U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ece2 endothelin converting enzyme 2 [ Mus musculus (house mouse) ]

    Gene ID: 107522, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ece2provided by MGI
    Official Full Name
    endothelin converting enzyme 2provided by MGI
    Primary source
    MGI:MGI:1101356
    See related
    Ensembl:ENSMUSG00000022842 AllianceGenome:MGI:1101356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ece-2; 1810009K13Rik; 6330509A19Rik; 9630025D12Rik; Eef1akmt4-Ece2
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to act upstream of or within peptide hormone processing. Predicted to be located in Golgi membrane; trans-Golgi network; and transport vesicle membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; genitourinary system; gut; heart; and nervous system. Orthologous to several human genes including ECE2 (endothelin converting enzyme 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.8), CNS E18 (RPKM 4.3) and 28 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ece2 in Genome Data Viewer
    Location:
    16 A3; 16 12.48 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20448601..20464665)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20629851..20645915)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10894 Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene Eef1akmt4-endothelin converting enzyme 2 readthrough Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Endothelin-converting enzyme 2 differentially regulates opioid receptor activity. Gupta A, et al. Br J Pharmacol, 2015 Jan. PMID 24990314, Free PMC Article
    2. Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. Miller LK, et al. J Neurochem, 2011 Dec. PMID 21972895, Free PMC Article
    3. Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. Rodriguiz RM, et al. Genes Brain Behav, 2008 Jun. PMID 21450041, Free PMC Article
    4. Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. Emoto N, et al. J Biol Chem, 1995 Jun 23. PMID 7797512
    5. Major amyloid-β-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex. Pacheco-Quinto J, et al. Neurobiol Aging, 2016 Dec. PMID 27644077, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It is a amyloid beta degrading enzyme and is expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex.
      Title: Major amyloid-β-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex.
    2. These results suggest that ECE2, by selectively processing endogenous opioid peptides in the endocytic compartment, plays a role in modulating opioid receptor activity
      Title: Endothelin-converting enzyme 2 differentially regulates opioid receptor activity.
    3. a role for differential modulation of opioid receptor signaling by post-endocytic processing of peptide agonists by ECE2.
      Title: Opioid receptor function is regulated by post-endocytic peptide processing.
    4. ECE-2 has a role in the non-classical processing of spinal cord peptides and morphine responses, including the cleavage of a number of neuropeptides at non-classical sites in vitro.
      Title: Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord.
    5. deficits in learning and memory in ECE2 knockout mice may provide unique insights into processes that may contribute to this disease and possible other disorders of cognition
      Title: Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory.
    6. The PL405 assay is thus the first tool to study ECE-2 inhibition using high throughput screening or for ex vivo ECE-2 quantification.
      Title: Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay.
    7. ECE2 has a role in limiting Abeta accumulation in the mouse brain
      Title: Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.
    8. novel four subisoforms of ECE-2 that differ in their N-terminal cytoplasmic tails
      Title: Molecular isolation and characterization of novel four subisoforms of ECE-2.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC144385, MGC144386

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptide hormone processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in transport vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    EEF1AKMT4-ECE2 readthrough transcript protein
    NP_647454.2
    NP_808811.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139293.2 → NP_647454.2  EEF1AKMT4-ECE2 readthrough transcript protein isoform d

      See identical proteins and their annotated locations for NP_647454.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC087898, AF489572, AU080537
      Consensus CDS
      CCDS28052.1
      UniProtKB/Swiss-Prot
      B2RQR8, E9Q896
      UniProtKB/TrEMBL
      Q923T6
      Related
      ENSMUSP00000003898.6, ENSMUST00000003898.12
      Conserved Domains (1) summary
      cd08662
      Location:112 → 761
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    2. NM_177942.1 → NP_808811.1  EEF1AKMT4-ECE2 readthrough transcript protein isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5, also known as 2-b1) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (e, also known as 2b-1) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC087898, AF489571, AF489572, AU080537
      Consensus CDS
      CCDS49796.1
      UniProtKB/TrEMBL
      Q80Z58
      Related
      ENSMUSP00000119693.2, ENSMUST00000133344.8
      Conserved Domains (2) summary
      cd08662
      Location:83 → 732
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:72 → 725
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20448601..20464665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RQR8.1 GenPept UniProtKB/Swiss-Prot:B2RQR8
    P0DPD9.1 GenPept UniProtKB/Swiss-Prot:P0DPD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools