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    ANAPC5 anaphase promoting complex subunit 5 [ Homo sapiens (human) ]

    Gene ID: 51433, updated on 3-May-2024

    Summary

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    Official Symbol
    ANAPC5provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 5provided by HGNC
    Primary source
    HGNC:HGNC:15713
    See related
    Ensembl:ENSG00000089053 MIM:606948; AllianceGenome:HGNC:15713
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC5
    Summary
    This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 32.0), bone marrow (RPKM 28.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ANAPC5 in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (121308245..121354209, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (121299648..121345630, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121746048..121792012, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121661200-121661700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7159 Neighboring gene Sharpr-MPRA regulatory region 10951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121671545-121672172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4971 Neighboring gene purinergic receptor P2X 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121683587-121683800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121693396-121693896 Neighboring gene calcium/calmodulin dependent protein kinase kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121720271-121720878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121720879-121721486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4972 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121773208-121773399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121789289-121789964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121790641-121791316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121791317-121791990 Neighboring gene uncharacterized LOC124903037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7164 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:121838029-121838560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121838561-121839092 Neighboring gene MPRA-validated peak2014 silencer Neighboring gene ring finger protein 34 Neighboring gene lysine demethylase 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of anaphase-promoting complex 5 in balloon angioplasty-injured rat carotid arteries and mitogen-stimulated human vascular smooth muscle cells. Autieri MV. Biochem Biophys Res Commun, 2001 Apr 6. PMID 11401522
    2. Co‑expression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway. Xu M, et al. Mol Med Rep, 2017 Oct. PMID 28731177, Free PMC Article
    3. Cross-talk between APC/C and CBP/p300. Liu J, et al. Cancer Biol Ther, 2006 Jul. PMID 16861917
    4. Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Budhavarapu VN, et al. Cell Cycle, 2012 May 15. PMID 22580462, Free PMC Article
    5. The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation. Koloteva-Levine N, et al. Mol Cell Biol, 2004 May. PMID 15082755, Free PMC Article

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. coexpression of APC5 and Axin genes significantly downregulated Wnt signaling in human SW480 CRC cells and inhibited cell growth.
      Title: Co‑expression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway.
    2. Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
      Title: Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
    3. Studies indicate that APC/C(Cdh1) is required to maintain genomic stability.
      Title: The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.
    4. APC5 and APC7 suppress E1A-mediated transformation in a CBP/p300-dependent manner, indicating that these components of the APC/C may be targeted during cellular transformation
      Title: The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.
    5. Results show that Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) element of platelet-derived growth factor 2 mRNA.
      Title: The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 5
    Names
    cyclosome subunit 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137559.1 → NP_001131031.1  anaphase-promoting complex subunit 5 isoform b

      See identical proteins and their annotated locations for NP_001131031.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the internal coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in a shorter isoform (b) compared to isoform a.
      Source sequence(s)
      AA349724, AK025614, BX381618
      Consensus CDS
      CCDS45000.1
      UniProtKB/Swiss-Prot
      Q9UJX4
      Related
      ENSP00000415061.2, ENST00000441917.6
      Conserved Domains (3) summary
      sd00016
      Location:149 → 183
      Apc5; TPR repeat [structural motif]
      cd16270
      Location:1 → 66
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
      pfam12862
      Location:155 → 255
      ANAPC5; Anaphase-promoting complex subunit 5

    2. NM_001330489.2 → NP_001317418.1  anaphase-promoting complex subunit 5 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (c) is shorter but has the same N- and C-termini as isoform a.
      Source sequence(s)
      AA349724, AI879332, BC001950, BX381618, CR980654
      Consensus CDS
      CCDS81749.1
      UniProtKB/TrEMBL
      F5H0F9
      Related
      ENSP00000439875.1, ENST00000541887.5
      Conserved Domains (5) summary
      sd00016
      Location:248 → 282
      Apc5; TPR repeat [structural motif]
      sd00006
      Location:454 → 482
      TPR; TPR repeat [structural motif]
      cd16270
      Location:32 → 165
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
      pfam12862
      Location:254 → 354
      ANAPC5; Anaphase-promoting complex subunit 5
      pfam17874
      Location:439 → 685
      TPR_MalT; MalT-like TPR region

    3. NM_016237.5 → NP_057321.2  anaphase-promoting complex subunit 5 isoform a

      See identical proteins and their annotated locations for NP_057321.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AA349724, AI879332, BC001950, BX381618
      Consensus CDS
      CCDS9220.1
      UniProtKB/Swiss-Prot
      E9PFB2, Q8N4H7, Q9BQD4, Q9UJX4
      Related
      ENSP00000261819.3, ENST00000261819.8
      Conserved Domains (5) summary
      sd00016
      Location:248 → 282
      Apc5; TPR repeat [structural motif]
      sd00006
      Location:467 → 495
      TPR; TPR repeat [structural motif]
      cd16270
      Location:32 → 165
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
      pfam12862
      Location:254 → 354
      ANAPC5; Anaphase-promoting complex subunit 5
      pfam17874
      Location:452 → 698
      TPR_MalT; MalT-like TPR region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      121308245..121354209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      121299648..121345630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UJX4.2 GenPept UniProtKB/Swiss-Prot:Q9UJX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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