Cda cytidine deaminase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdaprovided by MGI
Official Full Name: cytidine deaminaseprovided by MGI
Primary source: MGI:MGI:1919519
See related: Ensembl:ENSMUSG00000028755 AllianceGenome:MGI:1919519
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2210401N16Rik
Summary: Enables cytidine deaminase activity and identical protein binding activity. Involved in UMP salvage. Is active in cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 159.2), kidney adult (RPKM 84.5) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 70.17 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (138065839..138095623, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (138338528..138368311, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Necessity of HuR/ELAVL1 for the activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification.
Title: Necessity of HuR/ELAVL1 for the activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification.
Data indicate that a combination cytosine deaminase (CDA)/uracil phosphoribosyltransferase protein (UPRT)-expressing adipose tissue-derived mesenchymal stem cells (AT-MSCs) with lysomustine has a superior antitumor effect in the lung carcinoma model compared to monotherapies with transfected AT-MSCs or lysomustine alone.
Title: Combined treatment, based on lysomustine administration with mesenchymal stem cells expressing cytosine deaminase therapy, leads to pronounced murine Lewis lung carcinoma growth inhibition.
Activation-induced cytidine deaminase plays an important role in the containment of autoimmune diseases by negative regulation of autoreactive B cells.
Title: Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.
On the basis of known structures, structural analysis further reveals two subclasses of homotetrameric CDAs that can be identified according to the position of the charge-neutralizing arginine residue.
Title: The 1.48 A resolution crystal structure of the homotetrameric cytidine deaminase from mouse.
a drug-resistance gene highly suitable for myeloprotective purposes, which might best be used in combination with selectable drug-resistance genes.
Title: Gene transfer of cytidine deaminase protects myelopoiesis from cytidine analogs in an in vivo murine transplant model.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cda (e-PCR), detects polymorphism
- UniSTS:506787

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytidine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytidine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables cytidine deaminase activity	ISO Inferred from Sequence Orthology more info
enables cytidine deaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deaminase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nucleoside binding	ISO Inferred from Sequence Orthology more info
enables nucleoside binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in CMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in UMP salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to external biotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in cytidine deamination	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytidine deamination	ISO Inferred from Sequence Orthology more info
involved_in cytidine deamination	ISS Inferred from Sequence or Structural Similarity more info
involved_in dCMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nucleotide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cycloheximide	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytidine deaminase

Names: cytidine aminohydrolase

NP_082452.1

EC 3.5.4.5

XP_006539259.1

EC 3.5.4.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028176.1 → NP_082452.1 cytidine deaminase

See identical proteins and their annotated locations for NP_082452.1

Status: PROVISIONAL

Source sequence(s)

BC050114

Consensus CDS

CCDS18826.1

UniProtKB/Swiss-Prot

P56389, Q9D7V3

Related

ENSMUSP00000030535.4, ENSMUST00000030535.4

Conserved Domains (1) summary

TIGR01354
Location:16 → 142

cyt_deam_tetra; cytidine deaminase, homotetrameric

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

138065839..138095623 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539196.4 → XP_006539259.1 cytidine deaminase isoform X1

Conserved Domains (1) summary

cl00269
Location:23 → 51

cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...