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    CLEC1B C-type lectin domain family 1 member B [ Homo sapiens (human) ]

    Gene ID: 51266, updated on 3-Nov-2024

    Summary

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    Official Symbol
    CLEC1Bprovided by HGNC
    Official Full Name
    C-type lectin domain family 1 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:24356
    See related
    Ensembl:ENSG00000165682 MIM:606783; AllianceGenome:HGNC:24356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik
    Summary
    Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
    Expression
    Biased expression in liver (RPKM 4.2), bone marrow (RPKM 0.6) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See CLEC1B in Genome Data Viewer
    Location:
    12p13.31-p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (9993075..10001899, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (9879239..9888052, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10145674..10154498, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2470 Neighboring gene CLEC12A antisense RNA 1 Neighboring gene uncharacterized LOC124902874 Neighboring gene C-type lectin domain family 12 member A Neighboring gene uncharacterized LOC102724020 Neighboring gene C-type lectin domain family 12 member B Neighboring gene C-type lectin domain family 1 member B pseudogene Neighboring gene C-type lectin domain containing 9A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2. Watson AA, et al. J Biol Chem, 2007 Feb 2. PMID 17132623
    2. C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits. Wang L, et al. Gastroenterology, 2016 May. PMID 26855187
    3. The platelet receptor CLEC-2 is active as a dimer. Watson AA, et al. Biochemistry, 2009 Nov 24. PMID 19824697
    4. A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation. Parguiña AF, et al. Blood, 2012 Dec 20. PMID 23053573
    5. High CLEC-2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma. Xiong Y, et al. Oncotarget, 2016 Sep 27. PMID 27564117, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis.
      Title: Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis.
    2. Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2.
      Title: Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2.
    3. Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling.
      Title: Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling.
    4. [Expression of Clec2 in Patients with Myelodysplastic Syndrome and Its Correlation with TPO].
      Title: [Expression of Clec2 in Patients with Myelodysplastic Syndrome and Its Correlation with TPO].
    5. Platelet membrane lipid rafts protein composition varies following GPVI and CLEC-2 receptors activation.
      Title: Platelet membrane lipid rafts protein composition varies following GPVI and CLEC-2 receptors activation.
    6. Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin.
      Title: Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin.
    7. Functional significance of the platelet immune receptors GPVI and CLEC-2.
      Title: Functional significance of the platelet immune receptors GPVI and CLEC-2.
    8. tetraspanin CD37 controls CLEC-2 membrane organization and provides new molecular insights into the mechanisms underlying CLEC-2-dependent dendritic cell migration.
      Title: C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.
    9. CLEC-2 may have a role in unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma
      Title: High CLEC-2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma.
    10. CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis, and might be targeted to prevent adverse events in patients at risk.
      Title: Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in platelet formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain family 1 member B
    Names
    C-type lectin-like receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099431.2 → NP_001092901.1  C-type lectin domain family 1 member B isoform b

      See identical proteins and their annotated locations for NP_001092901.1

      Status: VALIDATED

      Source sequence(s)
      AC091814
      Consensus CDS
      CCDS41751.1
      UniProtKB/Swiss-Prot
      Q9P126
      Related
      ENSP00000327169.6, ENST00000348658.4
      Conserved Domains (1) summary
      cd03593
      Location:69 → 185
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. NM_001393342.1 → NP_001380271.1  C-type lectin domain family 1 member B isoform a

      Status: VALIDATED

      Source sequence(s)
      AC091814
      Consensus CDS
      CCDS41752.1
      UniProtKB/Swiss-Prot
      Q6UWX7, Q8NHR6, Q9P126
      Conserved Domains (1) summary
      cd03593
      Location:102 → 218
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    3. NM_016509.4 → NP_057593.3  C-type lectin domain family 1 member B isoform a

      See identical proteins and their annotated locations for NP_057593.3

      Status: VALIDATED

      Source sequence(s)
      AC091814
      Consensus CDS
      CCDS41752.1
      UniProtKB/Swiss-Prot
      Q6UWX7, Q8NHR6, Q9P126
      Related
      ENSP00000298527.6, ENST00000298527.11
      Conserved Domains (1) summary
      cd03593
      Location:102 → 218
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      9993075..10001899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428938.1 → XP_047284894.1  C-type lectin domain family 1 member B isoform X1

      UniProtKB/Swiss-Prot
      Q6UWX7, Q8NHR6, Q9P126

    2. XM_011520685.3 → XP_011518987.1  C-type lectin domain family 1 member B isoform X2

      See identical proteins and their annotated locations for XP_011518987.1

      UniProtKB/Swiss-Prot
      Q9P126
      Conserved Domains (1) summary
      cd03593
      Location:69 → 185
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      9879239..9888052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372190.1 → XP_054228165.1  C-type lectin domain family 1 member B isoform X1

    2. XM_054372191.1 → XP_054228166.1  C-type lectin domain family 1 member B isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P126.2 GenPept UniProtKB/Swiss-Prot:Q9P126

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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