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    TAS2R46 taste 2 receptor member 46 [ Homo sapiens (human) ]

    Gene ID: 259292, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TAS2R46provided by HGNC
    Official Full Name
    taste 2 receptor member 46provided by HGNC
    Primary source
    HGNC:HGNC:18877
    See related
    Ensembl:ENSG00000226761 MIM:612774; AllianceGenome:HGNC:18877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2R46; T2R54
    Summary
    TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
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    Genomic context

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    See TAS2R46 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (11061365..11062294, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10936559..10937488, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11213964..11214893, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene taste 2 receptor member 31 Neighboring gene taste 2 receptor member 63 pseudogene Neighboring gene MPRA-validated peak1573 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:11223850-11224544 Neighboring gene taste 2 receptor member 64 pseudogene Neighboring gene taste 2 receptor member 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Xu W, et al. Science, 2022 Sep 16. PMID 36108005
    2. Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca(2+)-shuttling event. Talmon M, et al. J Biol Chem, 2019 Aug 16. PMID 31248983, Free PMC Article
    3. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression. Lund TC, et al. PLoS One, 2013. PMID 23520545, Free PMC Article
    4. Genotyping Analysis of Bitter-Taste Receptor Genes TAS2R38 and TAS2R46 in Japanese Patients with Gastrointestinal Cancers. Yamaki M, et al. J Nutr Sci Vitaminol (Tokyo), 2017. PMID 28552880
    5. Association study of the three functional polymorphisms (TAS2R46G>A, OR4C16G>A, and OR4X1A>T) with recurrent pregnancy loss. Ryu CS, et al. Genes Genomics, 2019 Jan. PMID 30203366

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
      Title: Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
    2. Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca(2+)-shuttling event.
      Title: Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca(2+)-shuttling event.
    3. TAS2R46G>A rs2708381 is not associated with recurrent pregnancy loss in Korean women.
      Title: Association study of the three functional polymorphisms (TAS2R46G>A, OR4C16G>A, and OR4X1A>T) with recurrent pregnancy loss.
    4. Gastrointestinal cancer risk is not associated with any TAS2R46 genotypes since there were no significant differences in genotype frequencies between cancer patients and controls
      Title: Genotyping Analysis of Bitter-Taste Receptor Genes TAS2R38 and TAS2R46 in Japanese Patients with Gastrointestinal Cancers.
    5. MSC express the bitter taste receptor, TAS2R46, a protein more typically localized to the taste bud. Expression was also confirmed in VSMCs.
      Title: Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC134865

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bitter taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bitter taste receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    taste receptor type 2 member 46
    Names
    taste receptor type 2 member 54
    taste receptor, type 2, member 46

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426846.1 → NP_001413775.1  taste receptor type 2 member 46 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents an alternate 'A' allele of the SNP rs2708381, which results in a premature stop codon in T2T-CHM13 genome assembly. The resulting protein lacks one transmembrane domain, and is shorter than isoform 1.
      Source sequence(s)
      CP068266
      UniProtKB/TrEMBL
      A0A0J9YY42

    2. NM_176887.2 → NP_795368.2  taste receptor type 2 member 46 isoform 1

      See identical proteins and their annotated locations for NP_795368.2

      Status: VALIDATED

      Source sequence(s)
      AC018630
      Consensus CDS
      CCDS53748.1
      UniProtKB/Swiss-Prot
      P59540, P59548, Q645X6
      UniProtKB/TrEMBL
      Q50KH0
      Related
      ENSP00000436450.1, ENST00000533467.1
      Conserved Domains (1) summary
      pfam05296
      Location:1 → 298
      TAS2R; Taste receptor protein (TAS2R)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      11061365..11062294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      260071..261000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      262229..263158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10936559..10937488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59540.2 GenPept UniProtKB/Swiss-Prot:P59540

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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