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    PDE4D phosphodiesterase 4D [ Homo sapiens (human) ]

    Gene ID: 5144, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PDE4Dprovided by HGNC
    Official Full Name
    phosphodiesterase 4Dprovided by HGNC
    Primary source
    HGNC:HGNC:8783
    See related
    Ensembl:ENSG00000113448 MIM:600129; AllianceGenome:HGNC:8783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2
    Summary
    This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
    Expression
    Broad expression in bone marrow (RPKM 7.8), lung (RPKM 3.1) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PDE4D in Genome Data Viewer
    Location:
    5q11.2-q12.1
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (58969038..60522128, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (59787596..61345916, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (58264865..59792113, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:57839100-57840299 Neighboring gene NANOG hESC enhancer GRCh37_chr5:57858257-57858782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16034 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86582 Neighboring gene long intergenic non-protein coding RNA 2108 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86593 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:58013208-58014189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16035 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86681 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:58186496-58187695 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58232852-58233452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58233453-58234051 Neighboring gene Sharpr-MPRA regulatory region 1719 Neighboring gene ribosomal protein L5 pseudogene 15 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:58276599-58277183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58298739-58299634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16036 Neighboring gene MPRA-validated peak5258 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58422602-58423512 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58423513-58424422 Neighboring gene MPRA-validated peak5260 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr5:58454460-58454961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16037 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:58624407-58625606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:58690566-58691066 Neighboring gene uncharacterized LOC107986347 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:58858724-58859374 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:59004928-59005660 Neighboring gene Sharpr-MPRA regulatory region 14831 Neighboring gene MPRA-validated peak5261 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:59063568-59064767 Neighboring gene uncharacterized LOC105378988 Neighboring gene NANOG hESC enhancer GRCh37_chr5:59096304-59096834 Neighboring gene uncharacterized LOC107986350 Neighboring gene NANOG hESC enhancer GRCh37_chr5:59165165-59165666 Neighboring gene microRNA 582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:59345282-59345782 Neighboring gene NANOG hESC enhancer GRCh37_chr5:59657334-59657835 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:59666235-59667434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22584 Neighboring gene RNA, U6 small nuclear 806, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:59710708-59711366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22587 Neighboring gene Sharpr-MPRA regulatory region 9229 Neighboring gene ribosomal protein L31 pseudogene 8 Neighboring gene SET pseudogene 21 Neighboring gene Sharpr-MPRA regulatory region 1909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16038 Neighboring gene uncharacterized LOC124900982 Neighboring gene prostate androgen-regulated transcript 1 Neighboring gene DEP domain containing 1B Neighboring gene calcium binding protein 39 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study. Song Q, et al. Hum Mol Genet, 2006 Aug 15. PMID 16835261, Free PMC Article
    2. Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Lin DC, et al. Proc Natl Acad Sci U S A, 2013 Apr 9. PMID 23536305, Free PMC Article
    3. Association of phosphodiesterase 4 polymorphism (rs702553) with blood pressure in the African American Study of Kidney Disease and Hypertension Genomics Study. Anthony EG, et al. Pharmacogenet Genomics, 2013 Aug. PMID 23778321
    4. [Association of rs966221 phosphodiesterase 4D gene's polymorphism with risk of myocardial infarction]. Pleskach HV, et al. Lik Sprava, 2012 Dec. PMID 23786009
    5. Genetic polymorphism in PDE4D gene and risk of ischemic stroke in Chinese population: a meta-analysis. Liu X, et al. PLoS One, 2013. PMID 23799094, Free PMC Article

    See all (253) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.
      Title: GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.
    2. Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study.
      Title: Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study.
    3. PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis.
      Title: PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis.
    4. Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis.
      Title: Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis.
    5. [Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population].
      Title: [Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population].
    6. PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children.
      Title: PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children.
    7. Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.
      Title: Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.
    8. Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis.
      Title: Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis.
    9. Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis.
      Title: Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis.
    10. The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease.
      Title: The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease.
    Submit: New GeneRIF Correction See all GeneRIFs (154)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Acrodysostosis 2 with or without hormone resistance
    MedGen: C3553250 OMIM: 614613 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2018-02-02)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2018-02-02)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    A whole genome association study of neuroticism using DNA pooling.
    EBI GWAS Catalog
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog
    Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
    EBI GWAS Catalog
    Genome-wide association of sleep and circadian phenotypes.
    EBI GWAS Catalog
    Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
    EBI GWAS Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog
    Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.
    EBI GWAS Catalog
    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
    EBI GWAS Catalog
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
    tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ97311, DKFZp686M11213

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity TAS
    Traceable Author Statement
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables beta-2 adrenergic receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cAMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables heterocyclic compound binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adrenergic receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to epinephrine stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in establishment of endothelial barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of heart contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of heart rate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-5 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cardiac muscle cell contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of cell communication by electrical coupling involved in cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of heart rate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of calcium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    NOT located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    3',5'-cyclic-AMP phosphodiesterase 4D
    Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    cAMP-specific phosphodiesterase PDE4D6
    phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
    testicular tissue protein Li 136
    NP_001098101.1
    NP_001159371.1
    NP_001184147.1
    NP_001184148.1
    NP_001184149.1
    NP_001184150.1
    NP_001184151.1
    NP_001184152.1
    NP_001336170.1
    NP_001336171.1
    NP_001336172.1
    NP_001351528.1
    NP_001351529.1
    NP_001351530.1
    NP_001351531.1
    NP_001351532.1
    NP_001351533.1
    NP_006194.2
    XP_011541771.1
    XP_011541775.1
    XP_016865055.1
    XP_016865056.1
    XP_024301878.1
    XP_024301880.1
    XP_047273249.1
    XP_047273250.1
    XP_047273251.1
    XP_047273252.1
    XP_047273253.1
    XP_047273254.1
    XP_047273255.1
    XP_047273256.1
    XP_047273257.1
    XP_054208753.1
    XP_054208754.1
    XP_054208755.1
    XP_054208756.1
    XP_054208757.1
    XP_054208758.1
    XP_054208759.1
    XP_054208760.1
    XP_054208761.1
    XP_054208762.1
    XP_054208763.1
    XP_054208764.1
    XP_054208765.1
    XP_054208766.1
    XP_054208767.1
    XP_054208768.1
    XP_054208769.1
    XP_054208770.1
    XP_054208771.1
    XP_054208772.1
    XP_054208773.1
    XP_054208774.1
    XP_054208775.1
    XP_054208776.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027957.2 RefSeqGene

      Range
      635604..1560292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104631.2 → NP_001098101.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4

      See identical proteins and their annotated locations for NP_001098101.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (PDE4D4, also known as isoform 1).
      Source sequence(s)
      AC027322, AC092343, BF197530, L20969
      Consensus CDS
      CCDS47213.1
      UniProtKB/Swiss-Prot
      O43433, Q08499, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q96HL4, Q9HCX7
      UniProtKB/TrEMBL
      A0A140VJR0
      Related
      ENSP00000345502.6, ENST00000340635.11
      Conserved Domains (1) summary
      pfam00233
      Location:461 → 702
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001165899.2 → NP_001159371.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D7

      See identical proteins and their annotated locations for NP_001159371.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D7 (also known as isoform 3) has a shorter and distinct N-terminus, compared to isoform PDE4D4. Variants 3 and 13 both encode the same isoform (PDE4D7).
      Source sequence(s)
      AC092343, AY245866, BI492585, DB230503
      Consensus CDS
      CCDS54859.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000423094.2, ENST00000502484.6
      Conserved Domains (2) summary
      pfam00233
      Location:400 → 641
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162 → 278
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    3. NM_001197218.2 → NP_001184147.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D5

      See identical proteins and their annotated locations for NP_001184147.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D5 (also known as isoform 4) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC027322, AC092343, AF012073, BF197530
      Consensus CDS
      CCDS56373.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000424852.1, ENST00000507116.6
      Conserved Domains (2) summary
      pfam00233
      Location:397 → 638
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:159 → 275
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    4. NM_001197219.2 → NP_001184148.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D8

      See identical proteins and their annotated locations for NP_001184148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D8 (also known as isoform 5) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC008791, AC092343, AF012073, AF536977, BF197530
      Consensus CDS
      CCDS56372.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000384806.2, ENST00000405755.6
      Conserved Domains (1) summary
      pfam00233
      Location:339 → 576
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. NM_001197220.2 → NP_001184149.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D9

      See identical proteins and their annotated locations for NP_001184149.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D9 (also known as isoform 6) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF012073, AY245867, BF197530
      Consensus CDS
      CCDS56371.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000425605.1, ENST00000503258.5
      Conserved Domains (2) summary
      pfam00233
      Location:331 → 572
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:93 → 209
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    6. NM_001197221.2 → NP_001184150.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D2

      See identical proteins and their annotated locations for NP_001184150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D2 (also known as isoform 7) is shorter at the N-terminus, compared to isoform PDE4D4. Variants 7 and 17 both encode the same isoform (PDE4D2).
      Source sequence(s)
      AC092343, AF012074, BF197530
      Consensus CDS
      CCDS56370.1
      UniProtKB/TrEMBL
      D6RHE0
      Related
      ENSP00000351800.6, ENST00000358923.10
      Conserved Domains (2) summary
      pfam00233
      Location:159 → 400
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1 → 37
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    7. NM_001197222.2 → NP_001184151.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D1

      See identical proteins and their annotated locations for NP_001184151.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D1 (also known as isoform 8) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF012074, BF197530, U50157
      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (1) summary
      pfam00233
      Location:237 → 478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    8. NM_001197223.2 → NP_001184152.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D6

      See identical proteins and their annotated locations for NP_001184152.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D6 (also known as isoform 9) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AF536975, BC036319, BF197530
      Consensus CDS
      CCDS56369.1
      UniProtKB/TrEMBL
      D6RHE0
      Related
      ENSP00000321739.8, ENST00000317118.12
      Conserved Domains (2) summary
      pfam00233
      Location:170 → 411
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:16 → 48
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    9. NM_001349241.2 → NP_001336170.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and coding region, compared to variant 1. Isoform 10 is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC091955, AC092343, AY245866, BI492585, DB230503
      Conserved Domains (2) summary
      pfam00233
      Location:390 → 631
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:152 → 268
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    10. NM_001349242.2 → NP_001336171.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and coding region, compared to variant 1. Isoform 11 is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC008791, AC092343, AC117527, BF197530, L20970, U50159
      Consensus CDS
      CCDS87297.1
      UniProtKB/TrEMBL
      A0A1B0GW84
      Related
      ENSP00000490821.1, ENST00000636120.1
      Conserved Domains (2) summary
      pfam00233
      Location:351 → 592
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:113 → 229
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    11. NM_001349243.2 → NP_001336172.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and coding region, compared to variant 1. Isoform 12 is shorter and has a distinct N-terminus, compared to isoform PDE4D4. Variants 12 and 18 both encode the same isoform (12).
      Source sequence(s)
      AC091955, AC092343, AY245866, BI492585, DB230503
      Conserved Domains (2) summary
      pfam00233
      Location:205 → 446
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1 → 83
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    12. NM_001364599.1 → NP_001351528.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variant 3, encodes isoform PDE4D7.
      Source sequence(s)
      AC008818, AC008829, AC008934, AC091955, AC092343
      Consensus CDS
      CCDS54859.1
      Conserved Domains (2) summary
      pfam00233
      Location:400 → 641
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162 → 278
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    13. NM_001364600.2 → NP_001351529.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC008829, AC008934, AC091955, AC109486

    14. NM_001364601.1 → NP_001351530.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC008829, AC027322

    15. NM_001364602.2 → NP_001351531.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC008829, AC027322, BC008390
      Consensus CDS
      CCDS93714.1
      Related
      ENSP00000425917.1, ENST00000502575.1
      Conserved Domains (1) summary
      pfam18100
      Location:159 → 204
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    16. NM_001364603.1 → NP_001351532.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 7, encodes isoform PDE4D2.
      Source sequence(s)
      AC027322, AC092343, AJ250854
      Consensus CDS
      CCDS56370.1
      UniProtKB/TrEMBL
      D6RHE0
      Conserved Domains (2) summary
      pfam00233
      Location:159 → 400
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1 → 37
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    17. NM_001364604.1 → NP_001351533.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 12, encodes isoform 12.
      Source sequence(s)
      AC008829, AC092343, AC117527
      Conserved Domains (2) summary
      pfam00233
      Location:205 → 446
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1 → 83
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    18. NM_006203.5 → NP_006194.2  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D3

      See identical proteins and their annotated locations for NP_006194.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D3 (also known as isoform 2) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
      Source sequence(s)
      AC092343, AC117527, BF197530, L20970, U50159
      Consensus CDS
      CCDS54858.1
      UniProtKB/Swiss-Prot
      Q08499
      Related
      ENSP00000353152.5, ENST00000360047.9
      Conserved Domains (2) summary
      pfam00233
      Location:325 → 566
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:87 → 203
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      58969038..60522128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446112.2 → XP_024301880.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

      Conserved Domains (2) summary
      pfam00233
      Location:400 → 641
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162 → 278
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    2. XM_024446110.2 → XP_024301878.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

      Conserved Domains (1) summary
      pfam00233
      Location:449 → 686
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. XM_047417295.1 → XP_047273251.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X4

    4. XM_017009566.1 → XP_016865055.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (2) summary
      pfam00233
      Location:400 → 641
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162 → 278
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    5. XM_047417294.1 → XP_047273250.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    6. XM_011543473.2 → XP_011541775.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

      See identical proteins and their annotated locations for XP_011541775.1

      UniProtKB/Swiss-Prot
      Q08499
      Conserved Domains (2) summary
      pfam00233
      Location:400 → 641
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162 → 278
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    7. XM_047417293.1 → XP_047273249.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    8. XM_011543469.2 → XP_011541771.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

      See identical proteins and their annotated locations for XP_011541771.1

      Conserved Domains (1) summary
      pfam00233
      Location:449 → 686
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    9. XM_017009567.1 → XP_016865056.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X3

      Conserved Domains (2) summary
      pfam00233
      Location:395 → 636
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:157 → 273
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    10. XM_047417297.1 → XP_047273253.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X6

    11. XM_047417296.1 → XP_047273252.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X5

    12. XM_047417298.1 → XP_047273254.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X7

    13. XM_047417299.1 → XP_047273255.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X7

    14. XM_047417301.1 → XP_047273257.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X9

    15. XM_047417300.1 → XP_047273256.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      59787596..61345916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352788.1 → XP_054208763.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    2. XM_054352780.1 → XP_054208755.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    3. XM_054352789.1 → XP_054208764.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    4. XM_054352790.1 → XP_054208765.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    5. XM_054352793.1 → XP_054208768.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    6. XM_054352782.1 → XP_054208757.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    7. XM_054352781.1 → XP_054208756.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    8. XM_054352783.1 → XP_054208758.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    9. XM_054352785.1 → XP_054208760.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    10. XM_054352792.1 → XP_054208767.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    11. XM_054352795.1 → XP_054208770.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X4

    12. XM_054352784.1 → XP_054208759.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    13. XM_054352778.1 → XP_054208753.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    14. XM_054352787.1 → XP_054208762.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    15. XM_054352791.1 → XP_054208766.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    16. XM_054352779.1 → XP_054208754.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    17. XM_054352786.1 → XP_054208761.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    18. XM_054352794.1 → XP_054208769.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X3

    19. XM_054352799.1 → XP_054208774.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X6

    20. XM_054352798.1 → XP_054208773.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X5

    21. XM_054352797.1 → XP_054208772.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X5

    22. XM_054352796.1 → XP_054208771.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X10

    23. XM_054352800.1 → XP_054208775.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X7

    24. XM_054352801.1 → XP_054208776.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08499.2 GenPept UniProtKB/Swiss-Prot:Q08499

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