Ct55 cancer/testis antigen 55 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ct55provided by MGI
Official Full Name: cancer/testis antigen 55provided by MGI
Primary source: MGI:MGI:1922263
See related: Ensembl:ENSMUSG00000055555 AllianceGenome:MGI:1922263
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930502E18Rik
Summary: Involved in spermatogenesis. Located in acrosomal vesicle and sperm flagellum. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 7. Orthologous to human CT55 (cancer/testis antigen 55). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 2.0), testis adult (RPKM 1.6) and 3 other tissues See more
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Genomic context

Location:: X A5; X 29.99 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (52726622..52740532)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (53724655..53738565)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.
Title: Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.
CT55 acts as an accelerator of tumor necrosis factor (TNF)-alpha-induced nuclear factor-kappaB (NF-kappaB) signaling. Upon stimulation with TNF-alpha, CT55 interacts with the IkappaB kinase (IKK) complex, which increases the phosphorylation of IKKalpha/beta and activates IKK-p65 signaling, while knockout of CT55 blocks IKK-p65 signaling. Collectively, CT55 deficiency suppresses the development of colitis-associated can...
Title: Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-κB signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cancer/testis antigen 55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029142.1 → NP_083418.1 cancer/testis antigen 55

See identical proteins and their annotated locations for NP_083418.1

Status: PROVISIONAL

Source sequence(s)

BC115664

Consensus CDS

CCDS30136.1

UniProtKB/Swiss-Prot

Q14BQ3, Q9D585

Related

ENSMUSP00000064619.2, ENSMUST00000069209.2

Conserved Domains (1) summary

pfam14444
Location:176 → 228

S1-like; S1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

52726622..52740532

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535359.2 → XP_006535422.1 cancer/testis antigen 55 isoform X1

UniProtKB/TrEMBL

A0A9L6KDX3

Conserved Domains (1) summary

pfam14444
Location:111 → 163

S1-like