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    Clint1 clathrin interactor 1 [ Mus musculus (house mouse) ]

    Gene ID: 216705, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Clint1provided by MGI
    Official Full Name
    clathrin interactor 1provided by MGI
    Primary source
    MGI:MGI:2144243
    See related
    Ensembl:ENSMUSG00000006169 AllianceGenome:MGI:2144243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Enth; Epn4; C530049I24Rik; F630206G17Rik
    Summary
    Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in clathrin coat assembly and endocytosis. Predicted to be located in Golgi apparatus; clathrin-coated vesicle; and nucleoplasm. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Is expressed in several structures, including craniocervical region bone; respiratory system cartilage; salivary gland primordium; sensory organ; and thoracic segment skeleton. Orthologous to human CLINT1 (clathrin interactor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 47.1), genital fat pad adult (RPKM 44.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clint1 in Genome Data Viewer
    Location:
    11 B1.1; 11 27.45 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (45742797..45801452)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (45851944..45910625)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F630206G17 gene Neighboring gene ferritin light chain 1 pseudogene Neighboring gene predicted gene, 53698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:45665211-45665394 Neighboring gene STARR-seq mESC enhancer starr_29303 Neighboring gene U7 snRNP-specific Sm-like protein LSM11 Neighboring gene STARR-positive B cell enhancer ABC_E5218 Neighboring gene STARR-positive B cell enhancer ABC_E11765 Neighboring gene tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EpsinR, a target for pyrenocine B, role in endogenous MHC-II-restricted antigen presentation. Shishido T, et al. Eur J Immunol, 2014 Nov. PMID 25196058
    2. Characterization of a gamma-adaptin ear-binding motif in enthoprotin. Wasiak S, et al. FEBS Lett, 2003 Dec 18. PMID 14675752
    3. Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. Rodríguez-Fraticelli AE, et al. Nat Cell Biol, 2015 Mar. PMID 25706235, Free PMC Article
    4. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. McIntire JJ, et al. Nat Immunol, 2001 Dec. PMID 11725301
    5. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0171, mKIAA0171

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    clathrin interactor 1
    Names
    ENTH domain containing protein
    enthoprotin
    epsin 4
    epsin-related protein
    epsinR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045520.5 → NP_001038985.2  clathrin interactor 1 isoform 1

      See identical proteins and their annotated locations for NP_001038985.2

      Status: VALIDATED

      Source sequence(s)
      AL645948
      Consensus CDS
      CCDS36130.1
      UniProtKB/TrEMBL
      Q3UPG6, Q5SUH7
      Related
      ENSMUSP00000104883.2, ENSMUST00000109260.3
      Conserved Domains (2) summary
      cd03571
      Location:23 → 146
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
      pfam15279
      Location:378 → 563
      SOBP; Sine oculis-binding protein

    2. NM_001346760.3 → NP_001333689.1  clathrin interactor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645948
      Consensus CDS
      CCDS83796.1
      UniProtKB/TrEMBL
      Q3UPG6, Q5SUH6
      Related
      ENSMUSP00000104884.4, ENSMUST00000109261.11

    3. NM_001363484.2 → NP_001350413.1  clathrin interactor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645948
      UniProtKB/TrEMBL
      Q3UPG6
      Conserved Domains (3) summary
      cd03571
      Location:23 → 146
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
      pfam09606
      Location:467 → 587
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13634
      Location:329 → 412
      Nucleoporin_FG; Nucleoporin FG repeat region

    4. NM_001404779.1 → NP_001391708.1  clathrin interactor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645948

    5. NM_001404780.1 → NP_001391709.1  clathrin interactor 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL645948

    6. NM_001404781.1 → NP_001391710.1  clathrin interactor 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL645948

    7. NM_001404782.1 → NP_001391711.1  clathrin interactor 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL645948

    8. NM_001404784.1 → NP_001391713.1  clathrin interactor 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL645948

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      45742797..45801452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KN9.2 GenPept UniProtKB/Swiss-Prot:Q99KN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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