U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Arrdc2 arrestin domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 70807, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Arrdc2provided by MGI
    Official Full Name
    arrestin domain containing 2provided by MGI
    Primary source
    MGI:MGI:1918057
    See related
    Ensembl:ENSMUSG00000002910 AllianceGenome:MGI:1918057
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ilad1; 4632416I05Rik
    Summary
    Predicted to be involved in protein transport. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and plasma membrane. Is expressed in bone; metanephros; and testis. Orthologous to human ARRDC2 (arrestin domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 30.6), ovary adult (RPKM 22.5) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Arrdc2 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71287773..71293173, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70835129..70839720, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene microRNA 7240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73330531-73330714 Neighboring gene interleukin 12 receptor, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E133 Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E3780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73389712-73389895 Neighboring gene coiled-coil domain containing 124

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The mechanosensitive gene arrestin domain containing 2 regulates myotube diameter with direct implications for disuse atrophy with aging. Laskin GR, et al. Am J Physiol Cell Physiol, 2024 Mar 1. PMID 38314723,
    2. Molecular genetic responses to lysergic acid diethylamide include transcriptional activation of MAP kinase phosphatase-1, C/EBP-beta and ILAD-1, a novel gene with homology to arrestins. Nichols CD, et al. J Neurochem, 2004 Aug. PMID 15255935
    3. The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange. Patwari P, et al. J Biol Chem, 2006 Aug 4. PMID 16766796, Free PMC Article
    4. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. Nott A, et al. Nat Neurosci, 2016 Nov. PMID 27428650, Free PMC Article
    5. Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition. Wu Y, et al. Front Cell Dev Biol, 2020. PMID 33634103, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mechanosensitive gene arrestin domain containing 2 regulates myotube diameter with direct implications for disuse atrophy with aging.
      Title: The mechanosensitive gene arrestin domain containing 2 regulates myotube diameter with direct implications for disuse atrophy with aging.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    arrestin domain-containing protein 2
    Names
    induced by lysergic acid diethylamide-1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027560.1 → NP_081836.1  arrestin domain-containing protein 2

      See identical proteins and their annotated locations for NP_081836.1

      Status: PROVISIONAL

      Source sequence(s)
      AK014582
      Consensus CDS
      CCDS40376.1
      UniProtKB/Swiss-Prot
      Q3UVK8, Q3UXC6, Q9D668
      UniProtKB/TrEMBL
      Q0GJK2
      Related
      ENSMUSP00000002989.10, ENSMUST00000002989.11
      Conserved Domains (2) summary
      smart01017
      Location:180 → 307
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:9 → 158
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71287773..71293173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154287.1 → XP_036010180.1  arrestin domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      smart01017
      Location:28 → 155
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain

    2. XM_017312963.3 → XP_017168452.1  arrestin domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      smart01017
      Location:28 → 155
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain

    RNA

    1. XR_379046.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D668.1 GenPept UniProtKB/Swiss-Prot:Q9D668

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools