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    TC2N tandem C2 domains, nuclear [ Homo sapiens (human) ]

    Gene ID: 123036, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TC2Nprovided by HGNC
    Official Full Name
    tandem C2 domains, nuclearprovided by HGNC
    Primary source
    HGNC:HGNC:19859
    See related
    Ensembl:ENSG00000165929 MIM:619305; AllianceGenome:HGNC:19859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C2CD1; TAC2N; Tac2-N; MTAC2D1; C14orf47
    Summary
    Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in gall bladder (RPKM 19.6), stomach (RPKM 15.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TC2N in Genome Data Viewer
    Location:
    14q32.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (91779746..91867536, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (86009200..86097026, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (92246090..92333880, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene pyruvate dehydrogenase kinase 3 pseudogene Neighboring gene small nucleolar RNA U3 Neighboring gene MPRA-validated peak2233 silencer Neighboring gene uncharacterized LOC124903362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8925 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:92363455-92363968 Neighboring gene fibulin 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:92392675-92393174 Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene prothymosin alpha pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers. Li H, et al. Front Immunol, 2021. PMID 34925334, Free PMC Article
    2. Tac2-N acts as a novel oncogene and promotes tumor metastasis via activation of NF-κB signaling in lung cancer. Hao X, et al. J Exp Clin Cancer Res, 2019 Aug 30. PMID 31466523, Free PMC Article
    3. TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer. Hao XL, et al. Cell Death Differ, 2019 Jul. PMID 30254375, Free PMC Article
    4. Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. Fukuda M, et al. FEBS Lett, 2001 Aug 17. PMID 11526914
    5. Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels. Morange PE, et al. J Thromb Haemost, 2011 Jan. PMID 21029358

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
      Title: TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
    2. TC2N Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Targeting the Wnt/beta-Catenin Signaling Pathway.
      Title: TC2N Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Targeting the Wnt/β-Catenin Signaling Pathway.
    3. TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers.
      Title: TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers.
    4. The TC2N attenuates p53 signaling pathway through inhibiting Cdk5-induced phosphorylation of p53 via inducing Cdk5 degradation or disrupting the interaction between Cdk5 and p53.
      Title: TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer.
    5. Study provided proof of principle to show that Tac2-N serves as a novel oncogene gene and plays an important role in the progression and metastasis of lung cancer.
      Title: Tac2-N acts as a novel oncogene and promotes tumor metastasis via activation of NF-κB signaling in lung cancer.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tandem C2 domains, nuclear (TC2N) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36557, DKFZp779J0742

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tandem C2 domains nuclear protein
    Names
    C2 calcium-dependent domain containing 1
    membrane targeting (tandem) C2 domain containing 1
    tandem C2 protein in nucleus

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128595.3 → NP_001122067.2  tandem C2 domains nuclear protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AL121839
      Consensus CDS
      CCDS9897.1
      UniProtKB/Swiss-Prot
      Q8N9U0
      Related
      ENSP00000353802.5, ENST00000360594.9
      Conserved Domains (2) summary
      cd08684
      Location:240 → 342
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:353 → 487
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    2. NM_001128596.3 → NP_001122068.2  tandem C2 domains nuclear protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AL121839, AL590328
      Consensus CDS
      CCDS9897.1
      UniProtKB/Swiss-Prot
      Q8N9U0
      Related
      ENSP00000387882.2, ENST00000435962.7
      Conserved Domains (2) summary
      cd08684
      Location:240 → 342
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:353 → 487
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    3. NM_001289134.2 → NP_001276063.2  tandem C2 domains nuclear protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL121839
      Consensus CDS
      CCDS73679.1
      Related
      ENSP00000451317.1, ENST00000556018.5
      Conserved Domains (2) summary
      cd08692
      Location:289 → 423
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cl14603
      Location:240 → 285
      C2; C2 domain

    4. NM_152332.6 → NP_689545.2  tandem C2 domains nuclear protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AL121839
      Consensus CDS
      CCDS9897.1
      UniProtKB/Swiss-Prot
      Q8N9U0
      Related
      ENSP00000343199.5, ENST00000340892.9
      Conserved Domains (2) summary
      cd08684
      Location:240 → 342
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:353 → 487
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      91779746..91867536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187598.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      247541..304250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      86009200..86097026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N9U0.2 GenPept UniProtKB/Swiss-Prot:Q8N9U0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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