Noc3l NOC3 like DNA replication regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Noc3lprovided by MGI
Official Full Name: NOC3 like DNA replication regulatorprovided by MGI
Primary source: MGI:MGI:1932610
See related: Ensembl:ENSMUSG00000024999 AllianceGenome:MGI:1932610
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fad24
Summary: Predicted to enable chromatin binding activity. Acts upstream of or within fat cell differentiation. Located in nuclear speck and nucleolus. Is expressed in several structures, including central nervous system; ganglia; olfactory epithelium; thymus; and urinary system. Orthologous to human NOC3L (NOC3 like DNA replication regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.0), limb E14.5 (RPKM 4.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 33.42 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (38776565..38808754, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (38788121..38820310, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

fad24 may have an important role in the S phase re-entry of quiescent C2C12 cells through the regulation of p27(Kip1) at the protein level
Title: Fad24, a Positive Regulator of Adipogenesis, Is Required for S Phase Re-entry of C2C12 Myoblasts Arrested in G0 Phase and Involved in p27(Kip1) Expression at the Protein Level.
It contributes not only to adipogenesis but also to other physiological events like pre-implantation in embryonic developments.
Title: [Molecular Mechanisms of Early-stage Adipocyte Differentiation and Multi-functional Roles of Newly Isolated Adipogenic Factors].
fad24 is essential for pre-implantation in embryonic development, particularly for the progression to the blastocyst stage
Title: Targeted disruption of fad24, a regulator of adipogenesis, causes pre-implantation embryonic lethality due to the growth defect at the blastocyst stage.
fad24 plays positive roles in the proliferation of pre-confluent cells as well as adipogenesis
Title: FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation.
Taken together, these results reveal a novel role for fad24 in the repression of NF-kappaB activity and H-ras-mediated transformation.
Title: FAD24, a regulator of adipogenesis and DNA replication, inhibits H-RAS-mediated transformation by repressing NF-kappaB activity.
FAD24 controls DNA replication by recruiting HBO1 to origins of DNA replication and is required for MCE during adipocyte differentiation.
Title: FAD24 acts in concert with histone acetyltransferase HBO1 to promote adipogenesis by controlling DNA replication.
Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation
Title: Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF233884 (e-PCR), detects polymorphism
- UniSTS:265412

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleolar complex protein 3 homolog

Names: NOC3 protein homolog; NOC3-like protein; factor for adipocyte differentiation 24; nucleolar complex associated 3 homolog; nucleolar complex-associated protein 3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021315.2 → NP_067290.2 nucleolar complex protein 3 homolog

See identical proteins and their annotated locations for NP_067290.2

Status: VALIDATED

Source sequence(s)

AC101775, AC111023, AC158131

Consensus CDS

CCDS37974.1

UniProtKB/Swiss-Prot

E9QQ46, Q8VI84, Q9JKM3

Related

ENSMUSP00000025963.8, ENSMUST00000025963.8

Conserved Domains (3) summary

COG5117
Location:113 → 712

NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]

pfam03914
Location:554 → 707

CBF; CBF/Mak21 family

pfam07540
Location:213 → 307

NOC3p; Nucleolar complex-associated protein