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    Rbsn rabenosyn, RAB effector [ Mus musculus (house mouse) ]

    Gene ID: 78287, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Rbsnprovided by MGI
    Official Full Name
    rabenosyn, RAB effectorprovided by MGI
    Primary source
    MGI:MGI:1925537
    See related
    Ensembl:ENSMUSG00000014550 AllianceGenome:MGI:1925537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfyve20; 5330426D11Rik
    Summary
    Enables small GTPase binding activity. Predicted to be involved in Golgi to lysosome transport; early endosome to Golgi transport; and regulation of Golgi organization. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in central nervous system; genitourinary system; and retina outer nuclear layer. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.2), cerebellum adult (RPKM 6.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbsn in Genome Data Viewer
    Location:
    6 D1; 6 41.03 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (92163693..92191874, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (92186712..92214894, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2, group C, member 2 Neighboring gene predicted gene, 46967 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene STARR-seq mESC enhancer starr_16664 Neighboring gene thyrotropin releasing hormone Neighboring gene predicted gene, 30688 Neighboring gene predicted gene 44803

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Mishra A, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534488, Free PMC Article
    2. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
    3. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in early endosome to Golgi transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rabenosyn-5
    Names
    FYVE finger-containing Rab5 effector protein rabenosyn-5
    RAB effector RBSN
    zinc finger FYVE domain-containing protein 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030081.3 → NP_084357.2  rabenosyn-5

      See identical proteins and their annotated locations for NP_084357.2

      Status: VALIDATED

      Source sequence(s)
      BC049106, BY149674
      Consensus CDS
      CCDS20374.1
      UniProtKB/Swiss-Prot
      Q80Y56, Q8K0L6, Q9CTW0
      Related
      ENSMUSP00000014694.9, ENSMUST00000014694.11
      Conserved Domains (3) summary
      cd15716
      Location:150 → 261
      FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
      pfam11464
      Location:460 → 498
      Rbsn; Rabenosyn Rab binding domain
      pfam16601
      Location:548 → 726
      NPF; Rabosyn-5 repeating NPF sequence-motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      92163693..92191874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506769.5 → XP_006506832.1  rabenosyn-5 isoform X2

      Conserved Domains (3) summary
      cd15716
      Location:62 → 173
      FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
      pfam11464
      Location:372 → 408
      Rbsn; Rabenosyn Rab binding domain
      pfam16601
      Location:460 → 638
      NPF; Rabosyn-5 repeating NPF sequence-motif

    2. XM_036152400.1 → XP_036008293.1  rabenosyn-5 isoform X1

      Conserved Domains (3) summary
      cd15716
      Location:120 → 231
      FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
      pfam11464
      Location:430 → 468
      Rbsn; Rabenosyn Rab binding domain
      pfam16601
      Location:518 → 696
      NPF; Rabosyn-5 repeating NPF sequence-motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Y56.1 GenPept UniProtKB/Swiss-Prot:Q80Y56

    Gene LinkOut

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