtKB/TrEMBL
      B3KS01
      Related
      ENSP00000463434.1, ENST00000580123.5
      Conserved Domains (1) summary
      TIGR00892
      Location:1 → 453
      2A0113; monocarboxylate transporter 1

    2. NM_001369668.1 → NP_001356597.1  monocarboxylate transporter 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC111186, BC033611, U59299
      Consensus CDS
      CCDS11713.1
      UniProtKB/Swiss-Prot
      B4E288, O15375
      UniProtKB/TrEMBL
      B3KS01
      Related
      ENSP00000390564.2, ENST00000450736.6
      Conserved Domains (1) summary
      TIGR00892
      Location:1 → 453
      2A0113; monocarboxylate transporter 1

    3. NM_004695.4 → NP_004686.1  monocarboxylate transporter 6

      See identical proteins and their annotated locations for NP_004686.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK000416, AW452009, BC009684, BC033611, BI820515
      Consensus CDS
      CCDS11713.1
      UniProtKB/Swiss-Prot
      B4E288, O15375
      UniProtKB/TrEMBL
      B3KS01
      Related
      ENSP00000330141.4, ENST00000329783.9
      Conserved Domains (1) summary
      TIGR00892
      Location:1 → 453
      2A0113; monocarboxylate transporter 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      75087385..75110149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437035.1 → XP_047292991.1  monocarboxylate transporter 6 isoform X10

    2. XM_047437027.1 → XP_047292983.1  monocarboxylate transporter 6 isoform X4

    3. XM_047437028.1 → XP_047292984.1  monocarboxylate transporter 6 isoform X4

    4. XM_047437031.1 → XP_047292987.1  monocarboxylate transporter 6 isoform X4

    5. XM_047437026.1 → XP_047292982.1  monocarboxylate transporter 6 isoform X4

    6. XM_047437029.1 → XP_047292985.1  monocarboxylate transporter 6 isoform X4

    7. XM_047437024.1 → XP_047292980.1  monocarboxylate transporter 6 isoform X4

    8. XM_047437025.1 → XP_047292981.1  monocarboxylate transporter 6 isoform X4

    9. XM_047437033.1 → XP_047292989.1  monocarboxylate transporter 6 isoform X7

    10. XM_047437022.1 → XP_047292978.1  monocarboxylate transporter 6 isoform X2

    11. XM_047437030.1 → XP_047292986.1  monocarboxylate transporter 6 isoform X4

    12. XM_047437021.1 → XP_047292977.1  monocarboxylate transporter 6 isoform X1

    13. XM_047437023.1 → XP_047292979.1  monocarboxylate transporter 6 isoform X3

    14. XM_005257790.2 → XP_005257847.1  monocarboxylate transporter 6 isoform X6

      UniProtKB/TrEMBL
      B3KS01
      Related
      ENSP00000440212.2, ENST00000538213.6
      Conserved Domains (2) summary
      cd06174
      Location:54 → 452
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:41 → 493
      2A0113; monocarboxylate transporter 1

    15. XM_011525462.2 → XP_011523764.1  monocarboxylate transporter 6 isoform X8

      Conserved Domains (2) summary
      cd06174
      Location:72 → 419
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:84 → 419
      MFS_1; Major Facilitator Superfamily

    16. XM_047437032.1 → XP_047292988.1  monocarboxylate transporter 6 isoform X5

    17. XM_047437034.1 → XP_047292990.1  monocarboxylate transporter 6 isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      75978846..76001616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317756.1 → XP_054173731.1  monocarboxylate transporter 6 isoform X10

    2. XM_054317745.1 → XP_054173720.1  monocarboxylate transporter 6 isoform X4

    3. XM_054317747.1 → XP_054173722.1  monocarboxylate transporter 6 isoform X4

    4. XM_054317750.1 → XP_054173725.1  monocarboxylate transporter 6 isoform X4

    5. XM_054317743.1 → XP_054173718.1  monocarboxylate transporter 6 isoform X4

    6. XM_054317744.1 → XP_054173719.1  monocarboxylate transporter 6 isoform X4

    7. XM_054317746.1 → XP_054173721.1  monocarboxylate transporter 6 isoform X4

    8. XM_054317748.1 → XP_054173723.1  monocarboxylate transporter 6 isoform X4

    9. XM_054317753.1 → XP_054173728.1  monocarboxylate transporter 6 isoform X7

    10. XM_054317741.1 → XP_054173716.1  monocarboxylate transporter 6 isoform X2

    11. XM_054317749.1 → XP_054173724.1  monocarboxylate transporter 6 isoform X4

    12. XM_054317742.1 → XP_054173717.1  monocarboxylate transporter 6 isoform X3

    13. XM_054317740.1 → XP_054173715.1  monocarboxylate transporter 6 isoform X1

    14. XM_054317752.1 → XP_054173727.1  monocarboxylate transporter 6 isoform X6

    15. XM_054317754.1 → XP_054173729.1  monocarboxylate transporter 6 isoform X8

    16. XM_054317751.1 → XP_054173726.1  monocarboxylate transporter 6 isoform X5

    17. XM_054317755.1 → XP_054173730.1  monocarboxylate transporter 6 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15375.1 GenPept UniProtKB/Swiss-Prot:O15375

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