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    Zfp526 zinc finger protein 526 [ Mus musculus (house mouse) ]

    Gene ID: 210172, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp526provided by MGI
    Official Full Name
    zinc finger protein 526provided by MGI
    Primary source
    MGI:MGI:2445181
    See related
    Ensembl:ENSMUSG00000046541 AllianceGenome:MGI:2445181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf526; D030024H03Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF526 (zinc finger protein 526). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 12.7), thymus adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp526 in Genome Data Viewer
    Location:
    7 A3; 7 13.73 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24919272..24929688)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25219849..25227876)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene POU domain, class 2, transcription factor 2 Neighboring gene RIKEN cDNA D930028M14 gene Neighboring gene STARR-seq mESC enhancer starr_18292 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25990365-25990647 Neighboring gene STARR-seq mESC enhancer starr_18294 Neighboring gene death effector domain-containing DNA binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E868 Neighboring gene STARR-positive B cell enhancer ABC_E1724 Neighboring gene RIKEN cDNA 9130221H12 gene Neighboring gene microRNA 7048 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26024418-26024601 Neighboring gene glycogen synthase kinase 3 alpha Neighboring gene STARR-positive B cell enhancer ABC_E3706 Neighboring gene STARR-seq mESC enhancer starr_18298 Neighboring gene predicted gene, 53354 Neighboring gene Ets2 repressor factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC106217

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 526

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175436.5 → NP_780645.1  zinc finger protein 526

      See identical proteins and their annotated locations for NP_780645.1

      Status: VALIDATED

      Source sequence(s)
      AK050839, BX636779, CJ076017
      Consensus CDS
      CCDS20975.1
      UniProtKB/Swiss-Prot
      Q4VA17, Q69Z58, Q8BI66, Q8BIH7
      Related
      ENSMUSP00000053567.5, ENSMUST00000055604.6
      Conserved Domains (2) summary
      sd00017
      Location:479 → 499
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:491 → 516
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24919272..24929688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539713.5 → XP_006539776.1  zinc finger protein 526 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:511 → 531
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:523 → 548
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006539716.4 → XP_006539779.1  zinc finger protein 526 isoform X2

      See identical proteins and their annotated locations for XP_006539779.1

      UniProtKB/Swiss-Prot
      Q4VA17, Q69Z58, Q8BI66, Q8BIH7
      Conserved Domains (2) summary
      sd00017
      Location:479 → 499
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:491 → 516
      zf-H2C2_2; Zinc-finger double domain

    3. XM_006539715.5 → XP_006539778.1  zinc finger protein 526 isoform X2

      See identical proteins and their annotated locations for XP_006539778.1

      UniProtKB/Swiss-Prot
      Q4VA17, Q69Z58, Q8BI66, Q8BIH7
      Conserved Domains (2) summary
      sd00017
      Location:479 → 499
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:491 → 516
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BI66.1 GenPept UniProtKB/Swiss-Prot:Q8BI66

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