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    herpud1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 565499, updated on 2-Nov-2024

    Summary

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    Official Symbol
    herpud1provided by ZNC
    Official Full Name
    homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050913-47
    See related
    Ensembl:ENSDARG00000024314 AllianceGenome:ZFIN:ZDB-GENE-050913-47
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:114134
    Summary
    Predicted to enable transmembrane transporter binding activity. Predicted to be involved in several processes, including endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum unfolded protein response; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in telencephalon. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See herpud1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (17600729..17608578)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (17611573..17619512)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene microRNA 138 Neighboring gene solute carrier family 12 member 3 Neighboring gene cholesteryl ester transfer protein, plasma Neighboring gene NLR family, CARD domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Induction of endoplasmic reticulum stress markers in an acromegaly model. Elbialy A, et al. J Cell Biochem, 2022 Sep. PMID 35734917
    2. A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver. Ramdas Nair A, et al. Genomics, 2022 Jan. PMID 34863900
    3. Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90. Pfeiffer J, et al. Dev Biol, 2018 Apr 15. PMID 29477339
    4. Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Aanes H, et al. Genome Res, 2011 Aug. PMID 21555364, Free PMC Article
    5. Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Gu Q, et al. J Appl Toxicol, 2021 Feb. PMID 32691447

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114134

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025537.1 → NP_001020708.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

      See identical proteins and their annotated locations for NP_001020708.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097190
      UniProtKB/TrEMBL
      Q4V8U9
      Related
      ENSDARP00000126535.1, ENSDART00000151934.3
      Conserved Domains (1) summary
      cl00155
      Location:12 → 92
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      17600729..17608578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159120.5 → XP_005159177.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A286YAA4, A0A8M2B617
      Related
      ENSDARP00000144135.1, ENSDART00000175258.2
      Conserved Domains (1) summary
      cl00155
      Location:12 → 92
      UBQ; Ubiquitin-like proteins

    2. XM_005159121.5 → XP_005159178.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A8M2B5Q0
      Conserved Domains (1) summary
      cl00155
      Location:12 → 92
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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