Habp4 hyaluronic acid binding protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Habp4provided by MGI
Official Full Name: hyaluronic acid binding protein 4provided by MGI
Primary source: MGI:MGI:1891713
See related: Ensembl:ENSMUSG00000021476 AllianceGenome:MGI:1891713
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933413D03Rik; 4933428J01Rik
Summary: Predicted to enable several functions, including SUMO binding activity; hyaluronic acid binding activity; and translation elongation factor binding activity. Predicted to be involved in PML body organization; cellular response to mechanical stimulus; and regulation of gene expression. Predicted to act upstream of or within hyaluronan metabolic process. Located in cytoplasm. Is active in synapse. Is expressed in central nervous system; ovary; retina; and white fat. Orthologous to human HABP4 (hyaluronan binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 67.5), cortex adult (RPKM 46.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B3; 13 33.26 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (64309680..64334351)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (64161866..64186537)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables SUMO binding	ISO Inferred from Sequence Orthology more info
enables SUMO binding	ISS Inferred from Sequence or Structural Similarity more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info	PubMed
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation elongation factor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in PML body organization	ISO Inferred from Sequence Orthology more info
involved_in PML body organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hyaluronan metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA binding	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome hibernation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in Cajal body	ISS Inferred from Sequence or Structural Similarity more info
located_in Gemini of coiled bodies	ISO Inferred from Sequence Orthology more info
located_in Gemini of coiled bodies	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info
located_in sarcomere	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasm	IEA Inferred from Electronic Annotation more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: intracellular hyaluronan-binding protein 4

Names: IHABP-4; IHABP4; hyaluronic acid-binding protein 4 (intracellular); intracellular hyaluronan-binding protein p57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019986.3 → NP_064370.2 intracellular hyaluronan-binding protein 4

Status: VALIDATED

Source sequence(s)

AK016800, AK146525, CD776978

Consensus CDS

CCDS36702.1

UniProtKB/Swiss-Prot

Q3UNH8, Q9D450, Q9JKS5

UniProtKB/TrEMBL

E9QKB2

Related

ENSMUSP00000021929.9, ENSMUST00000021929.10

Conserved Domains (2) summary

pfam04774
Location:212 → 315

HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

pfam16174
Location:16 → 131

IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal