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    Mlf1 myeloid leukemia factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 17349, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mlf1provided by MGI
    Official Full Name
    myeloid leukemia factor 1provided by MGI
    Primary source
    MGI:MGI:1341819
    See related
    Ensembl:ENSMUSG00000048416 AllianceGenome:MGI:1341819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HLS7
    Summary
    Enables DNA binding activity. Involved in DNA-templated transcription and myeloid progenitor cell differentiation. Located in several cellular components, including ciliary basal body; motile cilium; and non-motile cilium. Is active in ciliary base. Is expressed in several structures, including brain; gonad; immune system; lung; and nasal cavity respiratory epithelium. Orthologous to human MLF1 (myeloid leukemia factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 137.0) and heart adult (RPKM 22.3) See more
    Orthologs
    human all
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    Genomic context

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    See Mlf1 in Genome Data Viewer
    Location:
    3 E1; 3 30.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (67281430..67307333)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (67374097..67400000)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07883 Neighboring gene arginine/serine-rich coiled-coil 1 Neighboring gene predicted gene, 54201 Neighboring gene predicted gene, 22295 Neighboring gene STARR-seq mESC enhancer starr_07884 Neighboring gene STARR-positive B cell enhancer ABC_E6060 Neighboring gene STARR-positive B cell enhancer mm9_chr3:67177807-67178108 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene retinoic acid receptor responder (tazarotene induced) 1 Neighboring gene latexin Neighboring gene predicted gene, 40067

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1. Williams JH, et al. EMBO J, 1999 Oct 15. PMID 10523300, Free PMC Article
    2. Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice. Li ZF, et al. J Neurol Sci, 2008 Jan 15. PMID 17854834
    3. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Yoneda-Kato N, et al. Oncogene, 1996 Jan 18. PMID 8570204
    4. Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation. Yoneda-Kato N, et al. Mol Cell Biol, 2008 Jan. PMID 17967869, Free PMC Article
    5. Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3. Sun Y, et al. J Physiol Biochem, 2015 Dec. PMID 26563351

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data indicate that MLF1 serves as a proapoptotic antagonist that interacts with the HAX1/HtrA2-OMI/PARL (HOP) mitochondrial complex to modulate cell survival.
      Title: MLF1 is a proapoptotic antagonist of HOP complex-mediated survival.
    2. Ectopically expressed MLF1 could be responsible for the pathological apoptosis in early myelodysplastic syndrome (MDS) patients.
      Title: Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3.
    3. shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation
      Title: Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation.
    4. Mlf1 translocates between nucleus and cytoplasm, associates with a novel hnRNP, and influences gene expression
      Title: Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in myeloid progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_positive_effect regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myeloid leukemia factor 1
    Names
    hematopoietic lineage switch 7
    myelodysplasia-myeloid leukemia factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039543.2 → NP_001034632.1  myeloid leukemia factor 1 isoform a

      See identical proteins and their annotated locations for NP_001034632.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK133448, BC027526
      Consensus CDS
      CCDS17395.1
      UniProtKB/TrEMBL
      Q8JZS2
      Related
      ENSMUSP00000058596.9, ENSMUST00000061322.10
      Conserved Domains (1) summary
      pfam10248
      Location:27 → 217
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    2. NM_010801.3 → NP_034931.2  myeloid leukemia factor 1 isoform b

      See identical proteins and their annotated locations for NP_034931.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AK133448, BC027526
      Consensus CDS
      CCDS17396.1
      UniProtKB/Swiss-Prot
      O70217, Q9QWV4
      UniProtKB/TrEMBL
      Q3V042
      Related
      ENSMUSP00000077072.6, ENSMUST00000077916.12
      Conserved Domains (1) summary
      pfam10248
      Location:27 → 202
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      67281430..67307333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QWV4.1 GenPept UniProtKB/Swiss-Prot:Q9QWV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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