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    Camsap2 calmodulin regulated spectrin-associated protein family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 67886, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Camsap2provided by MGI
    Official Full Name
    calmodulin regulated spectrin-associated protein family, member 2provided by MGI
    Primary source
    MGI:MGI:1922434
    See related
    Ensembl:ENSMUSG00000041570 AllianceGenome:MGI:1922434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Camsap1l1; mKIAA1078; 1600013L13Rik; 4930541M15Rik
    Summary
    Enables microtubule minus-end binding activity. Involved in regulation of organelle organization. Located in ciliary basal body and microtubule minus-end. Is expressed in jaw bone; liver; lung; nervous system; and neural retina. Orthologous to human CAMSAP2 (calmodulin regulated spectrin associated protein family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 12.4), whole brain E14.5 (RPKM 11.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Camsap2 in Genome Data Viewer
    Location:
    1 E4; 1 59.61 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136195861..136273855, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136268123..136346117, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02404 Neighboring gene innate immunity activator Neighboring gene predicted gene 3878 Neighboring gene G protein-coupled receptor 25 Neighboring gene RIKEN cDNA 9230116N13 gene Neighboring gene STARR-seq mESC enhancer starr_02406 Neighboring gene DEAD box helicase 59 Neighboring gene STARR-positive B cell enhancer ABC_E993 Neighboring gene kinesin family member 14 Neighboring gene predicted gene 29485

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficiency of CAMSAP2 impairs olfaction and the morphogenesis of mitral cells. Zhou Z, et al. EMBO Rep, 2024 Jul. PMID 38839944, Free PMC Article
    2. CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway. Wang X, et al. Sci Rep, 2022 Oct 7. PMID 36207462, Free PMC Article
    3. CAMSAP3 maintains neuronal polarity through regulation of microtubule stability. Pongrakhananon V, et al. Proc Natl Acad Sci U S A, 2018 Sep 25. PMID 30190432, Free PMC Article
    4. CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells. Coquand L, et al. J Cell Biol, 2021 Aug 2. PMID 34019079, Free PMC Article
    5. CAMSAP3 facilitates basal body polarity and the formation of the central pair of microtubules in motile cilia. Robinson AM, et al. Proc Natl Acad Sci U S A, 2020 Jun 16. PMID 32482850, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency of CAMSAP2 impairs olfaction and the morphogenesis of mitral cells.
      Title: Deficiency of CAMSAP2 impairs olfaction and the morphogenesis of mitral cells.
    2. [High expression of CAMSAP2 promotes invasion and metastasis of gastric cancer cells by upregulating TGF-beta signaling].
      Title: [High expression of CAMSAP2 promotes invasion and metastasis of gastric cancer cells by upregulating TGF-β signaling].
    3. CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway.
      Title: CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway.
    4. CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells.
      Title: CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells.
    5. CAMSAP2 and -3 work together to maintain noncentrosomal microtubules in epithelial cells, suppressing the microtubule-organizing ability of the centrosome.
      Title: Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule minus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule minus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule minus-end binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables spectrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axon development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of organelle organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of organelle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule end ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with microtubule minus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule minus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with microtubule minus-end ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-regulated spectrin-associated protein 2
    Names
    calmodulin-regulated spectrin-associated protein 1-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347109.1 → NP_001334038.1  calmodulin-regulated spectrin-associated protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC120875, AC124550
      Consensus CDS
      CCDS83598.1
      UniProtKB/TrEMBL
      A0A0A6YY67, B2RRE3
      Related
      ENSMUSP00000142299.2, ENSMUST00000192314.2

    2. NM_001347110.1 → NP_001334039.1  calmodulin-regulated spectrin-associated protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC120875, AC124550
      Consensus CDS
      CCDS83597.1
      UniProtKB/Swiss-Prot
      B7ZNI4, Q80TK8, Q8C1B1, Q8C4J5
      UniProtKB/TrEMBL
      B2RRE3
      Related
      ENSMUSP00000142166.2, ENSMUST00000192001.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      136195861..136273855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529832.3 → XP_006529895.1  calmodulin-regulated spectrin-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RRE3
      Conserved Domains (4) summary
      PHA03247
      Location:917 → 1028
      PHA03247; large tegument protein UL36; Provisional
      pfam11971
      Location:237 → 315
      CAMSAP_CH; CAMSAP CH domain
      pfam08683
      Location:1342 → 1460
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam17095
      Location:731 → 789
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    2. XM_006529834.4 → XP_006529897.1  calmodulin-regulated spectrin-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      B2RRE3
      Conserved Domains (4) summary
      PHA03247
      Location:906 → 1017
      PHA03247; large tegument protein UL36; Provisional
      pfam11971
      Location:226 → 304
      CAMSAP_CH; CAMSAP CH domain
      pfam08683
      Location:1331 → 1449
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam17095
      Location:720 → 778
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    3. XM_011248066.4 → XP_011246368.1  calmodulin-regulated spectrin-associated protein 2 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:515 → 626
      PHA03247; large tegument protein UL36; Provisional
      pfam08683
      Location:940 → 1058
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam17095
      Location:329 → 387
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    4. XM_036153216.1 → XP_036009109.1  calmodulin-regulated spectrin-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      B2RRE3
      Conserved Domains (3) summary
      PHA03247
      Location:917 → 1028
      PHA03247; large tegument protein UL36; Provisional
      pfam11971
      Location:237 → 315
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:731 → 789
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    RNA

    1. XR_004934125.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081360.1: Suppressed sequence

      Description
      NM_001081360.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C1B1.3 GenPept UniProtKB/Swiss-Prot:Q8C1B1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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