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    Fnip2 folliculin interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 329679, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fnip2provided by MGI
    Official Full Name
    folliculin interacting protein 2provided by MGI
    Primary source
    MGI:MGI:2683054
    See related
    Ensembl:ENSMUSG00000061175 AllianceGenome:MGI:2683054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1450; D630023B12Rik
    Summary
    Predicted to enable ATPase inhibitor activity and protein-folding chaperone binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage. Acts upstream of or within with a positive effect on negative regulation of cell population proliferation. Located in cytoplasm. Orthologous to human FNIP2 (folliculin interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 5.2), placenta adult (RPKM 4.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fnip2 in Genome Data Viewer
    Location:
    3 E3; 3 34.91 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79363556..79475458, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79455971..79568151, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 2 Neighboring gene RIKEN cDNA 6430573P05 gene Neighboring gene STARR-seq mESC enhancer starr_07995 Neighboring gene predicted gene, 40072 Neighboring gene sperm microtubule inner protein 2 Neighboring gene STARR-seq mESC enhancer starr_07997 Neighboring gene STARR-seq mESC enhancer starr_07998 Neighboring gene STARR-seq mESC enhancer starr_07999 Neighboring gene STARR-seq mESC enhancer starr_08000 Neighboring gene STARR-seq mESC enhancer starr_08002 Neighboring gene RIKEN cDNA 4930589L23 gene Neighboring gene STARR-seq mESC enhancer starr_08006 Neighboring gene peptidylprolyl isomerase D (cyclophilin D) Neighboring gene electron transferring flavoprotein, dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3' untranslated region. Fernández LP, et al. Genome Biol, 2022 Oct 31. PMID 36316722, Free PMC Article
    2. Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA. Lim TH, et al. DNA Repair (Amst), 2012 Mar 1. PMID 22209521
    3. A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA. Komori K, et al. Oncogene, 2009 Feb 26. PMID 19137017
    4. Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1. Shillingford JM, et al. Am J Physiol Renal Physiol, 2023 Apr 1. PMID 36794754, Free PMC Article
    5. Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. Hasumi H, et al. Proc Natl Acad Sci U S A, 2015 Mar 31. PMID 25775561, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn
      Title: Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.
    2. The involvement of the AMPK-MAPO1-FLCN complex in the signaling pathway of apoptosis, is described.
      Title: Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATPase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FNIP-folliculin RagC/D GAP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    folliculin-interacting protein 2
    Names
    FNIP1-like protein
    O6-methylguanine-induced apoptosis 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162999.3 → NP_001156471.1  folliculin-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001156471.1

      Status: VALIDATED

      Source sequence(s)
      AC113945, AC142502
      Consensus CDS
      CCDS50934.1
      UniProtKB/Swiss-Prot
      Q80TD3
      Related
      ENSMUSP00000075497.5, ENSMUST00000076136.7
      Conserved Domains (3) summary
      pfam14636
      Location:42 → 164
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:293 → 526
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:921 → 1104
      FNIP_C; Folliculin-interacting protein C-terminus

    2. NM_001405166.1 → NP_001392095.1  folliculin-interacting protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113945, AC142502

    3. NM_001405167.1 → NP_001392096.1  folliculin-interacting protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113945, AC142502

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      79363556..79475458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252651.1 → XP_030108511.1  folliculin-interacting protein 2 isoform X5

      Conserved Domains (3) summary
      pfam14636
      Location:56 → 111
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:274 → 507
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:902 → 1085
      FNIP_C; Folliculin-interacting protein C-terminus

    2. XM_036163138.1 → XP_036019031.1  folliculin-interacting protein 2 isoform X6

      UniProtKB/TrEMBL
      A7E1X7
      Conserved Domains (3) summary
      pfam14636
      Location:42 → 111
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:244 → 477
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:872 → 1055
      FNIP_C; Folliculin-interacting protein C-terminus

    3. XM_017319620.3 → XP_017175109.1  folliculin-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      D3YUC5
      Related
      ENSMUSP00000115275.2, ENSMUST00000133154.7
      Conserved Domains (3) summary
      pfam14636
      Location:42 → 160
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:323 → 556
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:951 → 1134
      FNIP_C; Folliculin-interacting protein C-terminus

    4. XM_017319622.3 → XP_017175111.1  folliculin-interacting protein 2 isoform X4

      Conserved Domains (3) summary
      pfam14636
      Location:69 → 138
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:301 → 534
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:929 → 1112
      FNIP_C; Folliculin-interacting protein C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TD3.2 GenPept UniProtKB/Swiss-Prot:Q80TD3

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