Zfp574 zinc finger protein 574 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp574provided by MGI
Official Full Name: zinc finger protein 574provided by MGI
Primary source: MGI:MGI:2442951
See related: Ensembl:ENSMUSG00000045252 AllianceGenome:MGI:2442951
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znf574; A630056B21Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and limb. Orthologous to human ZNF574 (zinc finger protein 574). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 59.4), ovary adult (RPKM 14.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 13.73 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24775099..24782917)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (25075674..25083492)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
Title: Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 574

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168506.2 → NP_001161978.1 zinc finger protein 574

See identical proteins and their annotated locations for NP_001161978.1

Status: VALIDATED

Source sequence(s)

AC125468, AK143997, BC059044

Consensus CDS

CCDS20971.1

UniProtKB/Swiss-Prot

Q3TDE5, Q3UNU1, Q8BKB5, Q8BY46

Conserved Domains (2) summary

COG5048
Location:498 → 852

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:500 → 520

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_175477.5 → NP_780686.1 zinc finger protein 574

See identical proteins and their annotated locations for NP_780686.1

Status: VALIDATED

Source sequence(s)

AC125468, AK143997, BC059044, BY087218

Consensus CDS

CCDS20971.1

UniProtKB/Swiss-Prot

Q3TDE5, Q3UNU1, Q8BKB5, Q8BY46

Related

ENSMUSP00000057817.10, ENSMUST00000053410.11

Conserved Domains (2) summary

COG5048
Location:498 → 852

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:500 → 520

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

24775099..24782917

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539850.3 → XP_006539913.1 zinc finger protein 574 isoform X1

Conserved Domains (2) summary

COG5048
Location:541 → 895

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:543 → 563

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006539852.5 → XP_006539915.1 zinc finger protein 574 isoform X2

See identical proteins and their annotated locations for XP_006539915.1

UniProtKB/Swiss-Prot

Q3TDE5, Q3UNU1, Q8BKB5, Q8BY46

Conserved Domains (2) summary

COG5048
Location:498 → 852

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:500 → 520

ZF_C2H2; C2H2 Zn finger [structural motif]