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    Ints6l integrator complex subunit 6 like [ Mus musculus (house mouse) ]

    Gene ID: 236790, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ints6lprovided by MGI
    Official Full Name
    integrator complex subunit 6 likeprovided by MGI
    Primary source
    MGI:MGI:2442593
    See related
    Ensembl:ENSMUSG00000035967 AllianceGenome:MGI:2442593
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx26b; D130066O12; 4930535D10Rik; 6330505F04Rik
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. Orthologous to human INTS6L (integrator complex subunit 6 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 32.1), liver E14.5 (RPKM 25.2) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ints6l in Genome Data Viewer
    Location:
    X A5; X 30.06 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (55500180..55553201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (56454825..56507843)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 10 like 2A Neighboring gene predicted gene 2155 Neighboring gene STARR-positive B cell enhancer ABC_E8761 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene cancer/testis antigen 45 Neighboring gene microRNA 5116 Neighboring gene membrane magnesium transporter 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 6-like
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
    protein DDX26B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403599.1 → NP_001390528.1  integrator complex subunit 6-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC048362

    2. NM_001403600.1 → NP_001390529.1  integrator complex subunit 6-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC048362

    3. NM_001403601.1 → NP_001390530.1  integrator complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC048362

    4. NM_001403602.1 → NP_001390531.1  integrator complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC048362

    5. NM_001403604.1 → NP_001390533.1  integrator complex subunit 6-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC048362

    6. NM_001403605.1 → NP_001390534.1  integrator complex subunit 6-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC048362

    7. NM_001403606.1 → NP_001390535.1  integrator complex subunit 6-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC048362

    8. NM_172779.5 → NP_766367.1  integrator complex subunit 6-like isoform 2

      See identical proteins and their annotated locations for NP_766367.1

      Status: VALIDATED

      Source sequence(s)
      AC048362
      Consensus CDS
      CCDS30145.1
      UniProtKB/Swiss-Prot
      Q8BND4
      Related
      ENSMUSP00000035379.3, ENSMUST00000039374.9
      Conserved Domains (2) summary
      pfam13519
      Location:4 → 103
      VWA_2; von Willebrand factor type A domain
      pfam15300
      Location:777 → 838
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      55500180..55553201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161922.1 → XP_036017815.1  integrator complex subunit 6-like isoform X6

      Conserved Domains (1) summary
      pfam13519
      Location:4 → 103
      VWA_2; von Willebrand factor type A domain

    2. XM_036161918.1 → XP_036017811.1  integrator complex subunit 6-like isoform X2

      UniProtKB/Swiss-Prot
      Q8BND4
      Related
      ENSMUSP00000139507.2, ENSMUST00000186445.7
      Conserved Domains (2) summary
      pfam13519
      Location:4 → 103
      VWA_2; von Willebrand factor type A domain
      pfam15300
      Location:777 → 838
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    3. XM_036161919.1 → XP_036017812.1  integrator complex subunit 6-like isoform X3

      Conserved Domains (2) summary
      pfam13519
      Location:4 → 103
      VWA_2; von Willebrand factor type A domain
      pfam15300
      Location:771 → 832
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    4. XM_036161921.1 → XP_036017814.1  integrator complex subunit 6-like isoform X5

      Conserved Domains (1) summary
      pfam15300
      Location:378 → 439
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    5. XM_036161920.1 → XP_036017813.1  integrator complex subunit 6-like isoform X4

      UniProtKB/TrEMBL
      F6WNG1
      Related
      ENSMUSP00000118865.2, ENSMUST00000143142.8
      Conserved Domains (1) summary
      pfam15300
      Location:564 → 625
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RNA

    1. XR_003953008.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BND4.1 GenPept UniProtKB/Swiss-Prot:Q8BND4

    Gene LinkOut

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