Adam32 a disintegrin and metallopeptidase domain 32 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam32provided by MGI
Official Full Name: a disintegrin and metallopeptidase domain 32provided by MGI
Primary source: MGI:MGI:2653822
See related: Ensembl:ENSMUSG00000037437 AllianceGenome:MGI:2653822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene was found to be expressed predominantly in the pachytene spermatocytes, where the processed protein is localized to the sperm surface. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Expression: Restricted expression toward testis adult (RPKM 110.6) See more
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Genomic context

Location:: 8 A2; 8 13.65 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (25326159..25438933, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (24836143..24948918, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Normal fertility in male mice lacking ADAM32 with testis-specific expression.
Title: Normal fertility in male mice lacking ADAM32 with testis-specific expression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 32

Names: a disintegrin and metalloprotease domain 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293693.2 → NP_001280622.1 disintegrin and metalloproteinase domain-containing protein 32 isoform 2 precursor

See identical proteins and their annotated locations for NP_001280622.1

Status: VALIDATED

Source sequence(s)

AC117643, AC156553

Consensus CDS

CCDS80867.1

UniProtKB/Swiss-Prot

Q8K410

Related

ENSMUSP00000113076.2, ENSMUST00000119720.8

Conserved Domains (5) summary

smart00608
Location:483 → 622

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:188 → 382

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:400 → 479

Disintegrin; Disintegrin

pfam01421
Location:188 → 384

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:40 → 144

Pep_M12B_propep; Reprolysin family propeptide
NM_001426375.1 → NP_001413304.1 disintegrin and metalloproteinase domain-containing protein 32 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC117643, AC156553
NM_153397.3 → NP_700446.2 disintegrin and metalloproteinase domain-containing protein 32 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_700446.2

Status: VALIDATED

Source sequence(s)

AC117643, AC156553

Consensus CDS

CCDS40300.2

UniProtKB/Swiss-Prot

Q6P901, Q8BJ80, Q8K410

Related

ENSMUSP00000113627.3, ENSMUST00000121438.9

Conserved Domains (5) summary

smart00608
Location:483 → 622

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:188 → 382

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:400 → 479

Disintegrin; Disintegrin

pfam01421
Location:188 → 384

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:40 → 144

Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

25326159..25438933 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509162.3 → XP_006509225.1 disintegrin and metalloproteinase domain-containing protein 32 isoform X1

Conserved Domains (4) summary

smart00608
Location:483 → 622

ACR; ADAM Cysteine-Rich Domain

pfam00200
Location:400 → 478

Disintegrin

pfam01421
Location:188 → 384

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:33 → 145

Pep_M12B_propep; Reprolysin family propeptide