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    Matr3 matrin 3 [ Mus musculus (house mouse) ]

    Gene ID: 17184, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Matr3provided by MGI
    Official Full Name
    matrin 3provided by MGI
    Primary source
    MGI:MGI:1298379
    See related
    Ensembl:ENSMUSG00000037236 AllianceGenome:MGI:1298379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0723; 1110061A14Rik; 2810017I02Rik; D030046F20Rik
    Summary
    Predicted to enable identical protein binding activity and miRNA binding activity. Acts upstream of or within blastocyst formation; heart valve development; and ventricular septum development. Located in nucleus. Is expressed in several structures, including blood vessel layer; branchial arch; heart; lung; and telencephalon. Used to study amyotrophic lateral sclerosis type 21. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 21. Orthologous to human MATR3 (matrin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 68.8), CNS E18 (RPKM 62.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Matr3 in Genome Data Viewer
    Location:
    18 B2; 18 19.14 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35686462..35724526)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35562158..35592045)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene predicted gene, 41692 Neighboring gene microRNA 1949 Neighboring gene small nucleolar RNA, H/ACA box 74A Neighboring gene small nucleolar RNA host gene 4 Neighboring gene STARR-positive B cell enhancer ABC_E9973 Neighboring gene STARR-positive B cell enhancer ABC_E5651 Neighboring gene polyadenylate-binding protein-interacting protein 2 Neighboring gene solute carrier family 23 (nucleobase transporters), member 1 Neighboring gene STARR-seq mESC enhancer starr_44241 Neighboring gene STARR-seq mESC enhancer starr_44242 Neighboring gene marginal zone B and B1 cell-specific protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor. Cheng X, et al. Mol Metab, 2024 Aug. PMID 38936659, Free PMC Article
    2. Heterogeneity of Matrin 3 in the developing and aging murine central nervous system. Rayaprolu S, et al. J Comp Neurol, 2016 Oct 1. PMID 26878116, Free PMC Article
    3. MATR3 F115C knock-in mice do not exhibit motor defects or neuropathological features of ALS. van Bruggen R, et al. Biochem Biophys Res Commun, 2021 Sep 3. PMID 34182213
    4. MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS. Dominick M, et al. Biochem Biophys Res Commun, 2023 Feb 19. PMID 36689813, Free PMC Article
    5. Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture. Cha HJ, et al. Nat Commun, 2021 Oct 29. PMID 34716321, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor.
      Title: Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor.
    2. MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS.
      Title: MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS.
    3. Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture.
      Title: Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture.
    4. MATR3 F115C knock-in mice do not exhibit motor defects or neuropathological features of ALS.
      Title: MATR3 F115C knock-in mice do not exhibit motor defects or neuropathological features of ALS.
    5. Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.
      Title: Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.
    6. proteomic approach revealed that Matrin-3 phosphorylation was essential for FGF2-dependent maintenance of NSCs in vitro and in vivo.
      Title: Matrin-3 is essential for fibroblast growth factor 2-dependent maintenance of neural stem cells.
    7. Matrin 3 (MATR3) is a novel protein interactor of PABPN1. MATR3 together with PABPN1 is required for normal paraspeckle function.
      Title: Nuclear poly(A) binding protein 1 (PABPN1) and Matrin3 interact in muscle cells and regulate RNA processing.
    8. Matrin 3 declines significantly in the central nervous system through early development and young adulthood before stabilizing.
      Title: Heterogeneity of Matrin 3 in the developing and aging murine central nervous system.
    9. Matr3(Gt-ex13) gene trap insertion disturb the polyadenylation of MATR3 transcripts and alter Matrin 3 protein expression.
      Title: MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.
    10. Matrin 3 interacts specifically with the heat shock proteins glucose-regulated protein 78, GRP75 and glutathione S-transferase pi isoform 2.
      Title: Matrin 3 co-immunoprecipitates with the heat shock proteins glucose-regulated protein 78 (GRP78), GRP75 and glutathione S-transferase π isoform 2 (GSTπ2) in thymoma cells.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blastocyst formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart valve development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-transcriptional regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    matrin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399983.1 → NP_001386912.1  matrin-3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/Swiss-Prot
      Q8K310
      UniProtKB/TrEMBL
      Q5BL18

    2. NM_001399984.1 → NP_001386913.1  matrin-3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/Swiss-Prot
      Q8K310
      UniProtKB/TrEMBL
      Q5BL18
      Related
      ENSMUSP00000158074.2, ENSMUST00000235199.2

    3. NM_001399985.1 → NP_001386914.1  matrin-3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/Swiss-Prot
      Q8K310
      UniProtKB/TrEMBL
      Q5BL18

    4. NM_001399986.1 → NP_001386915.1  matrin-3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/Swiss-Prot
      Q8K310
      UniProtKB/TrEMBL
      Q5BL18

    5. NM_001399988.1 → NP_001386917.1  matrin-3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC121821

    6. NM_001399989.1 → NP_001386918.1  matrin-3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/TrEMBL
      A0A494BAD4
      Related
      ENSMUSP00000158036.2, ENSMUST00000237365.2

    7. NM_001399990.1 → NP_001386919.1  matrin-3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/TrEMBL
      A0A494BAZ7
      Related
      ENSMUSP00000157641.2, ENSMUST00000237061.2

    8. NM_001399991.1 → NP_001386920.1  matrin-3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/TrEMBL
      A0A494BAZ7
      Related
      ENSMUSP00000158418.2, ENSMUST00000235960.2

    9. NM_001399992.1 → NP_001386921.1  matrin-3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/TrEMBL
      A0A494BAZ7
      Related
      ENSMUSP00000158302.2, ENSMUST00000236507.2

    10. NM_001399993.1 → NP_001386922.1  matrin-3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/TrEMBL
      A0A494BAZ7

    11. NM_001414500.1 → NP_001401429.1  matrin-3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/Swiss-Prot
      Q8K310
      UniProtKB/TrEMBL
      Q5BL18

    12. NM_001414501.1 → NP_001401430.1  matrin-3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC121821
      UniProtKB/Swiss-Prot
      Q8K310
      UniProtKB/TrEMBL
      Q5BL18

    13. NM_001414502.1 → NP_001401431.1  matrin-3 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC121821

    14. NM_010771.7 → NP_034901.2  matrin-3 isoform a

      See identical proteins and their annotated locations for NP_034901.2

      Status: VALIDATED

      Source sequence(s)
      AC121821
      Consensus CDS
      CCDS29142.1
      UniProtKB/Swiss-Prot
      Q8K310
      UniProtKB/TrEMBL
      Q3TTX0, Q4FJT0, Q5BL18
      Related
      ENSMUSP00000125761.2, ENSMUST00000166793.10
      Conserved Domains (4) summary
      smart00451
      Location:797 → 832
      ZnF_U1; U1-like zinc finger
      COG5271
      Location:567 → 777
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd12714
      Location:398 → 473
      RRM1_MATR3; RNA recognition motif 1 in vertebrate matrin-3
      cd12715
      Location:496 → 575
      RRM2_MATR3; RNA recognition motif 2 in vertebrate matrin-3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      35686462..35724526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K310.1 GenPept UniProtKB/Swiss-Prot:Q8K310

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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